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Clinical trials
52 studies whose conditions map to this entity or one of its descendants. Status and phase are as posted on ClinicalTrials.gov. 50 studies per page.
| NCT | Title | Status | Phase | Enrollment (n) | Sponsor | Countries | Last update | Source |
|---|---|---|---|---|---|---|---|---|
| NCT07170644 | A Study of Nirogacestat in Japanese Adults With Desmoid Tumors/Aggressive Fibromatosis (DT/AF) | active not recruiting | Phase 2 | 20 | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, GermanyINDUSTRY | 1 | Sep 15, 2026 | clinicaltrials |
| NCT07176689 | Nirogacestat in Premenopausal Females With Desmoid Tumor/Aggressive Fibromatosis (DT/AF) | recruiting | Phase 4 | 50 | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, GermanyINDUSTRY |
| 6 |
| Sep 14, 2026 |
| clinicaltrials |
| NCT05949099 | Study of Cryoablation and Nirogacestat for Desmoid Tumor | recruiting | Phase 2 | 28 | Nam BuiOTHER | 1 | Sep 10, 2026 | clinicaltrials |
| NCT02402244 | Project: Every Child for Younger Patients With Cancer | recruiting | — | 75,000 | Children's Oncology GroupNETWORK | 6 | Aug 25, 2026 | clinicaltrials |
| NCT04851119 | Tegavivint for the Treatment of Recurrent or Refractory Solid Tumors, Including Lymphomas and Desmoid Tumors | recruiting | Phase 1 / Phase 2 | 147 | Children's Oncology GroupNETWORK | 1 | Aug 25, 2026 | clinicaltrials |
| NCT03785964 | Nirogacestat for Adults With Desmoid Tumor/Aggressive Fibromatosis (DT/AF)(DeFi) | completed | Phase 3 | 142 | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, GermanyINDUSTRY | 7 | Aug 20, 2026 | clinicaltrials |
| NCT07755176 | Patient-reported Outcomes Following Percutaneous Ablation of Desmoid Tumors | enrolling by invitation | — | 30 | Mayo ClinicOTHER | 1 | Aug 10, 2026 | clinicaltrials |
| NCT04195399 | A Study of a New Drug, Nirogacestat, for Treating Desmoid Tumors That Cannot be Removed by Surgery | active not recruiting | Phase 2 | 31 | Children's Oncology GroupNETWORK | 5 | Jul 30, 2026 | clinicaltrials |
| NCT02066181 | Sorafenib Tosylate in Treating Patients With Desmoid Tumors or Aggressive Fibromatosis | completed | Phase 3 | 87 | National Cancer Institute (NCI)NIH | 2 | Jun 24, 2026 | clinicaltrials |
| NCT02834013 | Nivolumab and Ipilimumab in Treating Patients With Rare Tumors | active not recruiting | Phase 2 | 798 | National Cancer Institute (NCI)NIH | 2 | Jun 17, 2026 | clinicaltrials |
| NCT04871282 | A Study of AL102 in Patients With Progressing Desmoid Tumors(RINGSIDE) | active not recruiting | Phase 2 / Phase 3 | 198 | Immunome, Inc.INDUSTRY | 11 | Jun 8, 2026 | clinicaltrials |
| NCT04281381 | Observing People With Desmoid-Type Fibromatosis | recruiting | — | 100 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | May 15, 2026 | clinicaltrials |
| NCT06660121 | Electrochemotherapy for Desmoid Tumors(ECT-DESMO) | withdrawn | — | 0 | Istituto Ortopedico RizzoliOTHER | 1 | May 14, 2026 | clinicaltrials |
| NCT05041036 | Individual Patient Compassionate Use of Nirogacestat | available | — | — | SpringWorks Therapeutics, Inc., a healthcare company of Merck KGaA, Darmstadt, GermanyINDUSTRY | 0 | May 8, 2026 | clinicaltrials |
| NCT07541430 | A Study in Adults With Desmoid Tumors | recruiting | Phase 2 | 50 | Elpiscience (Suzhou) Biopharma, Ltd.INDUSTRY | 1 | Apr 30, 2026 | clinicaltrials |
| NCT02867033 | National Clinical-biological Prospective Cohort of Incident Cases of Aggressive Fibromatosis (ALTITUDES)(ALTITUDES) | active not recruiting | N/A | 628 | Centre Oscar LambretOTHER | 1 | Mar 30, 2026 | clinicaltrials |
