Subtype
Malignant Anorectal Neoplasm
CI-CAN-00005864Explore in graph →
452 active trials1 approved drugs6 evidence items
- NCIt
- C215225
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Subtype
CI-CAN-00005864Explore in graph →
Clinical trials
1,783 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (174)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT07351708 | Development and Validation of a Post-operative Risk Of Local Recurrence Model Integrating Serology and Evalution (PROMISE) in Local Advanced Rectal Cancer Receiving Neoadjuvant Therapy: a Multicenter Study(PROMISE model) | completed | — | 2,315 | Cai ZerongOTHER | 0 | Jan 20, 2026 | clinicaltrials |
| NCT07346729 | Exploring the Predictive Effect of Intestinal and Oral Microbiota on the Efficacy of Neoadjuvant Radiotherapy and Chemotherapy for Locally Advanced Rectal Cancer Based on Machine Learning | completed | — | 60 | Nanfang Hospital, Southern Medical University |
| 1 |
| Jan 16, 2026 |
| clinicaltrials |
| NCT05876026 | MRI T1 Relaxation Time in Rectal Cancer | completed | — | 44 | Vejle HospitalOTHER | 1 | Jan 7, 2026 | clinicaltrials |
| NCT05215379 | Neoadjuvant Chemoradiation Therapy Combined With Immunotherapy for MSS Ultra-low Rectal Cancer | completed | Phase 2 / Phase 3 | 201 | Changhai HospitalOTHER | 1 | Jan 2, 2026 | clinicaltrials |
| NCT04369053 | Prevention of Colorectal Cancer Through Multiomics Blood Testing(PREEMPT CRC) | completed | — | 48,995 | Freenome Holdings Inc.INDUSTRY | 2 | Dec 26, 2025 | clinicaltrials |
| NCT02314182 | GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis(GRECCAR8) | completed | Phase 3 | 5 | Hospices Civils de LyonOTHER | 1 | Dec 19, 2025 | clinicaltrials |
| NCT02965521 | Survivor Choices for Eating and Drinking - Colorectal Cancer(SUCCEED) | completed | N/A | 50 | University of California, San FranciscoOTHER | 1 | Dec 17, 2025 | clinicaltrials |
| NCT04157985 | Evaluating Length of Treatment With PD-1/PD-L1 Inhibitor in Advanced Solid Tumors | completed | Phase 3 | 161 | Dan ZandbergOTHER | 1 | Dec 11, 2025 | clinicaltrials |
| NCT04417699 | SHOrt Course Radiation and TASOX (TAS102 Plus Oxaliplatin) Chemotherapy in Operable Rectal Cancer(SHORT) | completed | Phase 2 | 13 | Providence Health & ServicesOTHER | 1 | Dec 10, 2025 | clinicaltrials |
| NCT02921256 | Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer | completed | Phase 2 | 363 | National Cancer Institute (NCI)NIH | 2 | Dec 4, 2025 | clinicaltrials |
| NCT03628248 | Effect of Endovascular Inferior Mesenteric Artery Embolization on Colonic Perfusion Prior to Rectal Surgery for Rectal Tumor or Sigmoid Colon Surgery(AMIREMBOL) | completed | N/A | 10 | Centre Hospitalier Universitaire de NīmesOTHER | 1 | Dec 4, 2025 | clinicaltrials |
| NCT06493240 | Neoadjuvant Long-course Chemoradiotherapy Followed by Immunotherapy for Locally Advanced Mid-low Rectal Cancer(NLCCRIT-LARC) | completed | Phase 2 | 30 | Peking University People's HospitalOTHER | 1 | Nov 25, 2025 | clinicaltrials |
| NCT06331403 | Open Pilot Trial of a Mind-Body Sexual Well-Being Intervention for Female GI Cancer Survivors | completed | N/A | 6 | Massachusetts General HospitalOTHER | 1 | Nov 24, 2025 | clinicaltrials |
| NCT01347697 | Collagen Implant (Biological Mesh) Versus GM Flap for Reconstruction of Pelvic Floor After ELAPE in Rectal Cancer(NEAPE) | completed | N/A | 91 | Umeå UniversityOTHER | 2 | Oct 3, 2025 | clinicaltrials |
| NCT01843218 | Erectile Rating During the Treatment of Rectal Cancers Localized(METEORR) | completed | N/A | 12 | Institut BergoniéOTHER | 1 | Sep 23, 2025 | clinicaltrials |
