Lung Non-Squamous Non-Small Cell Carcinoma

Lung Non-Squamous Non-Small Cell Carcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

20 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

APOLLO1: Proteogenomic characterization of lung adenocarcinoma APOLLO-LUADAPOLLO

87 cases with simple somatic mutation data · 87 cases total · Data Release 46.0 · mapped to Lung Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

CDDP Integrative Analysis of Lung Adenocarcinoma (Phase 2) CDDP_EAGLE-1CDDP_EAGLE

50 cases with simple somatic mutation data · 50 cases total · Data Release 46.0 · mapped to Lung Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	PRPF3	Ssm	35	50	70%	gdc
2	SPTA1	Ssm	35	50	70%	gdc
3	ECM1	Ssm	34	50	68%	gdc
4	SETDB1	Ssm	34	50	68%	gdc
5	CA14	Ssm	34	50	68%	gdc
6	PRUNE1	Ssm	34	50	68%	gdc
7	ADAMTSL4	Ssm	34	50	68%	gdc
8	PIP5K1A	Ssm	34	50	68%	gdc
9	MRPS21	Ssm	34	50	68%	gdc
10	ANP32E	Ssm	34	50	68%	gdc
11	RPRD2	Ssm	34	50	68%	gdc
12	GBA	Ssm	34	50	68%	gdc
13	TARS2	Ssm	34	50	68%	gdc
14	C1orf54	Ssm	34	50	68%	gdc
15	SYT11	Ssm	34	50	68%	gdc
16	CTXND2	Ssm	34	50	68%	gdc
17	MTX1	Ssm	34	50	68%	gdc
18	CIART	Ssm	34	50	68%	gdc
19	TTN	Ssm	34	50	68%	gdc
20	APH1A	Ssm	34	50	68%	gdc
21	CERS2	Ssm	34	50	68%	gdc
22	MSTO1	Ssm	33	50	66%	gdc
23	ANXA9	Ssm	33	50	66%	gdc
24	SCAMP3	Ssm	33	50	66%	gdc
25	CLK2	Ssm	33	50	66%	gdc
26	MLLT11	Ssm	33	50	66%	gdc
27	POGZ	Ssm	33	50	66%	gdc
28	GON4L	Ssm	33	50	66%	gdc
29	SEMA6C	Ssm	33	50	66%	gdc
30	RFX5	Ssm	33	50	66%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Lung Adenocarcinoma TCGA-LUADTCGA

573 cases with simple somatic mutation data · 585 cases total · Data Release 46.0 · mapped to Lung Adenocarcinoma ONTOLOGY_EXACT

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	RYR2	Ssm	413	573	72.1%	gdc
2	FLG	Ssm	406	573	70.9%	gdc
3	USH2A	Ssm	402	573	70.2%	gdc
4	SPTA1	Ssm	400	573	69.8%	gdc
5	TP53	Ssm	393	573	68.6%	gdc
6	FLG2	Ssm	388	573	67.7%	gdc
8	HRNR	Ssm	383	573	66.8%	gdc
7	CSMD3	Ssm	383	573	66.8%	gdc
9	TNR	Ssm	382	573	66.7%	gdc
11	ASH1L	Ssm	382	573	66.7%	gdc
10	TNN	Ssm	382	573	66.7%	gdc
12	HMCN1	Ssm	379	573	66.1%	gdc
13	MUC16	Ssm	376	573	65.6%	gdc
15	TCHH	Ssm	374	573	65.3%	gdc
14	CACNA1E	Ssm	374	573	65.3%	gdc
16	PAPPA2	Ssm	374	573	65.3%	gdc
17	ASTN1	Ssm	373	573	65.1%	gdc
18	KCNN3	Ssm	372	573	64.9%	gdc
20	ASPM	Ssm	371	573	64.7%	gdc
19	NUP210L	Ssm	371	573	64.7%	gdc
23	FCRL5	Ssm	370	573	64.6%	gdc
22	ADAR	Ssm	370	573	64.6%	gdc
21	ATP8B2	Ssm	370	573	64.6%	gdc
25	AQP10	Ssm	369	573	64.4%	gdc
26	PKLR	Ssm	369	573	64.4%	gdc
24	NPR1	Ssm	369	573	64.4%	gdc
29	SETDB1	Ssm	368	573	64.2%	gdc
27	CLK2	Ssm	368	573	64.2%	gdc
30	SEMA6C	Ssm	368	573	64.2%	gdc
28	PEAR1	Ssm	368	573	64.2%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Lung Adenocarcinoma (Broad, Cell 2012) luad_broadBroad

