Lung Non-Small Cell Carcinoma

In this study, 363 lung adenocarcinoma tumors of Indian origin were analyzed using targeted next-generation sequencing and mass spectrometry genotyping, and FGFR3 mutations were identified in 20 tumor… (full text at CIViC)

PMID 27998968 · Chandrani et al., 2017 · Open in CIViC

In a xenograft model, FGFR4 overexpressing HCC827 cells exhibited higher resistance to erlotinib. And also, H1975 cells showed resistance to erlotinib. The combination of erlotinib and FGFR1/2/3/4 inh… (full text at CIViC)

PMID 31027687 · Quintanal-Villalonga et al., 2019 · Open in CIViC

In a xenograft model, FGFR4 overexpressing HCC827 cells exhibited higher resistance to erlotinib. And also, H1975 cells showed resistance to erlotinib. The combination of erlotinib and FGFR1/2/3/4 inh… (full text at CIViC)

PMID 31027687 · Quintanal-Villalonga et al., 2019 · Open in CIViC

Targeting overactive GATA2-mediated pathways with inhibitors bortezomib and fasudil led to dramatic tumor regression.

PMID 22541434 · Kumar et al., 2012 · Open in CIViC

The disease control rate of patients with GNAS1 T393C CC genotype was lower than that of patients with variant genotype (TT or CT) (46.2% vs 73.8%, P=0.039). Univariate analysis identified gender, smo… (full text at CIViC)

PMID 24758907 · Hong et al., 2014 · Open in CIViC

In a preclinical study in an immunocompetent mouse model of lung adenocarcinoma, upregulation of alternative immune checkpoints, notably T-cell immunoglobulin mucin-3 (TIM-3, aka HAVCR2) was observed … (full text at CIViC)

PMID 26883990 · Koyama et al., 2016 · Open in CIViC

In a preclinical study in an immunocompetent mouse model of lung adenocarcinoma, upregulation of alternative immune checkpoints, notably T-cell immunoglobulin mucin-3 (TIM-3, aka HAVCR2) was observed … (full text at CIViC)

PMID 26883990 · Koyama et al., 2016 · Open in CIViC

Inhibition of mTOR or combined inhibition of MEK and mTOR reduced cell growth in a synergistic manner. Cells transformed with mutant HRAS isoforms Q61L, Q61R and G12V demonstrated equal sensitivity to… (full text at CIViC)

PMID 26544513 · Kiessling et al., 2015 · Open in CIViC

Expression of IGF1R in NSCLC cell lines (n=17) was associated with resistance to EGFR inhibitor gefitinib, however, knock-in or knock-out of IGF1R did not affect gefitinib sensitivity. IGF1R expressio… (full text at CIViC)

PMID 23619944 · Peled et al., 2013 · Open in CIViC

Overexpression of JAK1 in 22 lung cancer cell lines was associated with sensitivity to PKC-inhibitor enzastaurin. Silencing of JAK1 (by small molecule JAK 1/2/3 inhibitor) led to resistance. Overexpr… (full text at CIViC)

PMID 22333600 · Shimokawa et al., 2012 · Open in CIViC

Comprehensive genomic profiling on a tumor and germline sample from a patient with refractory lung adenocarcinoma who achieved marked long-term clinical benefit from anti-PD-L1 therapy. Two activating… (full text at CIViC)

PMID 26014096 · Van Allen et al., 2015 · Open in CIViC

Comprehensive genomic profiling on a tumor and germline sample from a patient with refractory lung adenocarcinoma who achieved marked long-term clinical benefit from anti-PD-L1 therapy. Two activating… (full text at CIViC)

PMID 26014096 · Van Allen et al., 2015 · Open in CIViC

The POSEIDON (NCT03164616) open-label, randomized phase 3 trial included 1,013 patients with metastatic non-small-cell lung cancer (NSCLC), of whom 637 had nonsquamous histology and 612 were evaluable… (full text at CIViC)

PMID 39385035 · Skoulidis et al., 2024 · Open in CIViC

A retrospective analysis of 871 non-squamous NSCLC patients treated with chemotherapy (platinum compound plus pemetrexed) combined with immunotherapy (pembrolizumab) found that those with KEAP1 mutati… (full text at CIViC)

PMID 39385035 · Skoulidis et al., 2024 · Open in CIViC

Case report of a 50-year-old male with Stage 1 Lung adenocarcinoma. NGS detected the presence of KIF5B::EGFR fusion (exon 15 and exon 18). The patient received two cycles of chemotherapy but experienc… (full text at CIViC)

PMID 34163176 · Wang et al., 2021 · Open in CIViC

This case study reports the first case of a KIF5B-EGFR fusion (KIF5B exon 15–EGFR exon 18) in primary lung adenocarcinoma. The patient showed a significant partial response to afatinib and bevacizumab… (full text at CIViC)

PMID 32903808 · Xu et al., 2020 · Open in CIViC

A 56 year old woman presents with poorly differentiated stage IIIC lung adenocarcinoma. Chemoradiotherapy and 12-month durvalumab was administered with significant response. 11 months after durvalumab… (full text at CIViC)

PMID 36033470 · Lin et al., 2022 · Open in CIViC

A patient with stage IV NSCLC were treated with CDDP+PEM+Bmab, CBDCA+GEM, pembrolizumab and SAIT301 (met inhibitor). After disease progression, she was received crizotinib and exhibited a dramatic res… (full text at CIViC)

PMID 29102694 · Cho et al., 2018 · Open in CIViC

Case report of a 74-year old woman with EGFR- and ALK-negative lung adenocarcinoma. FISH identified a deletion of 5'RET (FISH, indicating RET-gene rearrangement) and genomic testing confirmed a fusion… (full text at CIViC)