| NCT07496242 | Immunological Phenotype of Desmoid-fibromatosis-affected Patients. | recruiting | — | 200 | Fondazione IRCCS Istituto Nazionale dei Tumori, MilanoOTHER | 2 | Mar 27, 2026 | clinicaltrials |
| NCT07461246 | Familial Adenomatous Poliposys Italian Network (Rete Italiana Poliposi Adenomatosa Familiare)(RIPAF) | active not recruiting | — | 1,500 | Fondazione IRCCS Istituto Nazionale dei Tumori, MilanoOTHER | 1 | Mar 10, 2026 | clinicaltrials |
| NCT05111964 | HIFU Ablation of Soft Tissue Sarcoma(SarcAblate) | recruiting | N/A | 10 | Oxford University Hospitals NHS TrustOTHER | 1 | Feb 4, 2026 | clinicaltrials |
| NCT02476305 | Evaluation of the Cryodestruction of Non Abdominopelvic Desmoid Tumors in Patients Progressing Despite Medical Treatment(CRYODESMO01) | completed | N/A | 50 | University Hospital, Strasbourg, FranceOTHER | 1 | Jan 20, 2026 | clinicaltrials |
| NCT06081400 | Cryoablation Versus Medical Therapy in Desmoid Tumors Progressing After Watchful Waiting(CRYODESMO-02) | recruiting | N/A | 150 | University Hospital, Strasbourg, FranceOTHER | 1 | Nov 19, 2025 | clinicaltrials |
| NCT06945887 | Treatment of Desmoid Fibromatosis With Arterial Embolization(TAE-DESMO) | recruiting | — | 20 | Istituto Ortopedico RizzoliOTHER | 1 | Sep 12, 2025 | clinicaltrials |
| NCT02547831 | Tailored Beta-catenin Mutational Approach in Extra-abdominal Sporadic Desmoids Tumor Patients | completed | — | 100 | Fondazione IRCCS Istituto Nazionale dei Tumori, MilanoOTHER | 1 | Sep 11, 2025 | clinicaltrials |
| NCT06258421 | Burden of Disease and Living Situation in Desmoid Patients(PROSa Desmoid) | completed | — | 100 | Technische Universität DresdenOTHER | 1 | Aug 24, 2025 | clinicaltrials |
| NCT02228889 | RCT of Two Noncrosslinked Porcine Acellular Dermal Matrices in Ab Wall Reconstruction | completed | N/A | 46 | Jeffrey JanisOTHER | 1 | Jun 6, 2025 | clinicaltrials |
| NCT03190174 | Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers | completed | Phase 1 / Phase 2 | 34 | Sarcoma Oncology Research Center, LLCOTHER | 1 | Feb 17, 2025 | clinicaltrials |
| NCT02076906 | MR-guided High Intensity Focused Ultrasound (HIFU) on Pediatric Solid Tumors | completed | Phase 1 | 7 | AeRang KimOTHER | 1 | Jan 1, 2025 | clinicaltrials |
| NCT03802084 | A Study to Evaluate the Safety and Efficacy of Vactosertib and Imatinib in Patients With Advanced Desmoid Tumor | completed | Phase 1 / Phase 2 | 24 | Hyo Song KimOTHER | 1 | May 13, 2024 | clinicaltrials |
| NCT06355921 | A Prospective Clinical Study on the Safety and Efficacy of Radiofrequency Ablation for the Treatment of Patients With Desmoid Tumors(RFAdesmoid) | not yet recruiting | N/A | 27 | Blokhin's Russian Cancer Research CenterOTHER | 1 | Apr 10, 2024 | clinicaltrials |
| NCT01981551 | Phase II Trial of the Gamma-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors/Aggressive Fibromatosis | completed | Phase 2 | 17 | National Cancer Institute (NCI)NIH | 1 | Feb 6, 2024 | clinicaltrials |
| NCT06195085 | CT-guided Radioactive Iodine-125 Seed Implantation for Recurrent Desmoid Tumors | completed | — | 38 | Peking University Third HospitalOTHER | 1 | Jan 8, 2024 | clinicaltrials |
| NCT06113094 | Cryoablation for Advanced and Refractory Desmoid Tumors(CARDT) | unknown | — | 30 | University Hospital, Strasbourg, FranceOTHER | 1 | Nov 2, 2023 | clinicaltrials |