183 cases with simple somatic mutation data · 183 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	95	183	51.9%	cbioportal
2	TTN	Ssm	83	183	45.4%	cbioportal
3	MUC16	Ssm	71	183	38.8%	cbioportal
4	USH2A	Ssm	64	183	35%	cbioportal
5	CSMD3	Ssm	62	183	33.9%	cbioportal
6	RYR2	Ssm	62	183	33.9%	cbioportal
7	LRP1B	Ssm	59	183	32.2%	cbioportal
8	SPTA1	Ssm	56	183	30.6%	cbioportal
9	KRAS	Ssm	49	183	26.8%	cbioportal
10	XIRP2	Ssm	49	183	26.8%	cbioportal
11	ZFHX4	Ssm	49	183	26.8%	cbioportal
12	FAT3	Ssm	48	183	26.2%	cbioportal
13	FLG	Ssm	48	183	26.2%	cbioportal
14	PCLO	Ssm	43	183	23.5%	cbioportal
15	PCDH15	Ssm	40	183	21.9%	cbioportal
16	OBSCN	Ssm	37	183	20.2%	cbioportal
19	CSMD1	Ssm	35	183	19.1%	cbioportal
17	ABCA13	Ssm	35	183	19.1%	cbioportal
18	APOB	Ssm	35	183	19.1%	cbioportal
20	MUC17	Ssm	35	183	19.1%	cbioportal
21	PAPPA2	Ssm	35	183	19.1%	cbioportal
22	RYR3	Ssm	35	183	19.1%	cbioportal
23	SI	Ssm	35	183	19.1%	cbioportal
24	NRXN1	Ssm	34	183	18.6%	cbioportal
25	COL11A1	Ssm	32	183	17.5%	cbioportal
26	EGFR	Ssm	32	183	17.5%	cbioportal
27	RELN	Ssm	32	183	17.5%	cbioportal
28	RP1L1	Ssm	32	183	17.5%	cbioportal
29	ADGRL3	Ssm	31	183	16.9%	cbioportal
30	DNAH9	Ssm	31	183	16.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (CAS, Cell 2020) luad_cas_2020CAS

103 cases with simple somatic mutation data · 103 cases total · 2026-01-19 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	53	103	51.5%	cbioportal
2	EGFR	Ssm	51	103	49.5%	cbioportal
3	TTN	Ssm	23	103	22.3%	cbioportal
4	RYR2	Ssm	15	103	14.6%	cbioportal
5	MUC16	Ssm	13	103	12.6%	cbioportal
6	AHNAK2	Ssm	12	103	11.7%	cbioportal
7	MUC17	Ssm	12	103	11.7%	cbioportal
8	OBSCN	Ssm	12	103	11.7%	cbioportal
9	ZNF536	Ssm	11	103	10.7%	cbioportal
10	APOB	Ssm	10	103	9.7%	cbioportal
11	CSMD3	Ssm	10	103	9.7%	cbioportal
12	FLG	Ssm	10	103	9.7%	cbioportal
13	HMCN1	Ssm	10	103	9.7%	cbioportal
14	COL11A1	Ssm	9	103	8.7%	cbioportal
15	DMD	Ssm	9	103	8.7%	cbioportal
16	FAT3	Ssm	9	103	8.7%	cbioportal
17	MUC12	Ssm	9	103	8.7%	cbioportal
18	PLEC	Ssm	9	103	8.7%	cbioportal
19	RYR1	Ssm	9	103	8.7%	cbioportal
20	SPEG	Ssm	9	103	8.7%	cbioportal
21	USH2A	Ssm	9	103	8.7%	cbioportal
22	BRINP3	Ssm	8	103	7.8%	cbioportal
23	EYS	Ssm	8	103	7.8%	cbioportal
24	ICE1	Ssm	8	103	7.8%	cbioportal
25	MUC5B	Ssm	8	103	7.8%	cbioportal
26	PAPPA2	Ssm	8	103	7.8%	cbioportal
27	PCDH15	Ssm	8	103	7.8%	cbioportal
28	RELN	Ssm	8	103	7.8%	cbioportal
29	RYR3	Ssm	8	103	7.8%	cbioportal
30	TENM4	Ssm	8	103	7.8%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Lung Adenocarcinoma (CPTAC, Cell 2020) luad_cptac_2020CPTAC

110 cases with simple somatic mutation data · 110 cases total · 2026-01-16 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	59	110	53.6%	cbioportal
2	EGFR	Ssm	38	110	34.5%	cbioportal
3	MUC16	Ssm	37	110	33.6%	cbioportal
4	RYR2	Ssm	35	110	31.8%	cbioportal
5	TTN	Ssm	35	110	31.8%	cbioportal
6	LRP1B	Ssm	34	110	30.9%	cbioportal
8	KRAS	Ssm	33	110	30%	cbioportal
7	CSMD3	Ssm	33	110	30%	cbioportal
9	USH2A	Ssm	28	110	25.5%	cbioportal
10	ZFHX4	Ssm	26	110	23.6%	cbioportal
11	FAT3	Ssm	23	110	20.9%	cbioportal
12	COL11A1	Ssm	22	110	20%	cbioportal
13	FAM135B	Ssm	21	110	19.1%	cbioportal
14	SPTA1	Ssm	21	110	19.1%	cbioportal
15	CSMD1	Ssm	20	110	18.2%	cbioportal
16	PCLO	Ssm	20	110	18.2%	cbioportal
17	STK11	Ssm	20	110	18.2%	cbioportal
18	APOB	Ssm	19	110	17.3%	cbioportal
19	EYS	Ssm	19	110	17.3%	cbioportal
20	MUC17	Ssm	19	110	17.3%	cbioportal
21	NRXN1	Ssm	19	110	17.3%	cbioportal
22	PCDH15	Ssm	19	110	17.3%	cbioportal
23	CNTNAP2	Ssm	18	110	16.4%	cbioportal
24	FLG	Ssm	18	110	16.4%	cbioportal
25	XIRP2	Ssm	18	110	16.4%	cbioportal
26	ADAMTS12	Ssm	17	110	15.5%	cbioportal
27	ANK2	Ssm	17	110	15.5%	cbioportal
28	FBN2	Ssm	17	110	15.5%	cbioportal
29	LRTM3	Ssm	17	110	15.5%	cbioportal
30	NAV3	Ssm	17	110	15.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Lung Adenocarcinoma (CPTAC GDC, 2025) luad_cptac_gdcCPTAC GDC

