Gastric Adenocarcinoma — Genomics

Gastric Adenocarcinoma — Genomics · CancerIndex

Genomics

Gene alteration frequencies by cohort

9 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.

Gastric Cancer (OncoSG, 2018) stad_oncosg_2018OncoSG

147 cases with simple somatic mutation data · 147 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53

Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.

Stomach Adenocarcinoma TCGA-STADTCGA

443 cases with simple somatic mutation data · 443 cases total · Data Release 46.0 · mapped to Gastric Adenocarcinoma ALIAS

gdcObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	CSMD3	Ssm	305	443	68.8%	gdc
2	RIMS2	Ssm	302	443	68.2%	gdc
3	FER1L6	Ssm	299	443	67.5%	gdc
4	TTN	Ssm	297	443	67%	gdc
5	MYC	Ssm	296	443	66.8%	gdc
7	TG	Ssm	295	443	66.6%	gdc
6	ADCY8	Ssm	295	443	66.6%	gdc
8	POU5F1B	Ssm	294	443	66.4%	gdc
9	ASAP1	Ssm	293	443	66.1%	gdc
11	UBR5	Ssm	293	443	66.1%	gdc
10	LRP12	Ssm	293	443	66.1%	gdc
12	DDX27	Ssm	292	443	65.9%	gdc
15	COL14A1	Ssm	290	443	65.5%	gdc
14	ZNF831	Ssm	290	443	65.5%	gdc
13	VPS13B	Ssm	290	443	65.5%	gdc
17	NFATC2	Ssm	289	443	65.2%	gdc
19	PLEC	Ssm	289	443	65.2%	gdc
18	DIDO1	Ssm	289	443	65.2%	gdc
16	GSDMC	Ssm	289	443	65.2%	gdc
23	KLHL38	Ssm	288	443	65%	gdc
21	WASHC5	Ssm	288	443	65%	gdc
20	PKHD1L1	Ssm	288	443	65%	gdc
22	ANXA13	Ssm	288	443	65%	gdc
30	LRATD2	Ssm	287	443	64.8%	gdc
26	ATAD2	Ssm	287	443	64.8%	gdc
25	EXT1	Ssm	287	443	64.8%	gdc
24	FAM91A1	Ssm	287	443	64.8%	gdc
28	SQLE	Ssm	287	443	64.8%	gdc
29	PTPRT	Ssm	287	443	64.8%	gdc
27	FBXO32	Ssm	287	443	64.8%	gdc

Data updated 22 days agoSource updated Data Release 46.0

Stomach Adenocarcinoma (Pfizer and UHK, Nat Genet 2014) stad_pfizer_uhongkongPfizer and UHK

100 cases with simple somatic mutation data · 100 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	55	100	55%	cbioportal
2	TTN	Ssm	41	100	41%	cbioportal
3	MUC16	Ssm	24	100	24%	cbioportal
4	SYNE1	Ssm	22	100	22%	cbioportal
5	CSMD1	Ssm	19	100	19%	cbioportal
6	ARID1A	Ssm	18	100	18%	cbioportal
7	FLG	Ssm	17	100	17%	cbioportal
8	DNAH5	Ssm	16	100	16%	cbioportal
9	CDH1	Ssm	15	100	15%	cbioportal
10	FAT3	Ssm	14	100	14%	cbioportal
11	HYDIN	Ssm	14	100	14%	cbioportal
12	LRP1B	Ssm	14	100	14%	cbioportal
13	DNAH14	Ssm	13	100	13%	cbioportal
14	KMT2C	Ssm	13	100	13%	cbioportal
15	OBSCN	Ssm	13	100	13%	cbioportal
16	RYR3	Ssm	13	100	13%	cbioportal
17	SPTA1	Ssm	13	100	13%	cbioportal
18	SDK1	Ssm	12	100	12%	cbioportal
19	ABCA13	Ssm	11	100	11%	cbioportal
20	CACNA1C	Ssm	11	100	11%	cbioportal
21	COBLL1	Ssm	11	100	11%	cbioportal
22	HRNR	Ssm	11	100	11%	cbioportal
23	MDN1	Ssm	11	100	11%	cbioportal
24	PCLO	Ssm	11	100	11%	cbioportal
25	PREX2	Ssm	11	100	11%	cbioportal
26	RNF43	Ssm	11	100	11%	cbioportal
27	RYR1	Ssm	11	100	11%	cbioportal
28	SYNE2	Ssm	11	100	11%	cbioportal
29	TGFBR2	Ssm	11	100	11%	cbioportal
30	XIRP2	Ssm	11	100	11%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (TCGA, Firehose Legacy) stad_tcgaTCGA

