Clinical trial · Observational
Survival Outcomes by Tumor-Node Stage and Recurrence Patterns in Colon Cancer After Radical Surgery
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
Colon cancer is one of the most common cancers worldwide, and even after curative (radical) surgery, some patients develop recurrence or distant metastasis. Understanding how tumor stage and lymph node status at the time of diagnosis influence the risk and patterns of recurrence is important for guiding follow-up and treatment strategies. This study retrospectively evaluates patients with stage I-III colon cancer who underwent radical surgery at Chang Gung Memorial Hospital between 2006 and 2018. A total of 7,259 patients are included from the institutional tumor registry. Patients are categorized into four tumor-node (TN) stage groups: * T1-3 without lymph node involvement * T1-3 with lymph node involvement * T4 without lymph node involvement * T4 with lymph node involvement The study aims to examine recurrence patterns (no recurrence, local recurrence, isolated lung metastasis, isolated liver metastasis, or multiple sites) and overall survival. Statistical analyses planned include Kaplan-Meier survival analysis and marginal structural models to compare outcomes across different TN stages and recurrence types. This study is based on retrospective data and was approved by the Institutional Review Board of Chang Gung Memorial Hospital (IRB No: 202500389B0). No new patient enrollment or interventions will be performed, and patient consent was waived due to the retrospective nature of the study.
Conditions
Conditions (7)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cancer Recurrence | Colon Neoplasm | PROBABILISTIC | 0.70 |
| Colon Adenocarcinoma | Colon Adenocarcinoma | ONTOLOGY_EXACT | 0.98 |
| Colon Cancer | Malignant Colon Neoplasm | CURATED_EXACT | 0.92 |
| Colon Cancer Stage I | Malignant Colon Neoplasm | CURATED_BROADER | 0.78 |
| Colon Cancer Stage II | Malignant Colon Neoplasm | CURATED_BROADER | 0.78 |
| Colon Cancer Stage III | Malignant Colon Neoplasm | CURATED_BROADER | 0.78 |
| Survival Analysis | — | UNRESOLVED | — |
Interventions
Interventions (0)
Data not yet available
Design
Arms and outcomes
Arms (4)
- label
- T1-3N-
- description
- Patients with stage I-III colon adenocarcinoma, T1-3 tumors without lymph node involvement.
- label
- T1-3N+
- description
- Patients with stage I-III colon adenocarcinoma, T1-3 tumors with lymph node involvement.
- label
- T4N-
- description
- Patients with stage I-III colon adenocarcinoma, T4 tumors without lymph node involvement.
- label
- T4N+
- description
- Patients with stage I-III colon adenocarcinoma, T4 tumors with lymph node involvement.
Primary outcomes (2)
- measure
- Recurrence Patterns After Radical Surgery in Stage I-III Colon Cancer
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with histologically confirmed colon adenocarcinoma * Stage I-III disease at diagnosis * Underwent curative (radical) resection at Chang Gung Memorial Hospital between 2006 and 2018 * Availability of complete clinical, pathological, and follow-up data Exclusion Criteria: * Stage IV colon cancer at initial diagnosis * Non-adenocarcinoma histology (e.g., undifferentiated carcinoma, squamous cell carcinoma, lymphoma, sarcoma) * History of other malignancies or synchronous multiple cancers * Patients who underwent only palliative surgery or local excision * Incomplete medical records or missing follow-up information
References
Publications (0)
Data not yet available