236 cases with simple somatic mutation data · 241 cases total · 2026-01-14 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	119	236	50.4%	cbioportal
2	RYR2	Ssm	80	236	33.9%	cbioportal
3	CSMD3	Ssm	76	236	32.2%	cbioportal
4	MUC16	Ssm	75	236	31.8%	cbioportal
5	EGFR	Ssm	70	236	29.7%	cbioportal
6	USH2A	Ssm	70	236	29.7%	cbioportal
7	KRAS	Ssm	69	236	29.2%	cbioportal
8	TTN	Ssm	68	236	28.8%	cbioportal
9	ZFHX4	Ssm	57	236	24.2%	cbioportal
10	LRP1B	Ssm	53	236	22.5%	cbioportal
11	XIRP2	Ssm	53	236	22.5%	cbioportal
12	CSMD1	Ssm	51	236	21.6%	cbioportal
13	FSIP2	Ssm	51	236	21.6%	cbioportal
14	LRTM3	Ssm	47	236	19.9%	cbioportal
15	SPTA1	Ssm	47	236	19.9%	cbioportal
16	FAT3	Ssm	45	236	19.1%	cbioportal
17	EYS	Ssm	44	236	18.6%	cbioportal
18	MUC17	Ssm	44	236	18.6%	cbioportal
19	PCLO	Ssm	42	236	17.8%	cbioportal
20	APOB	Ssm	41	236	17.4%	cbioportal
21	COL11A1	Ssm	41	236	17.4%	cbioportal
22	FLG	Ssm	41	236	17.4%	cbioportal
23	SYNE1	Ssm	40	236	16.9%	cbioportal
24	ZNF536	Ssm	40	236	16.9%	cbioportal
25	PCDH15	Ssm	38	236	16.1%	cbioportal
26	FAT4	Ssm	37	236	15.7%	cbioportal
27	NAV3	Ssm	37	236	15.7%	cbioportal
28	STK11	Ssm	37	236	15.7%	cbioportal
29	ANK2	Ssm	36	236	15.3%	cbioportal
30	RYR3	Ssm	36	236	15.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Lung Adenocarcinoma Met Organotropism (MSK, Cancer Cell 2023) luad_mskcc_2023_met_organotropismMSK

2,653 cases with simple somatic mutation data · 2,653 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	1,429	2,653	53.9%	cbioportal
59	TTN	Ssm	90	231	39%	cbioportal
65	RYR2	Ssm	85	231	36.8%	cbioportal
2	EGFR	Ssm	866	2,653	32.6%	cbioportal
82	MUC16	Ssm	72	231	31.2%	cbioportal
3	KRAS	Ssm	787	2,653	29.7%	cbioportal
90	CSMD3	Ssm	65	231	28.1%	cbioportal
94	LRP1B	Ssm	64	231	27.7%	cbioportal
102	USH2A	Ssm	61	231	26.4%	cbioportal
119	CSMD1	Ssm	54	231	23.4%	cbioportal
125	FSIP2	Ssm	52	231	22.5%	cbioportal
144	EYS	Ssm	45	231	19.5%	cbioportal
153	ZNF536	Ssm	43	231	18.6%	cbioportal
152	ZFHX4	Ssm	43	231	18.6%	cbioportal
149	PCDH15	Ssm	43	231	18.6%	cbioportal
150	SPTA1	Ssm	43	231	18.6%	cbioportal
154	ABCA13	Ssm	42	231	18.2%	cbioportal
164	CACNA1E	Ssm	41	231	17.7%	cbioportal
168	XIRP2	Ssm	41	231	17.7%	cbioportal
4	STK11	Ssm	450	2,653	17%	cbioportal
183	FAT3	Ssm	38	231	16.5%	cbioportal
182	ASXL3	Ssm	38	231	16.5%	cbioportal
186	RYR1	Ssm	38	231	16.5%	cbioportal
191	MUC17	Ssm	37	231	16%	cbioportal
189	COL11A1	Ssm	37	231	16%	cbioportal
198	PAPPA2	Ssm	36	231	15.6%	cbioportal
200	ANK2	Ssm	35	231	15.2%	cbioportal
5	KEAP1	Ssm	400	2,653	15.1%	cbioportal
6	RBM10	Ssm	294	2,653	11.1%	cbioportal
7	PTPRD	Ssm	270	2,653	10.2%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (MSK, 2021) luad_mskimpact_2021MSK

