Cancer Family
Genitourinary System Neoplasm
CI-CAN-00000018Explore in graph →
Non-malignant3,846 active trials61 approved drugs306 evidence items
- NCIt
- C156482
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Cancer Family
CI-CAN-00000018Explore in graph →
Genomics
114 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
130 cases with simple somatic mutation data · 131 cases total · 2026-01-05 · mapped to Bladder Urothelial Carcinoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | TTN |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 72 |
| 130 |
| 55.4% |
| cbioportal |
| 2 | TP53 | Ssm | 64 | 130 | 49.2% | cbioportal |
| 3 | MUC16 | Ssm | 43 | 130 | 33.1% | cbioportal |
| 4 | KMT2D | Ssm | 35 | 130 | 26.9% | cbioportal |
| 5 | ARID1A | Ssm | 33 | 130 | 25.4% | cbioportal |
| 6 | KDM6A | Ssm | 31 | 130 | 23.8% | cbioportal |
| 7 | KMT2C | Ssm | 28 | 130 | 21.5% | cbioportal |
| 8 | PIK3CA | Ssm | 26 | 130 | 20% | cbioportal |
| 9 | FLG | Ssm | 25 | 130 | 19.2% | cbioportal |
| 11 | SYNE1 | Ssm | 24 | 130 | 18.5% | cbioportal |
| 10 | HMCN1 | Ssm | 24 | 130 | 18.5% | cbioportal |
| 13 | RYR2 | Ssm | 20 | 130 | 15.4% | cbioportal |
| 12 | EP300 | Ssm | 20 | 130 | 15.4% | cbioportal |
| 16 | PDE4DIP | Ssm | 19 | 130 | 14.6% | cbioportal |
| 17 | PKHD1L1 | Ssm | 19 | 130 | 14.6% | cbioportal |
| 14 | AHNAK2 | Ssm | 19 | 130 | 14.6% | cbioportal |
| 18 | ZFHX4 | Ssm | 19 | 130 | 14.6% | cbioportal |
| 15 | MACF1 | Ssm | 19 | 130 | 14.6% | cbioportal |
| 19 | CDKN1A | Ssm | 18 | 130 | 13.8% | cbioportal |
| 22 | SYNE2 | Ssm | 18 | 130 | 13.8% | cbioportal |
| 21 | LRP1B | Ssm | 18 | 130 | 13.8% | cbioportal |
| 20 | KMT2A | Ssm | 18 | 130 | 13.8% | cbioportal |
| 24 | MUC17 | Ssm | 17 | 130 | 13.1% | cbioportal |
| 25 | RB1 | Ssm | 17 | 130 | 13.1% | cbioportal |
| 23 | LYST | Ssm | 17 | 130 | 13.1% | cbioportal |
| 30 | DNAH3 | Ssm | 16 | 130 | 12.3% | cbioportal |
| 26 | ADGRV1 | Ssm | 16 | 130 | 12.3% | cbioportal |
| 27 | CREBBP | Ssm | 16 | 130 | 12.3% | cbioportal |
| 33 | FGFR3 | Ssm | 16 | 130 | 12.3% | cbioportal |
| 32 | FAT4 | Ssm | 16 | 130 | 12.3% | cbioportal |
Data updated 22 days agoSource updated 2026-01-05