Subtype
Digestive System Adenocarcinoma
CI-CAN-00002525Explore in graph →
1,374 active trials24 approved drugs77 evidence items
- NCIt
- C210140
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Subtype
CI-CAN-00002525Explore in graph →
Clinical trials
5,072 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
Computedformula ci-trial-intel-v1 · interventional studies · entity + NCIt descendants · hover a figure for its formulaCompare cancersTerminated studies (619)
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT03071458 | Mutational Landscape in Hepatocellular Carcinoma(MUTHEC) | completed | — | 808 | Institut National de la Santé Et de la Recherche Médicale, FranceOTHER_GOV | 1 | Dec 10, 2025 | clinicaltrials |
| NCT07272265 | The Effectiveness and Safety in High-risk Patients Receiving First-line Atezolizumab and Bevacizumab Combined With HAIC for HCC: a Retrospective Study | completed | N/A | 300 | Sun Yat-sen UniversityOTHER |
| 1 |
| Dec 9, 2025 |
| clinicaltrials |
| NCT02921256 | Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer | completed | Phase 2 | 363 | National Cancer Institute (NCI)NIH | 2 | Dec 4, 2025 | clinicaltrials |
| NCT03963206 | Cabozantinib toLERANCE Study in HepatoCellular Carcinoma (CLERANCE)(CLERANCE) | completed | Phase 4 | 110 | Hospices Civils de LyonOTHER | 1 | Dec 1, 2025 | clinicaltrials |
| NCT05795595 | A Safety and Efficacy Study Evaluating CTX131 in Adult Subjects With Relapsed or Refractory Solid Tumors | completed | Phase 1 / Phase 2 | 19 | CRISPR Therapeutics AGINDUSTRY | 1 | Nov 26, 2025 | clinicaltrials |
| NCT07244471 | Water-injecting Endoscopic Submucosal Dissection for Early Gastric Cancer: a Retrospective Cohort Study | completed | — | 548 | Shanghai East HospitalOTHER | 1 | Nov 24, 2025 | clinicaltrials |
| NCT03193190 | A Study of Multiple Immunotherapy-Based Treatment Combinations in Participants With Metastatic Pancreatic Ductal Adenocarcinoma (Morpheus-Pancreatic Cancer) | completed | Phase 1 / Phase 2 | 341 | Hoffmann-La RocheINDUSTRY | 5 | Nov 21, 2025 | clinicaltrials |
| NCT05384184 | Next Generation " Pre-clinical Model for Colorectal Cancer Metastases and Hepatocellular Carcinomas(BORG) | completed | — | 48 | Assistance Publique Hopitaux De MarseilleOTHER | 1 | Nov 20, 2025 | clinicaltrials |
| NCT04828486 | Futibatinib and Pembrolizumab for Treatment of Advanced or Metastatic FGF19 Positive BCLC Stage A, B, or C Liver Cancer | completed | Phase 2 | 14 | Mayo ClinicOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT06294808 | Predicting Survival After Surgical Resection for the Entire Spectrum of Anatomically Resectable HCC | completed | — | 1,043 | National Cancer Centre, SingaporeOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT06614439 | PG Versus TG for Advanced PGC | completed | N/A | 96 | National Taiwan University HospitalOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT07153783 | Interventional AI-Human Collaboration for Liver Tumor Diagnosis | completed | N/A | 10,333 | Shengjing HospitalOTHER | 1 | Nov 18, 2025 | clinicaltrials |
| NCT05622071 | Testing Immunotherapy for Patients With Liver Cancer and Moderately Altered Liver Functions(HESTIA) | completed | Phase 2 | 50 | UNICANCEROTHER | 1 | Nov 17, 2025 | clinicaltrials |
| NCT04874519 | Registry to Collect Health Information Related to Fibrolamellar Cancer | completed | — | 12 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Nov 12, 2025 | clinicaltrials |
| NCT00183885 | A Phase II Study of Intra-arterial Chemotherapy With Cisplatin and Mitomycin-C in Patients With Hepatocellular Carcinoma | completed | Phase 2 | 76 | University of Southern CaliforniaOTHER | 1 | Oct 30, 2025 | clinicaltrials |