186 cases with simple somatic mutation data · 186 cases total · 2026-04-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	EGFR	Ssm	183	186	98.4%	cbioportal
2	TP53	Ssm	128	186	68.8%	cbioportal
3	PIK3CA	Ssm	20	186	10.8%	cbioportal
4	RB1	Ssm	19	186	10.2%	cbioportal
5	CTNNB1	Ssm	18	186	9.7%	cbioportal
6	RBM10	Ssm	14	186	7.5%	cbioportal
7	PTEN	Ssm	13	186	7%	cbioportal
8	ARID1A	Ssm	10	186	5.4%	cbioportal
10	PTPRD	Ssm	9	186	4.8%	cbioportal
9	ATR	Ssm	9	186	4.8%	cbioportal
13	ZFHX3	Ssm	8	185	4.3%	cbioportal
11	APC	Ssm	8	186	4.3%	cbioportal
12	KMT2C	Ssm	8	186	4.3%	cbioportal
14	SMARCA4	Ssm	7	186	3.8%	cbioportal
16	FAT1	Ssm	6	186	3.2%	cbioportal
18	TSC2	Ssm	6	186	3.2%	cbioportal
17	NOTCH4	Ssm	6	186	3.2%	cbioportal
15	ASXL1	Ssm	6	186	3.2%	cbioportal
27	PLCG2	Ssm	5	185	2.7%	cbioportal
23	MGA	Ssm	5	185	2.7%	cbioportal
24	MTOR	Ssm	5	186	2.7%	cbioportal
22	MED12	Ssm	5	186	2.7%	cbioportal
25	NBN	Ssm	5	186	2.7%	cbioportal
26	NOTCH2	Ssm	5	186	2.7%	cbioportal
19	EPHA5	Ssm	5	186	2.7%	cbioportal
21	KEAP1	Ssm	5	186	2.7%	cbioportal
20	H1-2	Ssm	5	186	2.7%	cbioportal
28	PTPRT	Ssm	5	186	2.7%	cbioportal
29	TET1	Ssm	5	186	2.7%	cbioportal
35	CSF3R	Ssm	4	185	2.2%	cbioportal

Data updated 22 days agoSource updated 2026-04-07

Lung Adenocarcinoma (MSK, J Thorac Oncol 2020) luad_mskcc_2020MSK

604 cases with simple somatic mutation data · 604 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	KRAS	Ssm	230	604	38.1%	cbioportal
2	TP53	Ssm	219	604	36.3%	cbioportal
3	EGFR	Ssm	182	604	30.1%	cbioportal
4	RBM10	Ssm	97	604	16.1%	cbioportal
5	STK11	Ssm	90	604	14.9%	cbioportal
6	KEAP1	Ssm	68	604	11.3%	cbioportal
7	NF1	Ssm	48	604	7.9%	cbioportal
8	FAT1	Ssm	47	604	7.8%	cbioportal
10	PTPRT	Ssm	47	604	7.8%	cbioportal
9	PTPRD	Ssm	47	604	7.8%	cbioportal
11	ATM	Ssm	44	604	7.3%	cbioportal
12	SETD2	Ssm	43	604	7.1%	cbioportal
13	BRAF	Ssm	41	604	6.8%	cbioportal
14	MED12	Ssm	39	604	6.5%	cbioportal
15	EPHA3	Ssm	38	604	6.3%	cbioportal
16	PIK3CA	Ssm	35	604	5.8%	cbioportal
17	MET	Ssm	34	604	5.6%	cbioportal
18	NTRK3	Ssm	34	604	5.6%	cbioportal
19	MGA	Ssm	33	596	5.5%	cbioportal
20	SMARCA4	Ssm	33	604	5.5%	cbioportal
22	ATRX	Ssm	30	604	5%	cbioportal
23	EPHA5	Ssm	30	604	5%	cbioportal
21	ARID2	Ssm	30	604	5%	cbioportal
24	ERBB4	Ssm	29	604	4.8%	cbioportal
25	KMT2D	Ssm	28	604	4.6%	cbioportal
29	TERT	Ssm	27	604	4.5%	cbioportal
27	ERBB2	Ssm	27	604	4.5%	cbioportal
28	GRIN2A	Ssm	27	604	4.5%	cbioportal
26	CDKN2A	Ssm	27	604	4.5%	cbioportal
31	MTOR	Ssm	26	604	4.3%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (MSK, NPJ Precision Oncology 2021) luad_msk_npjpo_2021MSK