PMID 25982012 · Subbiah et al., 2015 · Open in CIViC

A patient with a KIF5B::RET fusion positive NSCLC with brain metastases who had acquired resistance to alectinib experienced a dramatic response to the selective RET inhibitor selpercatinib (LOXO-292)… (full text at CIViC)

PMID 29912274 · Subbiah et al., 2018 · Open in CIViC

We established inducible KIF5B-RET transgenic mice and KIF5B-RET-dependent cell lines for preclinical modeling of KIF5B-RET-associated lung adenocarcinoma. By culturing cells with increasing concentra… (full text at CIViC)

PMID 27496134 · Huang et al., 2016 · Open in CIViC

We established inducible KIF5B-RET transgenic mice and KIF5B-RET-dependent cell lines for preclinical modeling of KIF5B-RET-associated lung adenocarcinoma. By culturing cells with increasing concentra… (full text at CIViC)

PMID 27496134 · Huang et al., 2016 · Open in CIViC

A 61-year old patient with KIF5B-RET fusion positive NSCLC received clinical benefit from selpercatinib treatment initially. ctDNA surveillance showed the emergence of RET G810S 3 months after the sta… (full text at CIViC)

PMID 31988000 · Solomon et al., 2020 · Open in CIViC

A RET fusion-positive NSCLC patient who had been treated with multiple lines of chemotherapy and targeted therapies received selpercatinib. The patient initially tolerated selpercatinib achieving a sy… (full text at CIViC)

PMID 31988000 · Solomon et al., 2020 · Open in CIViC

We established inducible KIF5B-RET transgenic mice and KIF5B-RET-dependent cell lines for preclinical modeling of KIF5B-RET-associated lung adenocarcinoma. By culturing cells with increasing concentra… (full text at CIViC)

PMID 27496134 · Huang et al., 2016 · Open in CIViC

In a stage IV lung adenocarcinoma patient harboring a KIT D816G mutation, the KIT D816G mutation was associated with crizotinib resistance. The patient was initially found to harbor a ROS1 gene rearra… (full text at CIViC)

PMID 27068398 · Dziadziuszko et al., 2016 · Open in CIViC

Ba/F3 cells harboring the KIT L576P mutation are sensitive to nilotinib, imatinib and lower concentrations of dasatinib.

PMID 17372901 · Antonescu et al., 2007 · Open in CIViC

In a retrospective pan-cancer analysis of four immune checkpoint therapy (ICT)–treated cohorts (melanoma n = 287; NSCLC n = 131; total n = 418), KMT2 family mutations were associated with improved ICT… (full text at CIViC)

PMID 33653367 · Zhang et al., 2021 · Open in CIViC

In preclinical lung squamous cell carcinoma models, KMT2D loss increased sensitivity to SHP2 inhibition (SHP099) and pan-ERBB inhibition (afatinib). Enhanced growth suppression was observed in Kmt2d-d… (full text at CIViC)

PMID 36525973 · Pan et al., 2023 · Open in CIViC

In preclinical lung adenocarcinoma (LUAD) models, loss-of-function KMT2D (truncating/inactivating) was associated with greater sensitivity to glycolysis inhibition, most consistently 2-deoxy-D-glucose… (full text at CIViC)

PMID 32243837 · Alam et al., 2020 · Open in CIViC

Case report of a patient with metastatic lung adenocarcinoma. Whole exome sequencing of the metastatic tumor revealed KRAS A146V, STK11 frameshift deletion and ATM alteration. Preclinical evidence led… (full text at CIViC)

PMID 24836576 · Van Allen et al., 2014 · Open in CIViC

To characterize crizotinib resistant tumors, three patient cases with established MET exon 14 (METex14) mutant non-small cell lung cancer (NSCLC) samples were all found to have gained amplification of… (full text at CIViC)

PMID 30072474 · Bahcall et al., 2018 · Open in CIViC

To determine the origin of drug resistance in MET amplified cell lines, MET small-molecule inhibitors PHA-665752 or JNJ38877605 were tested in cell lines harboring MET amplification. In cell line GR15… (full text at CIViC)

PMID 20841479 · Cepero et al., 2010 · Open in CIViC

KRAS mutations in lung cancer patients are not associated with smoking history, age or gender.

PMID 18794081 · Riely et al., 2008 · Open in CIViC

There is no strong association between KRAS mutation status and overall or progression free survival in patients with NSCLC.

PMID 11208838 · Schiller et al., 2001 · Open in CIViC

In a prospective study of 522 European non-small cell lung cancer patients, patients with a KRAS exon 2 mutation (42/307) treated with erlotinib as a second-, third-line or more treatment were associa… (full text at CIViC)

PMID 22982650 · Cadranel et al., 2012 · Open in CIViC

KRAS mutations (N=29 G12, N=1 G13) were the primary predictor of EGFR TKI resistance in patients with lung adenocarcinoma (N=83). Overall survival (P=0.001) and progression-free survival (P=0.005) wer… (full text at CIViC)

PMID 19794967 · Marchetti et al., 2009 · Open in CIViC

In a study of 48 NSCLC patients, those with G12C or G12V mutant KRAS were associated with decreased progression free survival (1.84 months) compared with other KRAS mutants or with wild-type KRAS (3.3… (full text at CIViC)

PMID 22247021 · Ihle et al., 2012 · Open in CIViC

In the phase II cohort of the KRYSTAL-1 trial, 112 evaluable patients with previously treated advanced KRASG12C-mutated NSCLC were treated with adagrasib monotherapy (600-mg in capsule form twice dail… (full text at CIViC)

PMID 35658005 · Jänne et al., 2022 · Open in CIViC