| NCT00928525 | Imatinib in Patients With Desmoid Tumor and Chondrosarcoma(Basket 1) | completed | Phase 2 | 35 | Italian Sarcoma GroupNETWORK | 1 | Oct 5, 2023 | clinicaltrials |
| NCT00919269 | Collecting and Storing Tissue, Blood, and Bone Marrow Samples From Patients With Rhabdomyosarcoma or Other Soft Tissue Sarcoma | completed | — | 150 | Children's Oncology GroupNETWORK | 7 | Oct 3, 2023 | clinicaltrials |
| NCT04289077 | Quality of Life of Patients With Desmoid-type Fibromatosis(QUALIFIED) | completed | — | 156 | Erasmus Medical CenterOTHER | 2 | Sep 7, 2023 | clinicaltrials |
| NCT01265030 | A Pilot Study Evaluating the Use of mTor Inhibitor Sirolimus in Children and Young Adults With Desmoid-Type Fibromatosis | completed | Phase 1 / Phase 2 | 9 | MaineHealthOTHER | 1 | Jun 26, 2023 | clinicaltrials |
| NCT03459469 | Phase I, Open-label, Non-randomized Study to Evaluate Safety of BC2059 | completed | Phase 1 | 24 | Iterion TherapeuticsINDUSTRY | 2 | Mar 1, 2023 | clinicaltrials |
| NCT05561036 | A Randomized, Double-blind,Phase Ⅲ Study of Liposome Doxorubicin in Desmoid Tumor | unknown | Phase 3 | 72 | Sun Yat-sen UniversityOTHER | 1 | Sep 30, 2022 | clinicaltrials |
| NCT03966742 | Doxorubicin Eluting Intra-arterial Embolization for Aggressive Desmoid Fibromatosis | completed | Phase 2 | 8 | Rabin Medical CenterOTHER | 1 | Mar 25, 2022 | clinicaltrials |
| NCT00068419 | Sulindac and Tamoxifen in Treating Patients With Desmoid Tumor | completed | Phase 2 | 70 | Children's Oncology GroupNETWORK | 1 | Feb 19, 2020 | clinicaltrials |
| NCT02374931 | 18F-FES PET/CT in Imaging Patients With Desmoid Tumors | terminated | Early Phase 1 | 3 | Vanderbilt-Ingram Cancer CenterOTHER | 1 | Oct 3, 2019 | clinicaltrials |
| NCT02955446 | Compassionate Use Protocol for PF-03084014 in Patients With Advanced Solid Tumor Malignancies | no longer available | — | — | University of Colorado, DenverOTHER | 1 | Feb 1, 2019 | clinicaltrials |
| NCT01137916 | Study to Evaluate Imatinib in Desmoid Tumors | completed | Phase 2 | 39 | Heidelberg UniversityOTHER | 1 | May 3, 2017 | clinicaltrials |
| NCT00978146 | Effect of Hydroxyurea as Treatment for Primary Desmoid Tumors | withdrawn | Phase 2 | 0 | Children's Hospital of PhiladelphiaOTHER | 0 | Apr 20, 2017 | clinicaltrials |
| NCT00287846 | Imatinib Mesylate in Treating Patients With Recurrent or Refractory Fibromatosis | completed | Phase 1 / Phase 2 | 40 | UNICANCEROTHER | 1 | Aug 30, 2016 | clinicaltrials |
| NCT01567046 | Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas | completed | — | 70 | Children's Oncology GroupNETWORK | 1 | May 17, 2016 | clinicaltrials |
| NCT00474994 | Sunitinib in Treating Patients With Metastatic, Locally Advanced, or Locally Recurrent Sarcomas | completed | Phase 2 | 53 | Memorial Sloan Kettering Cancer CenterOTHER | 1 | Jan 20, 2016 | clinicaltrials |
| NCT02353429 | Toremifene in Desmoid Tumor: Prospective Clinical Trial and Identification of Potential Molecular Targets | unknown | Phase 2 | 25 | Fondazione IRCCS Istituto Nazionale dei Tumori, MilanoOTHER | 1 | Feb 2, 2015 | clinicaltrials |
| NCT00003019 | Vinblastine and Methotrexate in Treating Children With Desmoid Tumors | completed | Phase 2 | 28 | Children's Oncology GroupNETWORK | 3 | Jul 25, 2014 | clinicaltrials |
| NCT00030680 | Radiation Therapy in Treating Patients With Aggressive Fibromatoses | completed | Phase 2 | 44 | European Organisation for Research and Treatment of Cancer - EORTCNETWORK | 7 | Aug 27, 2013 | clinicaltrials |
Data updated 14 days agoSource updated Sep 15, 2026source: clinicaltrials