| NCT04208958 | Study of VE800 and Nivolumab in Patients With Selected Types of Advanced or Metastatic Cancer(ConsortiumIO) | completed | Phase 1 / Phase 2 | 56 | Vedanta Biosciences, Inc.INDUSTRY | 1 | Oct 27, 2025 | clinicaltrials |
| NCT05091346 | A Study of E7386 in Combination With Pembrolizumab in Previously Treated Participants With Selected Solid Tumors | completed | Phase 1 / Phase 2 | 89 | Eisai Inc.INDUSTRY | 4 | Oct 24, 2025 | clinicaltrials |
| NCT04408105 | Survey Study on Barrett's Esophagus Screening(SCREEN-BE) | completed | — | 725 | University of Colorado, DenverOTHER | 1 | Oct 22, 2025 | clinicaltrials |
| NCT02159989 | Sapanisertib and Ziv-Aflibercept in Treating Patients With Recurrent Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery | completed | Phase 1 | 83 | National Cancer Institute (NCI)NIH | 1 | Oct 20, 2025 | clinicaltrials |
| NCT03412773 | A Study of Tislelizumab Versus Sorafenib in Participants With Unresectable Hepatocellular Carcinoma (HCC) | completed | Phase 3 | 684 | BeiGeneINDUSTRY | 11 | Oct 14, 2025 | clinicaltrials |
| NCT05293496 | A Study of MGC018 in Combination With MGD019 in Participants With Advanced Solid Tumors | completed | Phase 1 | 31 | MacroGenicsINDUSTRY | 1 | Oct 14, 2025 | clinicaltrials |
| NCT03404960 | Niraparib + Ipilimumab or Nivolumab in Progression Free Pancreatic Adenocarcinoma After Platinum-Based Chemotherapy(Parpvax) | completed | Phase 1 / Phase 2 | 104 | University of PennsylvaniaOTHER | 1 | Oct 10, 2025 | clinicaltrials |
| NCT02799212 | Evaluation of Postoperative Ascites After Somatostatin Infusion Following Hepatectomy for Hepatocellular Carcinoma(SOMAPROTECT01) | completed | Phase 3 | 179 | Hospices Civils de LyonOTHER | 1 | Oct 3, 2025 | clinicaltrials |
| NCT05051475 | Endoscopic Radiofrequency Ablation Versus Hybrid Argon Plasma Coagulation in the Treatment of Barrett's Esophagus(RATE) | completed | N/A | 62 | Centre of Postgraduate Medical EducationOTHER | 1 | Oct 3, 2025 | clinicaltrials |
| NCT02738294 | Necessity Assessment of ME-NBI Targeted Biopsy Compared With EFB | completed | N/A | 211 | Shanghai Jiao Tong University School of MedicineOTHER | 1 | Oct 2, 2025 | clinicaltrials |
| NCT03044587 | Nal-IRI With 5-fluorouracil (5-FU) and Leucovorin or Gemcitabine Plus Cisplatin in Advanced Biliary-tract Cancer(NIFE) | completed | Phase 2 | 93 | AIO-Studien-gGmbHOTHER | 1 | Oct 1, 2025 | clinicaltrials |
| NCT03062358 | Study of Pembrolizumab (MK-3475) or Placebo Given With Best Supportive Care in Asian Participants With Previously Treated Advanced Hepatocellular Carcinoma (MK-3475-394/KEYNOTE-394) | completed | Phase 3 | 453 | Merck Sharp & Dohme LLCINDUSTRY | 5 | Sep 30, 2025 | clinicaltrials |
| NCT04257448 | Safety and Tolerance of Epigenetic and Immunomodulating Drugs Combined With Chemotherapeutics in Patients Suffering From Advanced Pancreatic Cancer(SEPION) | completed | Phase 1 / Phase 2 | 75 | GWT-TUD GmbHOTHER | 1 | Sep 30, 2025 | clinicaltrials |
| NCT06230328 | Brazilian Reality of Hepatocellular Carcinoma(BRA-HEP) | completed | — | 300 | AstraZenecaINDUSTRY | 1 | Sep 29, 2025 | clinicaltrials |
| NCT05351983 | Patient-derived Organoids Drug Screen in Pancreatic Cancer | completed | N/A | 60 | Prof. Dr. med. Dres. h.c. Jan Schmidt, MMEOTHER | 1 | Sep 25, 2025 | clinicaltrials |
| NCT04487067 | A Study of Atezolizumab (Tecentriq) in Combination With Bevacizumab to Investigate Safety and Efficacy in Patients With Unresectable Hepatocellular Carcinoma Not Previously Treated With Systemic Therapy-Amethista(AMETHISTA) | completed | Phase 3 | 152 | Hoffmann-La RocheINDUSTRY | 1 | Sep 22, 2025 | clinicaltrials |
| NCT06358001 | EchoTip AcuCore Post-Market Clinical Study | completed | — | 183 | Cook Research IncorporatedINDUSTRY | 1 | Sep 22, 2025 | clinicaltrials |