426 cases with simple somatic mutation data · 426 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	155	426	36.4%	cbioportal
2	KRAS	Ssm	147	426	34.5%	cbioportal
3	EGFR	Ssm	139	426	32.6%	cbioportal
4	RBM10	Ssm	81	426	19%	cbioportal
5	STK11	Ssm	66	426	15.5%	cbioportal
6	KEAP1	Ssm	46	426	10.8%	cbioportal
7	FAT1	Ssm	36	426	8.5%	cbioportal
8	NF1	Ssm	35	426	8.2%	cbioportal
9	PTPRD	Ssm	34	426	8%	cbioportal
10	SETD2	Ssm	34	426	8%	cbioportal
11	PTPRT	Ssm	32	426	7.5%	cbioportal
12	ATM	Ssm	30	426	7%	cbioportal
14	SMARCA4	Ssm	29	426	6.8%	cbioportal
13	BRAF	Ssm	29	426	6.8%	cbioportal
16	MED12	Ssm	28	426	6.6%	cbioportal
15	KMT2D	Ssm	28	426	6.6%	cbioportal
21	MGA	Ssm	24	418	5.7%	cbioportal
17	EPHA3	Ssm	24	426	5.6%	cbioportal
20	MET	Ssm	24	426	5.6%	cbioportal
22	NTRK3	Ssm	24	426	5.6%	cbioportal
19	KMT2C	Ssm	24	426	5.6%	cbioportal
18	GRIN2A	Ssm	24	426	5.6%	cbioportal
23	ARID2	Ssm	23	426	5.4%	cbioportal
26	PIK3C2G	Ssm	22	426	5.2%	cbioportal
24	EPHA5	Ssm	22	426	5.2%	cbioportal
25	ERBB4	Ssm	22	426	5.2%	cbioportal
27	PIK3CA	Ssm	22	426	5.2%	cbioportal
29	NOTCH4	Ssm	21	426	4.9%	cbioportal
28	FLT1	Ssm	21	426	4.9%	cbioportal
30	TERT	Ssm	20	426	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (MSK, Science 2015) luad_mskcc_2015MSK

35 cases with simple somatic mutation data · 35 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	MUC4	Ssm	19	35	54.3%	cbioportal
2	TP53	Ssm	16	35	45.7%	cbioportal
3	MUC16	Ssm	13	35	37.1%	cbioportal
4	CSMD3	Ssm	11	35	31.4%	cbioportal
6	TTN	Ssm	11	35	31.4%	cbioportal
5	LRP1B	Ssm	11	35	31.4%	cbioportal
10	ZFHX4	Ssm	10	35	28.6%	cbioportal
9	RYR2	Ssm	10	35	28.6%	cbioportal
8	OBSCN	Ssm	10	35	28.6%	cbioportal
7	HRNR	Ssm	10	35	28.6%	cbioportal
13	TNRC18	Ssm	9	35	25.7%	cbioportal
12	FLNC	Ssm	9	35	25.7%	cbioportal
11	FLG	Ssm	9	35	25.7%	cbioportal
15	KRAS	Ssm	8	35	22.9%	cbioportal
14	CROCC	Ssm	8	35	22.9%	cbioportal
20	PCDH15	Ssm	7	35	20%	cbioportal
18	CSMD1	Ssm	7	35	20%	cbioportal
17	CRB2	Ssm	7	35	20%	cbioportal
16	CACNA1A	Ssm	7	35	20%	cbioportal
19	MUC5B	Ssm	7	35	20%	cbioportal
21	ANK2	Ssm	6	35	17.1%	cbioportal
29	MUC17	Ssm	6	35	17.1%	cbioportal
28	MROH2B	Ssm	6	35	17.1%	cbioportal
27	JAG2	Ssm	6	35	17.1%	cbioportal
26	FBN2	Ssm	6	35	17.1%	cbioportal
25	DNAH11	Ssm	6	35	17.1%	cbioportal
24	CSMD2	Ssm	6	35	17.1%	cbioportal
23	CDH10	Ssm	6	35	17.1%	cbioportal
22	APOB	Ssm	6	35	17.1%	cbioportal
30	NPHP4	Ssm	6	35	17.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (OncoSG, Nat Genet 2020) luad_oncosg_2020OncoSG

302 cases with simple somatic mutation data · 305 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	EGFR	Ssm	143	302	47.4%	cbioportal
2	TP53	Ssm	109	302	36.1%	cbioportal
3	TTN	Ssm	68	302	22.5%	cbioportal
4	RYR2	Ssm	50	302	16.6%	cbioportal
5	USH2A	Ssm	50	302	16.6%	cbioportal
6	MUC16	Ssm	46	302	15.2%	cbioportal
7	CSMD3	Ssm	43	302	14.2%	cbioportal
8	ZFHX4	Ssm	39	302	12.9%	cbioportal
9	FLG	Ssm	37	302	12.3%	cbioportal
10	LRP1B	Ssm	35	302	11.6%	cbioportal
11	KRAS	Ssm	33	302	10.9%	cbioportal
12	PCLO	Ssm	30	302	9.9%	cbioportal
13	SPTA1	Ssm	30	302	9.9%	cbioportal
14	XIRP2	Ssm	30	302	9.9%	cbioportal
15	ANK2	Ssm	29	302	9.6%	cbioportal
16	SI	Ssm	27	302	8.9%	cbioportal
17	CTNND2	Ssm	26	302	8.6%	cbioportal
18	FAT3	Ssm	26	302	8.6%	cbioportal
19	MUC17	Ssm	26	302	8.6%	cbioportal
20	AHNAK2	Ssm	24	302	7.9%	cbioportal
21	COL11A1	Ssm	24	302	7.9%	cbioportal
22	CSMD1	Ssm	24	302	7.9%	cbioportal
23	FAT4	Ssm	24	302	7.9%	cbioportal
24	PRDM9	Ssm	24	302	7.9%	cbioportal
25	MUC4	Ssm	23	302	7.6%	cbioportal
26	NAV3	Ssm	23	302	7.6%	cbioportal
27	NEB	Ssm	23	302	7.6%	cbioportal
28	ZNF536	Ssm	23	302	7.6%	cbioportal
29	RBM10	Ssm	22	302	7.3%	cbioportal
30	ADAMTS12	Ssm	21	302	7%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (TCGA, Firehose Legacy) luad_tcgaTCGA

