Subtype
Gastrointestinal Stromal Tumor of the Gastrointestinal Tract
CI-CAN-00000919Explore in graph →
Non-malignant2 active trials
- NCIt
- C35778
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Subtype
CI-CAN-00000919Explore in graph →
Data completeness1 / 7 dimensions
Computed from entity_counters.completeness · refreshed after each connector run
Definition
A stromal tumor that originates from the interstitial cells of Cajal. It may involve any part of the gastrointestinal tract. The majority of cases occur in the stomach. Morphologic variants include the epithelioid cell type, spindle cell type, and mixed cell type. Most cases contain KIT- or PDGFRA-activating mutations. Lesions with a diameter greater than 10cm and more than 5 mitotic figures per 50HPF tend to have a more aggressive clinical course. Until recently, surgery has been the only effective therapy for this tumor. However, many patients still experience recurrence. A KIT tyrosine kinase inhibitor, imatinib mesylate (also known as STI-571 or Gleevec), is now effective in the treatment of relapsed and unresectable cases.
Data updated 22 days agoSource updated 26.08e
Taxonomy
Several hierarchies coexist; edges are listed per hierarchy type with their source.
Parents
14 descendants in total; counters on this page aggregate over all of them.
Anatomy
Data updated 19 hours agoSource updated unknowncounters aggregate over descendants
Names
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Key figures
Each figure carries its unit, period and source; ranks link to "Why this rank?".
No registry-level ancestor: burden figures are published for the mutually exclusive top-level site groups only, and this entity does not descend from one. Global figures (IARC / GLOBOCAN) stay under license review and SEER awaits credentials.
Data updated 19 hours agoSource updated unknownregistry figures: none · counters aggregate over descendants