| NCT07184424 | Real-world Study of Lenalidomide After First-line Treatment Lenvatinib With PD-1 in Advanced HCC(Lenalidomide) | completed | N/A | 24 | Beijing Tsinghua Chang Gung HospitalOTHER | 1 | Sep 19, 2025 | clinicaltrials |
| NCT04344795 | Phase 1a/1b Study of TPST-1495 as a Single Agent and in Combination With Pembrolizumab in Subjects With Solid Tumors | completed | Phase 1 | 89 | Tempest TherapeuticsINDUSTRY | 1 | Sep 12, 2025 | clinicaltrials |
| NCT07167147 | Survival Outcomes by Tumor-Node Stage and Recurrence Patterns in Colon Cancer After Radical Surgery(STARS) | completed | — | 7,259 | Chang Gung Memorial HospitalOTHER | 1 | Sep 11, 2025 | clinicaltrials |
| NCT04264260 | Evaluation the Palliative Effects of Colchicine on Primary Hepatic Malignant Tumors Unable to Receive Curative Treatment | completed | Phase 2 | 42 | Kaohsiung Medical University Chung-Ho Memorial HospitalOTHER | 1 | Sep 8, 2025 | clinicaltrials |
| NCT07160374 | ThinkRadial: A Prospective Study of Transradial deTACE in HCC Patients(ThinkRADIAL) | completed | — | 38 | Asan Medical CenterOTHER | 1 | Sep 8, 2025 | clinicaltrials |
| NCT04853017 | A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors(AMPLIFY-201) | completed | Phase 1 | 25 | Elicio TherapeuticsINDUSTRY | 1 | Sep 5, 2025 | clinicaltrials |
| NCT05197504 | Predictive Biomarkers in Patients With Advanced Hepatocellular Carcinoma Treated With Systemic Therapy(HCC) | completed | — | 166 | CHA UniversityOTHER | 1 | Sep 5, 2025 | clinicaltrials |
| NCT07157085 | AI Multitask Model for HCC Treatment | completed | — | 7,000 | Sun Yat-sen UniversityOTHER | 1 | Sep 5, 2025 | clinicaltrials |
| NCT03037437 | Sorafenib Induced Autophagy Using Hydroxychloroquine in Hepatocellular Cancer | completed | Phase 2 | 64 | The University of Texas Health Science Center at San AntonioOTHER | 1 | Sep 4, 2025 | clinicaltrials |
| NCT03724994 | Chemotherapy, Host Response and Molecular Dynamics in Periampullary Cancer(CHAMP) | completed | — | 201 | Lund UniversityOTHER | 1 | Aug 29, 2025 | clinicaltrials |
| NCT04772989 | A Study to Evaluate AB308 in Combination With AB122 in Participants With Advanced Malignancies(ARC-12) | completed | Phase 1 | 94 | Arcus Biosciences, Inc.INDUSTRY | 3 | Aug 28, 2025 | clinicaltrials |
| NCT07143955 | Dietary Intervention and Gut Microbiota in Hepatocellular Carcinoma (HCC) | completed | N/A | 100 | The First Hospital of Hebei Medical UniversityOTHER | 1 | Aug 27, 2025 | clinicaltrials |
| NCT04191421 | Siltuximab and Spartalizumab in Patients With Metastatic Pancreatic Cancer | completed | Phase 1 / Phase 2 | 35 | Emory UniversityOTHER | 1 | Aug 22, 2025 | clinicaltrials |
| NCT03638141 | CTLA-4 /PD-L1 Blockade Following Transarterial Chemoembolization (DEB-TACE) in Patients With Intermediate Stage of HCC (Hepatocellular Carcinoma) Using Durvalumab and Tremelimumab | completed | Phase 2 | 21 | Sidney Kimmel Comprehensive Cancer Center at Johns HopkinsOTHER | 1 | Aug 17, 2025 | clinicaltrials |
| NCT06620510 | Retrospective Study of Long-Term Survival of "Immuncell-LC" in Patients Undergoing Curative Resection for HCC in Korea | completed | — | 230 | GC Cell CorporationINDUSTRY | 1 | Aug 15, 2025 | clinicaltrials |
| NCT04791176 | Phase II Study of Concurrent Lenvatinib and Radiotherapy for Advanced HCC | completed | Phase 2 | 64 | Cancer Institute and Hospital, Chinese Academy of Medical SciencesOTHER | 1 | Aug 14, 2025 | clinicaltrials |
| NCT02872116 | Efficacy Study of Nivolumab Plus Ipilimumab or Nivolumab Plus Chemotherapy Against Chemotherapy in Stomach Cancer or Stomach/Esophagus Junction Cancer(CheckMate649) | completed | Phase 3 | 2,031 | Bristol-Myers SquibbINDUSTRY | 29 | Aug 7, 2025 | clinicaltrials |
Data updated 23 days agoSource updated Dec 10, 2025source: clinicaltrials