| NCT01999634 | Monitoring by Microdialysis of Postoperative Complications After Proctectomy(MTM-COLON-II) | completed | Phase 3 | 21 | Centre Hospitalier Universitaire, AmiensOTHER | 1 | Sep 22, 2025 | clinicaltrials |
| NCT05674097 | Blood Flow Path Reconstruction in Rectal Cancer | completed | — | 89 | Shandong First Medical UniversityOTHER | 1 | Sep 22, 2025 | clinicaltrials |
| NCT01552226 | Compare Preperitoneal Analgesia to Epidural Analgesia for Pain Control After Colon and Rectal Surgery | completed | N/A | 98 | Trinity Health MichiganOTHER | 1 | Sep 15, 2025 | clinicaltrials |
| NCT04534075 | Dietary Fiber During Radiotherapy - a Placebo-controlled Randomized Trial(FIDURA) | completed | Phase 3 | 354 | Sahlgrenska University HospitalOTHER | 1 | Sep 8, 2025 | clinicaltrials |
| NCT02605265 | Trial of Capecitabine With or Without Irinotecan Driven by UGT1A1(CinClare) | completed | Phase 3 | 356 | Fudan UniversityOTHER | 1 | Aug 28, 2025 | clinicaltrials |
| NCT06582849 | Enhanced Assistance During Radiotherapy for Unmet Essential Needs(EARN) | completed | N/A | 33 | Washington University School of MedicineOTHER | 1 | Aug 26, 2025 | clinicaltrials |
| NCT06314750 | Deep Learning Based MRI Radiomics in Predicting the Clinical Risk of Locally Advanced Rectal Cancer | completed | — | 186 | Sixth Affiliated Hospital, Sun Yat-sen UniversityOTHER | 0 | Aug 14, 2025 | clinicaltrials |
| NCT06505863 | Quality of Life After Transanal Total Mesorectal Excision Compared to Traditional Total Mesorectal Excision | completed | — | 249 | Cantonal Hospital of St. GallenOTHER | 1 | Jul 14, 2025 | clinicaltrials |
| NCT02785263 | Shared Decision Making With Anal Cancer Patients on Radiation Dose(PC-Anal-01) | completed | N/A | 27 | Vejle HospitalOTHER | 1 | Jul 8, 2025 | clinicaltrials |
| NCT07049627 | AI-Based Prediction of Pathological Response in Rectal Cancer Patients Receiving Total Neoadjuvant Therapy(CINR-AI) | completed | — | 93 | Ankara Etlik City HospitalOTHER_GOV | 1 | Jul 8, 2025 | clinicaltrials |
| NCT03519295 | A Study of mDCF in Combination or Not With Atezolizumab in Advanced Squamous Cell Anal Carcinoma(SCARCE) | completed | Phase 2 | 97 | GERCOR - Multidisciplinary Oncology Cooperative GroupOTHER | 1 | Jun 27, 2025 | clinicaltrials |
| NCT02368886 | Lower or Standard Dose Regorafenib in Treating Patients With Refractory Metastatic Colorectal Cancer | completed | Phase 2 | 123 | Academic and Community Cancer Research UnitedOTHER | 1 | Jun 18, 2025 | clinicaltrials |
| NCT07021378 | Tolerance to Immunomodulatory Nutritional Therapy in Oncology Patients Undergoing Chemotherapy and Radiotherapy(NESTLE) | completed | N/A | 16 | D'Or Institute for Research and EducationOTHER | 1 | Jun 15, 2025 | clinicaltrials |
| NCT01804790 | Efficacy of Neoadjuvant Folfirinox Regimen in Patients With Resectable Locally Advanced Rectal Cancer(Néofirinox) | completed | Phase 3 | 461 | UNICANCEROTHER | 1 | Jun 12, 2025 | clinicaltrials |
| NCT04554836 | MoLiMoR - A Study With FOLFIRI-based First-line Therapy With or Without Intermittent Cetuximab | completed | Phase 2 | 6 | TheraOpOTHER | 1 | Jun 8, 2025 | clinicaltrials |
| NCT01493206 | A Prospective Single Arm Study of Intraoperative Radiotherapy for Locally Advanced or Recurrent Rectal Cancer | completed | Phase 2 | 32 | Peter MacCallum Cancer Centre, AustraliaOTHER | 1 | May 31, 2025 | clinicaltrials |
| NCT00324415 | Combined Modality Therapy for Patients With With HIV and Stage I, Stage II, or Stage III Anal Cancer | completed | Phase 2 | 45 | AIDS Malignancy ConsortiumNETWORK | 1 | May 30, 2025 | clinicaltrials |