478 cases with simple somatic mutation data · 478 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	217	478	45.4%	cbioportal
2	TP53	Ssm	190	478	39.7%	cbioportal
3	MUC16	Ssm	134	478	28%	cbioportal
4	LRP1B	Ssm	104	478	21.8%	cbioportal
5	ARID1A	Ssm	102	478	21.3%	cbioportal
6	SYNE1	Ssm	101	478	21.1%	cbioportal
7	OBSCN	Ssm	95	478	19.9%	cbioportal
8	FLG	Ssm	86	478	18%	cbioportal
9	FAT4	Ssm	85	478	17.8%	cbioportal
10	CSMD1	Ssm	84	478	17.6%	cbioportal
11	PCLO	Ssm	80	478	16.7%	cbioportal
12	RYR2	Ssm	77	478	16.1%	cbioportal
13	DNAH5	Ssm	73	478	15.3%	cbioportal
14	FAT3	Ssm	73	478	15.3%	cbioportal
15	HMCN1	Ssm	73	478	15.3%	cbioportal
16	KMT2D	Ssm	69	478	14.4%	cbioportal
17	SPTA1	Ssm	69	478	14.4%	cbioportal
18	ZFHX4	Ssm	69	478	14.4%	cbioportal
19	PIK3CA	Ssm	65	478	13.6%	cbioportal
20	HSPG2	Ssm	63	478	13.2%	cbioportal
21	DNAH7	Ssm	62	478	13%	cbioportal
22	PCDH15	Ssm	61	478	12.8%	cbioportal
23	RYR3	Ssm	61	478	12.8%	cbioportal
24	SACS	Ssm	60	478	12.6%	cbioportal
25	ACVR2A	Ssm	59	478	12.3%	cbioportal
26	DNAH11	Ssm	59	478	12.3%	cbioportal
27	LRRK2	Ssm	59	478	12.3%	cbioportal
28	USH2A	Ssm	59	478	12.3%	cbioportal
29	AHNAK2	Ssm	58	478	12.1%	cbioportal
30	CUBN	Ssm	58	478	12.1%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (TCGA GDC, 2025) stad_tcga_gdcTCGA GDC

431 cases with simple somatic mutation data · 443 cases total · 2026-01-14 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	221	431	51.3%	cbioportal
2	TP53	Ssm	198	431	45.9%	cbioportal
3	MUC16	Ssm	135	431	31.3%	cbioportal
4	ARID1A	Ssm	116	431	26.9%	cbioportal
5	LRP1B	Ssm	115	431	26.7%	cbioportal
6	CSMD3	Ssm	102	431	23.7%	cbioportal
7	SYNE1	Ssm	102	431	23.7%	cbioportal
8	FAT4	Ssm	92	431	21.3%	cbioportal
9	FLG	Ssm	85	431	19.7%	cbioportal
10	PCLO	Ssm	81	431	18.8%	cbioportal
11	HMCN1	Ssm	80	431	18.6%	cbioportal
12	ACVR2A	Ssm	77	431	17.9%	cbioportal
13	ZFHX4	Ssm	77	431	17.9%	cbioportal
14	DNAH5	Ssm	76	431	17.6%	cbioportal
16	SPTA1	Ssm	74	431	17.2%	cbioportal
15	OBSCN	Ssm	74	431	17.2%	cbioportal
17	RYR2	Ssm	73	431	16.9%	cbioportal
18	CSMD1	Ssm	71	431	16.5%	cbioportal
19	FAT3	Ssm	71	431	16.5%	cbioportal
20	KMT2D	Ssm	68	431	15.8%	cbioportal
21	PIK3CA	Ssm	67	431	15.5%	cbioportal
22	DST	Ssm	66	431	15.3%	cbioportal
23	SACS	Ssm	65	431	15.1%	cbioportal
25	PLEC	Ssm	62	431	14.4%	cbioportal
24	PCDH15	Ssm	62	431	14.4%	cbioportal
26	DMD	Ssm	61	431	14.2%	cbioportal
27	LRRK2	Ssm	60	431	13.9%	cbioportal
29	UBR5	Ssm	59	431	13.7%	cbioportal
28	SYNE2	Ssm	59	431	13.7%	cbioportal
30	COL12A1	Ssm	58	431	13.5%	cbioportal