230 cases with simple somatic mutation data · 586 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	108	230	47%	cbioportal
2	TP53	Ssm	106	230	46.1%	cbioportal
3	MUC16	Ssm	91	230	39.6%	cbioportal
4	RYR2	Ssm	82	230	35.7%	cbioportal
5	KRAS	Ssm	75	230	32.6%	cbioportal
6	LRP1B	Ssm	68	230	29.6%	cbioportal
7	USH2A	Ssm	68	230	29.6%	cbioportal
8	ZFHX4	Ssm	63	230	27.4%	cbioportal
9	FLG	Ssm	62	230	27%	cbioportal
10	SPTA1	Ssm	58	230	25.2%	cbioportal
11	MUC17	Ssm	48	230	20.9%	cbioportal
12	XIRP2	Ssm	47	230	20.4%	cbioportal
13	PCLO	Ssm	46	230	20%	cbioportal
14	NAV3	Ssm	45	230	19.6%	cbioportal
15	CSMD1	Ssm	44	230	19.1%	cbioportal
16	FAT3	Ssm	44	230	19.1%	cbioportal
17	KMT2C	Ssm	42	230	18.3%	cbioportal
18	PCDH15	Ssm	42	230	18.3%	cbioportal
19	ZNF536	Ssm	42	230	18.3%	cbioportal
20	COL11A1	Ssm	40	230	17.4%	cbioportal
21	KEAP1	Ssm	40	230	17.4%	cbioportal
22	STK11	Ssm	40	230	17.4%	cbioportal
23	ADGRG4	Ssm	39	230	17%	cbioportal
24	PAPPA2	Ssm	39	230	17%	cbioportal
25	RP1L1	Ssm	39	230	17%	cbioportal
26	ADAMTS12	Ssm	38	230	16.5%	cbioportal
27	AHNAK2	Ssm	38	230	16.5%	cbioportal
28	APOB	Ssm	38	230	16.5%	cbioportal
29	ZNF804A	Ssm	38	230	16.5%	cbioportal
30	DNAH9	Ssm	37	230	16.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Adenocarcinoma (TCGA GDC, 2025) luad_tcga_gdcTCGA GDC

559 cases with simple somatic mutation data · 571 cases total · 2026-01-13 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	284	559	50.8%	cbioportal
2	TTN	Ssm	245	559	43.8%	cbioportal
3	MUC16	Ssm	225	559	40.3%	cbioportal
4	CSMD3	Ssm	213	559	38.1%	cbioportal
5	RYR2	Ssm	200	559	35.8%	cbioportal
6	LRP1B	Ssm	184	559	32.9%	cbioportal
7	ZFHX4	Ssm	172	559	30.8%	cbioportal
8	USH2A	Ssm	168	559	30.1%	cbioportal
9	KRAS	Ssm	149	559	26.7%	cbioportal
10	XIRP2	Ssm	134	559	24%	cbioportal
11	FLG	Ssm	129	559	23.1%	cbioportal
12	SPTA1	Ssm	124	559	22.2%	cbioportal
13	NAV3	Ssm	117	559	20.9%	cbioportal
14	COL11A1	Ssm	114	559	20.4%	cbioportal
15	ZNF536	Ssm	112	559	20%	cbioportal
16	FAT3	Ssm	107	559	19.1%	cbioportal
17	ANK2	Ssm	106	559	19%	cbioportal
18	CSMD1	Ssm	103	559	18.4%	cbioportal
19	PCLO	Ssm	103	559	18.4%	cbioportal
20	APOB	Ssm	101	559	18.1%	cbioportal
21	PCDH15	Ssm	101	559	18.1%	cbioportal
22	KEAP1	Ssm	98	559	17.5%	cbioportal
23	ADAMTS12	Ssm	97	559	17.4%	cbioportal
24	MUC17	Ssm	97	559	17.4%	cbioportal
25	TNR	Ssm	95	559	17%	cbioportal
26	DNAH9	Ssm	93	559	16.6%	cbioportal
27	PAPPA2	Ssm	90	559	16.1%	cbioportal
28	RP1L1	Ssm	90	559	16.1%	cbioportal
29	ADGRG4	Ssm	89	559	15.9%	cbioportal
30	RYR3	Ssm	89	559	15.9%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Lung Adenocarcinoma (TCGA, Nature 2014) luad_tcga_pubTCGA