| NCT05667181 | The Application Value of da Vinci Linear Cutting Stapler SureForm in Robotic Anus Preserving Surgery for Rectal Cancer | completed | N/A | 276 | Nanchang UniversityOTHER | 1 | May 28, 2025 | clinicaltrials |
| NCT02632448 | A Study of LY2880070 in Participants With Advanced or Metastatic Cancer | completed | Phase 1 / Phase 2 | 229 | Esperas Pharma Inc.OTHER | 4 | May 2, 2025 | clinicaltrials |
| NCT04328740 | Phase 1 Study of Oral TP-1454 | completed | Phase 1 | 31 | Sumitomo Pharma America, Inc.INDUSTRY | 1 | May 1, 2025 | clinicaltrials |
| NCT06950996 | A Clinical Evaluation of AI Solutions Developed in the CHAIMELEON Project for Cancer: Prostate, Lung, Breast, Colon and Rectum | completed | — | 300 | Instituto de Investigacion Sanitaria La FeOTHER | 1 | Apr 30, 2025 | clinicaltrials |
| NCT04441580 | Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting(GENIAL-CO) | completed | N/A | 900 | Fondazione Poliambulanza Istituto OspedalieroOTHER | 1 | Apr 10, 2025 | clinicaltrials |
| NCT03894618 | SL-279252 (PD1-Fc-OX40L) in Subjects With Advanced Solid Tumors or Lymphomas | completed | Phase 1 | 49 | Shattuck Labs, Inc.INDUSTRY | 4 | Apr 2, 2025 | clinicaltrials |
| NCT05390398 | Study on Fatigue in Colorectal Cancer Survivors, a Lifestyle Intervention(SoFiT) | completed | N/A | 161 | Wageningen UniversityOTHER | 1 | Mar 28, 2025 | clinicaltrials |
| NCT06900686 | Clinical Application of PD-1 Inhibitor in Colorectal Cancer for Improving Survival | completed | — | 458 | Yanhong DengOTHER | 0 | Mar 28, 2025 | clinicaltrials |
| NCT06898359 | Role of Gut Microbiota in Neoadjuvant Radioimmunotherapy for MSS, Locally Advanced Rectal Cancer | completed | — | 29 | Yanhong DengOTHER | 1 | Mar 27, 2025 | clinicaltrials |
| NCT00200200 | Hepatic Arterial Infusion With Floxuridine and Dexamethasone Combination With Chemotherapy With/Without Bevacizumab for Hepatic Metastases From Colorectal Cancer | completed | Phase 2 | 73 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Mar 19, 2025 | clinicaltrials |
| NCT01226979 | Study of High-Dose-Rate Endorectal Brachytherapy (HDRBT) in the Treatment of Locally Advanced Low Rectal Cancer(HDRBT) | completed | N/A | 16 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Feb 28, 2025 | clinicaltrials |
| NCT01643070 | Preoperative CRT With or Without Induction Chemotherapy for Rectal Cancer With Liver Metastases | completed | Phase 2 | 38 | Asan Medical CenterOTHER | 1 | Feb 25, 2025 | clinicaltrials |
| NCT04380337 | Organ Preservation Program Using Short-Course Radiation & FOLFOXIRI in Rectal Cancer | completed | Phase 2 | 38 | Stanford UniversityOTHER | 1 | Feb 25, 2025 | clinicaltrials |
| NCT04947020 | DataBase for Analysis of Rectal Cancer Oncological Results(BARO) | completed | — | 2,443 | Jagiellonian UniversityOTHER | 1 | Feb 25, 2025 | clinicaltrials |
| NCT06839508 | Comprehensive Management of Rectal Cancer(CMRC) | completed | — | 8 | Centre Hospitalier de Saint-DenisOTHER | 1 | Feb 24, 2025 | clinicaltrials |
| NCT04357873 | Efficacy of Immunotherapy Plus a Drug in Patients With Progressive Advanced Mucosal Cancer of Different Locations(PEVOsq) | completed | Phase 2 | 112 | UNICANCEROTHER | 1 | Feb 19, 2025 | clinicaltrials |
| NCT05445245 | The Longitudinal Study of Low Anterior Resection Syndrome in Patients with Newly Diagnosed Rectal Cancer. | completed | — | 125 | Chang Gung Memorial HospitalOTHER | 1 | Feb 14, 2025 | clinicaltrials |
Data updated 22 days agoSource updated Jan 20, 2026source: clinicaltrials