Data updated 22 days agoSource updated 2026-01-14

Stomach Adenocarcinoma (TCGA, Nature 2014) stad_tcga_pubTCGA

295 cases with simple somatic mutation data · 295 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	166	295	56.3%	cbioportal
2	TP53	Ssm	138	295	46.8%	cbioportal
3	MUC16	Ssm	101	295	34.2%	cbioportal
4	ARID1A	Ssm	90	295	30.5%	cbioportal
5	LRP1B	Ssm	78	295	26.4%	cbioportal
6	SYNE1	Ssm	76	295	25.8%	cbioportal
7	FAT4	Ssm	70	295	23.7%	cbioportal
8	CSMD3	Ssm	68	295	23.1%	cbioportal
9	PCLO	Ssm	67	295	22.7%	cbioportal
10	HMCN1	Ssm	66	295	22.4%	cbioportal
11	CSMD1	Ssm	65	295	22%	cbioportal
12	KMT2D	Ssm	65	295	22%	cbioportal
13	FLG	Ssm	62	295	21%	cbioportal
14	RYR2	Ssm	59	295	20%	cbioportal
16	SPTA1	Ssm	57	295	19.3%	cbioportal
15	PIK3CA	Ssm	57	295	19.3%	cbioportal
18	FAT3	Ssm	56	295	19%	cbioportal
17	DNAH5	Ssm	56	295	19%	cbioportal
19	OBSCN	Ssm	55	295	18.6%	cbioportal
20	ZFHX4	Ssm	53	295	18%	cbioportal
21	RYR3	Ssm	50	295	16.9%	cbioportal
23	RNF43	Ssm	49	295	16.6%	cbioportal
22	PCDH15	Ssm	49	295	16.6%	cbioportal
25	PLEC	Ssm	48	295	16.3%	cbioportal
24	ADGRV1	Ssm	48	295	16.3%	cbioportal
26	DMD	Ssm	47	295	15.9%	cbioportal
27	SACS	Ssm	47	295	15.9%	cbioportal
28	COL12A1	Ssm	46	295	15.6%	cbioportal
29	RYR1	Ssm	46	295	15.6%	cbioportal
30	TSPOAP1	Ssm	46	295	15.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (TCGA, PanCancer Atlas) stad_tcga_pan_can_atlas_2018TCGA

436 cases with simple somatic mutation data · 440 cases total · 2026-06-04 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TTN	Ssm	235	436	53.9%	cbioportal
2	TP53	Ssm	213	436	48.9%	cbioportal
3	MUC16	Ssm	146	436	33.5%	cbioportal
4	LRP1B	Ssm	120	436	27.5%	cbioportal
5	SYNE1	Ssm	111	436	25.5%	cbioportal
6	ARID1A	Ssm	110	436	25.2%	cbioportal
7	CSMD3	Ssm	107	436	24.5%	cbioportal
8	FLG	Ssm	103	436	23.6%	cbioportal
9	FAT4	Ssm	94	436	21.6%	cbioportal
10	CSMD1	Ssm	88	436	20.2%	cbioportal
11	PCLO	Ssm	88	436	20.2%	cbioportal
12	HMCN1	Ssm	86	436	19.7%	cbioportal
13	OBSCN	Ssm	81	436	18.6%	cbioportal
14	DNAH5	Ssm	80	436	18.3%	cbioportal
16	ZFHX4	Ssm	79	436	18.1%	cbioportal
15	RYR2	Ssm	79	436	18.1%	cbioportal
18	SPTA1	Ssm	77	436	17.7%	cbioportal
17	FAT3	Ssm	77	436	17.7%	cbioportal
19	KMT2D	Ssm	73	436	16.7%	cbioportal
20	PCDH15	Ssm	72	436	16.5%	cbioportal
21	PIK3CA	Ssm	71	436	16.3%	cbioportal
22	AHNAK2	Ssm	68	436	15.6%	cbioportal
23	PLEC	Ssm	64	436	14.7%	cbioportal
24	SACS	Ssm	64	436	14.7%	cbioportal
29	RYR3	Ssm	62	436	14.2%	cbioportal
28	LAMA1	Ssm	62	436	14.2%	cbioportal
27	DNAH11	Ssm	62	436	14.2%	cbioportal
26	CUBN	Ssm	62	436	14.2%	cbioportal
25	COL12A1	Ssm	62	436	14.2%	cbioportal
30	USH2A	Ssm	62	436	14.2%	cbioportal