230 cases with simple somatic mutation data · 230 cases total · 2026-01-19 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	108	230	47%	cbioportal
2	TP53	Ssm	107	230	46.5%	cbioportal
3	MUC16	Ssm	91	230	39.6%	cbioportal
4	RYR2	Ssm	82	230	35.7%	cbioportal
5	CSMD3	Ssm	81	230	35.2%	cbioportal
6	KRAS	Ssm	75	230	32.6%	cbioportal
7	LRP1B	Ssm	68	230	29.6%	cbioportal
8	USH2A	Ssm	68	230	29.6%	cbioportal
9	ZFHX4	Ssm	63	230	27.4%	cbioportal
10	FLG	Ssm	62	230	27%	cbioportal
11	SPTA1	Ssm	58	230	25.2%	cbioportal
12	MUC17	Ssm	48	230	20.9%	cbioportal
13	XIRP2	Ssm	47	230	20.4%	cbioportal
14	PCLO	Ssm	46	230	20%	cbioportal
15	NAV3	Ssm	45	230	19.6%	cbioportal
17	FAT3	Ssm	44	230	19.1%	cbioportal
16	CSMD1	Ssm	44	230	19.1%	cbioportal
18	KMT2C	Ssm	43	230	18.7%	cbioportal
20	ZNF536	Ssm	42	230	18.3%	cbioportal
19	PCDH15	Ssm	42	230	18.3%	cbioportal
21	COL11A1	Ssm	40	230	17.4%	cbioportal
23	STK11	Ssm	40	230	17.4%	cbioportal
22	KEAP1	Ssm	40	230	17.4%	cbioportal
26	RP1L1	Ssm	39	230	17%	cbioportal
25	PAPPA2	Ssm	39	230	17%	cbioportal
24	ADGRG4	Ssm	39	230	17%	cbioportal
29	APOB	Ssm	38	230	16.5%	cbioportal
28	AHNAK2	Ssm	38	230	16.5%	cbioportal
27	ADAMTS12	Ssm	38	230	16.5%	cbioportal
30	ZNF804A	Ssm	38	230	16.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-19

Lung Adenocarcinoma (TCGA, PanCancer Atlas) luad_tcga_pan_can_atlas_2018TCGA

566 cases with simple somatic mutation data · 566 cases total · 2026-06-04 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	295	566	52.1%	cbioportal
2	TTN	Ssm	272	566	48.1%	cbioportal
3	MUC16	Ssm	242	566	42.8%	cbioportal
4	CSMD3	Ssm	226	566	39.9%	cbioportal
5	RYR2	Ssm	217	566	38.3%	cbioportal
6	LRP1B	Ssm	201	566	35.5%	cbioportal
7	ZFHX4	Ssm	185	566	32.7%	cbioportal
8	USH2A	Ssm	177	566	31.3%	cbioportal
9	KRAS	Ssm	168	566	29.7%	cbioportal
10	XIRP2	Ssm	150	566	26.5%	cbioportal
11	SPTA1	Ssm	148	566	26.1%	cbioportal
12	FLG	Ssm	145	566	25.6%	cbioportal
13	CSMD1	Ssm	125	566	22.1%	cbioportal
14	NAV3	Ssm	123	566	21.7%	cbioportal
15	FAT3	Ssm	121	566	21.4%	cbioportal
16	COL11A1	Ssm	120	566	21.2%	cbioportal
17	PCDH15	Ssm	118	566	20.8%	cbioportal
18	ZNF536	Ssm	117	566	20.7%	cbioportal
19	ANK2	Ssm	111	566	19.6%	cbioportal
20	MUC17	Ssm	111	566	19.6%	cbioportal
21	PCLO	Ssm	109	566	19.3%	cbioportal
22	RYR3	Ssm	106	566	18.7%	cbioportal
23	APOB	Ssm	104	566	18.4%	cbioportal
24	KEAP1	Ssm	102	566	18%	cbioportal
25	PAPPA2	Ssm	101	566	17.8%	cbioportal
26	ADAMTS12	Ssm	99	566	17.5%	cbioportal
27	DNAH9	Ssm	99	566	17.5%	cbioportal
28	ADGRG4	Ssm	98	566	17.3%	cbioportal
29	RP1L1	Ssm	97	566	17.1%	cbioportal
30	RYR1	Ssm	95	566	16.8%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Lung Adenocarcinoma (TSP, Nature 2008) luad_tspTSP

163 cases with simple somatic mutation data · 163 cases total · 2026-01-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	64	163	39.3%	cbioportal
2	KRAS	Ssm	60	163	36.8%	cbioportal
3	STK11	Ssm	34	163	20.9%	cbioportal
4	EGFR	Ssm	30	163	18.4%	cbioportal
5	LRP1B	Ssm	16	163	9.8%	cbioportal
6	ATM	Ssm	13	163	8%	cbioportal
7	NF1	Ssm	13	163	8%	cbioportal
8	APC	Ssm	11	163	6.7%	cbioportal
9	EPHA3	Ssm	10	163	6.1%	cbioportal
10	CDKN2A	Ssm	9	163	5.5%	cbioportal
11	PTPRD	Ssm	9	163	5.5%	cbioportal
12	ERBB4	Ssm	8	163	4.9%	cbioportal
13	KDR	Ssm	8	163	4.9%	cbioportal
14	EPHA5	Ssm	7	163	4.3%	cbioportal
15	FGFR4	Ssm	7	163	4.3%	cbioportal
16	MYO3B	Ssm	7	163	4.3%	cbioportal
17	NTRK1	Ssm	7	163	4.3%	cbioportal
18	NTRK3	Ssm	7	163	4.3%	cbioportal
19	PRKDC	Ssm	7	163	4.3%	cbioportal
20	RB1	Ssm	7	163	4.3%	cbioportal
23	LTK	Ssm	6	163	3.7%	cbioportal
21	EPHA7	Ssm	6	163	3.7%	cbioportal
22	INSRR	Ssm	6	163	3.7%	cbioportal
24	NTRK2	Ssm	6	163	3.7%	cbioportal
25	PDGFRA	Ssm	6	163	3.7%	cbioportal
26	CDC42BPA	Ssm	5	163	3.1%	cbioportal
27	DOCK3	Ssm	5	163	3.1%	cbioportal
28	EPHB6	Ssm	5	163	3.1%	cbioportal
29	INHBA	Ssm	5	163	3.1%	cbioportal
30	JAK2	Ssm	5	163	3.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-07

