Clinical trial · Observational
Quality of Life After Transanal Total Mesorectal Excision Compared to Traditional Total Mesorectal Excision
Does Transanal Total Mesorectal Excision (taTME) Result in Better Quality of Life and Functional Outcomes Than Traditional Total Mesorectal Excision? A Retrospective Propensity Score-adjusted Cohort Study
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The improvement in prognosis of rectal cancer through modern therapy modalities rises questions regarding quality of life (QoL) and functional outcomes. Evidence for long-term QoL and functional outcomes of transanal total mesorectal excision (taTME) is not provided in current literature. This study will compare short-term and long-term QoL and functional outcomes after taTME compared to traditional abdominal TME (laparoscopic, robotic, and open approach)
Conditions
Conditions (4)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Functional Outcome | — | UNRESOLVED | — |
| Quality of Life | — | UNRESOLVED | — |
| Rectal Cancer | Malignant Rectal Neoplasm | CURATED_EXACT | 0.92 |
| Surgery | — | UNRESOLVED | — |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Abdominal total mesorectal excision | Procedure | — | UNRESOLVED |
| Transanal total mesorectal excision | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- taTME
- description
- Patients who underwent transanal total mesorectal excision with anastomosis for primary rectal cancer UICC stage I to III
- interventionNames
- Procedure: Transanal total mesorectal excision
- label
- abTME
- description
- Patients who underwent laparoscopic, robotic, or open total mesorectal excision with anastomosis for primary rectal cancer UICC stage I to III
- interventionNames
- Procedure: Abdominal total mesorectal excision
Primary outcomes (1)
- measure
- Quality of life (QoL)
- timeFrame
- 5 years after initial operation
- description
- Assessed by the European Organization for Research and Treatment of Cancer core questionnaire (EORTC QLQ-C30): * Overall QoL * QLQ-total
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * elective total mesorectal excision followed by reconstruction with anastomosis for primary rectal cancer Exclusion Criteria: * diagnoses other than rectal cancer * recurrent rectal cancer * partial mesorectal excision * discontinuity resection (no anastomosis) * incomplete TNM staging information * metastatic cancer * 30-day mortality * lack of quality of life data * patient decline * age under 18 years
References
Publications (2)
- BACKGROUNDHeald RJ. The 'Holy Plane' of rectal surgery. J R Soc Med. 1988 Sep;81(9):503-8. doi: 10.1177/014107688808100904. No abstract available. PMID 3184105
- DERIVEDAmmann Y, Klein M, Marti L, Warschkow R, Strose L, Sparn M, Jager T, Bischofberger S, Brunner W. Does transanal total mesorectal excision (taTME) result in better quality of life and functional outcomes than traditional TME does? A retrospective propensity score-adjusted cohort study. Langenbecks Arch Surg. 2025 Apr 30;410(1):149. doi: 10.1007/s00423-025-03724-6. PMID 40304801