KRAS A146V

CI-VAR-00000061Explore in graph →NP_004976.2:p.Ala146ValNM_004985.4:c.437C>TClinVar 375962 CIViC 322 rs1057519725

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 2 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Lung Non-Small Cell Carcinoma1
KRAS A146V	Abemaciclib	Predictive	C	Supports Sensitivity Response	2	accepted	EID794 Case report of a patient with metastatic lung adenocarcinoma. Whole exome sequencing of the metastatic tumor revealed KRAS A146V, STK11 frameshift deletion and ATM alteration. Preclinical evidence led… (full text at CIViC) PMID 24836576 · Van Allen et al., 2014 · Open in CIViC	civic
Malignant Colorectal Neoplasm2
KRAS A146V	Cetuximab + PD98059Substitutes	Predictive	D	Supports Resistance	3	submitted	EID12069 Colorectal cancer cell line HT29 was invected with KRAS lentivirus constructs for wildtype, A146V, A146T, A146P, and empty. Cells were treated with the anti-EGFR monoclonal antibody cetuximab, and MEK…

ClinVar

Clinical significance (1)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

clinvarCurated1 interpretation · review status and star rating as assigned by ClinVar.

Variation	Clinical significance	Review status	Stars	Conditions	Origin	Submitters	Last evaluated	Source
375962	Pathogenic/Likely pathogenic	criteria provided, multiple submitters, no conflicts	2	OCULOECTODERMAL SYNDROME, SOMATIC; Encephalocraniocutaneous lipomatosis; RASopathy; Malignant tumor of urinary bladder; Familial pancreatic carcinoma; KRAS-related disorder	germline/somatic	8	Jan 01, 2026	clinvar