Lung Cancer in Never Smokers (NCI, Nature Genetics 2021) lung_nci_2022NCI

232 cases with simple somatic mutation data · 232 cases total · 2026-01-16 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	EGFR	Ssm	66	232	28.4%	cbioportal
2	TP53	Ssm	36	232	15.5%	cbioportal
3	TTN	Ssm	21	232	9.1%	cbioportal
4	KRAS	Ssm	17	232	7.3%	cbioportal
5	RBM10	Ssm	17	232	7.3%	cbioportal
6	MUC16	Ssm	12	232	5.2%	cbioportal
7	LRRK2	Ssm	10	232	4.3%	cbioportal
9	SETD2	Ssm	10	232	4.3%	cbioportal
8	PIK3CA	Ssm	10	232	4.3%	cbioportal
14	UBA1	Ssm	9	232	3.9%	cbioportal
13	RYR2	Ssm	9	232	3.9%	cbioportal
12	REV3L	Ssm	9	232	3.9%	cbioportal
11	HUWE1	Ssm	9	232	3.9%	cbioportal
10	ERBB2	Ssm	9	232	3.9%	cbioportal
16	ZFHX4	Ssm	9	232	3.9%	cbioportal
15	XIRP2	Ssm	9	232	3.9%	cbioportal
18	CSMD1	Ssm	8	232	3.4%	cbioportal
17	BIRC6	Ssm	8	232	3.4%	cbioportal
20	LRP1B	Ssm	8	232	3.4%	cbioportal
19	CSMD3	Ssm	8	232	3.4%	cbioportal
26	FSIP2	Ssm	7	232	3%	cbioportal
24	DNAH5	Ssm	7	232	3%	cbioportal
23	ARID2	Ssm	7	232	3%	cbioportal
22	ARID1A	Ssm	7	232	3%	cbioportal
21	AR	Ssm	7	232	3%	cbioportal
28	MET	Ssm	7	232	3%	cbioportal
27	GLUD2	Ssm	7	232	3%	cbioportal
25	FBN2	Ssm	7	232	3%	cbioportal
30	ADGRV1	Ssm	6	232	2.6%	cbioportal
29	ADGRG4	Ssm	6	232	2.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-16

Non-Small Cell Cancer (MSK, Cancer Discov 2017) lung_msk_2017MSK

915 cases with simple somatic mutation data · 915 cases total · 2026-04-07 · mapped to Lung Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	485	915	53%	cbioportal
2	EGFR	Ssm	268	915	29.3%	cbioportal
3	KRAS	Ssm	241	915	26.3%	cbioportal
4	STK11	Ssm	157	915	17.2%	cbioportal
5	KEAP1	Ssm	153	915	16.7%	cbioportal
6	SMARCA4	Ssm	92	915	10.1%	cbioportal
7	PTPRD	Ssm	89	915	9.7%	cbioportal
8	RBM10	Ssm	78	915	8.5%	cbioportal
9	FAT1	Ssm	71	915	7.8%	cbioportal
10	ARID1A	Ssm	69	915	7.5%	cbioportal
11	NF1	Ssm	67	915	7.3%	cbioportal
12	PTPRT	Ssm	67	915	7.3%	cbioportal
14	PIK3CA	Ssm	65	915	7.1%	cbioportal
13	ATM	Ssm	65	915	7.1%	cbioportal
15	EPHA3	Ssm	59	915	6.4%	cbioportal
16	KMT2D	Ssm	58	915	6.3%	cbioportal
17	HGF	Ssm	56	915	6.1%	cbioportal
18	SETD2	Ssm	56	915	6.1%	cbioportal
19	KMT2C	Ssm	53	915	5.8%	cbioportal
20	ATRX	Ssm	52	915	5.7%	cbioportal
21	BRAF	Ssm	50	915	5.5%	cbioportal
22	EPHA5	Ssm	50	915	5.5%	cbioportal
23	RB1	Ssm	50	915	5.5%	cbioportal
42	ZFHX3	Ssm	34	623	5.5%	cbioportal
24	APC	Ssm	49	915	5.4%	cbioportal
25	CDKN2A	Ssm	49	915	5.4%	cbioportal
50	EPHA7	Ssm	31	623	5%	cbioportal
26	ARID2	Ssm	45	915	4.9%	cbioportal
27	NTRK3	Ssm	44	915	4.8%	cbioportal
55	MGA	Ssm	29	623	4.7%	cbioportal

Data updated 22 days agoSource updated 2026-04-07