Data updated 22 days agoSource updated 2026-06-04

Stomach Adenocarcinoma (UHK, Nat Genet 2011) stad_uhongkongUHK

22 cases with simple somatic mutation data · 22 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	9	22	40.9%	cbioportal
2	DNAH7	Ssm	7	22	31.8%	cbioportal
3	ARID1A	Ssm	6	22	27.3%	cbioportal
4	CSMD3	Ssm	6	22	27.3%	cbioportal
5	LRP1B	Ssm	6	22	27.3%	cbioportal
6	PTEN	Ssm	6	22	27.3%	cbioportal
7	SLCO6A1	Ssm	6	22	27.3%	cbioportal
8	PCDH15	Ssm	5	22	22.7%	cbioportal
9	TTN	Ssm	5	22	22.7%	cbioportal
17	HMCN1	Ssm	4	22	18.2%	cbioportal
10	ACVR2A	Ssm	4	22	18.2%	cbioportal
11	BAZ2B	Ssm	4	22	18.2%	cbioportal
12	COPB2	Ssm	4	22	18.2%	cbioportal
13	DNAH3	Ssm	4	22	18.2%	cbioportal
14	EIF3A	Ssm	4	22	18.2%	cbioportal
15	FMN2	Ssm	4	22	18.2%	cbioportal
16	HERC2	Ssm	4	22	18.2%	cbioportal
18	LMAN1	Ssm	4	22	18.2%	cbioportal
19	PAPPA	Ssm	4	22	18.2%	cbioportal
20	SPTA1	Ssm	4	22	18.2%	cbioportal
21	SYNE2	Ssm	4	22	18.2%	cbioportal
22	TIAM1	Ssm	4	22	18.2%	cbioportal
23	TTK	Ssm	4	22	18.2%	cbioportal
24	USH2A	Ssm	4	22	18.2%	cbioportal
25	USP34	Ssm	4	22	18.2%	cbioportal
26	ABCA7	Ssm	3	22	13.6%	cbioportal
27	ABCA8	Ssm	3	22	13.6%	cbioportal
28	ABCB5	Ssm	3	22	13.6%	cbioportal
29	ADAMTS18	Ssm	3	22	13.6%	cbioportal
30	ANK3	Ssm	3	22	13.6%	cbioportal

Data updated 22 days agoSource updated 2026-01-13

Stomach Adenocarcinoma (U Tokyo, Nat Genet 2014) stad_utokyoU Tokyo

30 cases with simple somatic mutation data · 30 cases total · 2026-01-13 · mapped to Gastric Adenocarcinoma EXACT_IDENTIFIER

cbioportalObserved30 genes · frequency = affected / profiled, as published by the cohort.

#	Gene	Alteration	Affected (n)	Profiled (n)	Frequency (%)	Source
1	TP53	Ssm	10	30	33.3%	cbioportal
2	TTN	Ssm	8	30	26.7%	cbioportal
3	RHOA	Ssm	7	30	23.3%	cbioportal
4	ARID1A	Ssm	5	30	16.7%	cbioportal
5	CACNA1H	Ssm	4	30	13.3%	cbioportal
6	CDC27	Ssm	4	30	13.3%	cbioportal
7	CDH1	Ssm	4	30	13.3%	cbioportal
8	KIF2B	Ssm	4	30	13.3%	cbioportal
9	MUC16	Ssm	4	30	13.3%	cbioportal
10	MYT1L	Ssm	4	30	13.3%	cbioportal
11	SPTA1	Ssm	4	30	13.3%	cbioportal
12	COL12A1	Ssm	3	30	10%	cbioportal
13	CRB1	Ssm	3	30	10%	cbioportal
14	CSMD1	Ssm	3	30	10%	cbioportal
15	CYP7B1	Ssm	3	30	10%	cbioportal
16	DMD	Ssm	3	30	10%	cbioportal
17	DYNC2H1	Ssm	3	30	10%	cbioportal
18	GRM5	Ssm	3	30	10%	cbioportal
19	HEATR5B	Ssm	3	30	10%	cbioportal
20	KCNT2	Ssm	3	30	10%	cbioportal
21	NCKAP5	Ssm	3	30	10%	cbioportal
22	NF1	Ssm	3	30	10%	cbioportal
23	PLXNA4	Ssm	3	30	10%	cbioportal
24	RYR2	Ssm	3	30	10%	cbioportal
25	SRRM4	Ssm	3	30	10%	cbioportal
26	STAB1	Ssm	3	30	10%	cbioportal
27	SYNE1	Ssm	3	30	10%	cbioportal
28	TENM1	Ssm	3	30	10%	cbioportal
29	TLL1	Ssm	3	30	10%	cbioportal
30	TPRXL	Ssm	3	30	10%	cbioportal

Data updated 22 days agoSource updated 2026-01-13