Subtype
Clear Cell Tumor with Melanocytic Differentiation and MITF-CREM Translocation
CI-CAN-00002385CCTMMCExplore in graph →
Non-malignant
- NCIt
- C204741
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Subtype
CI-CAN-00002385CCTMMCExplore in graph →
Data completeness0 / 7 dimensions
Computed from entity_counters.completeness · refreshed after each connector run
Definition
A MITF pathway-activated melanocytic tumor characterized by a cytogenetic translocation between MITF and CREM genes that results in MITF-CREM gene fusion. It presents as a single non-pigmented cutaneous nodule in the distal extremities. It is composed of large cells with clear cytoplasm that exhibit melanocytic differentiation and proliferate in the dermis without an intraepidermal component. Extension in the subcutaneous tissue is frequently seen. The neoplastic cells exhibit atypical features, including nuclear enlargement and hyperchromasia, irregular nuclear borders, and enlarged nucleolus. Mitotic activity is prominent. The biologic potential of this tumor is unknown.
Data updated 22 days agoSource updated 26.08e
Taxonomy
Several hierarchies coexist; edges are listed per hierarchy type with their source.
Parents
Children (0)
Leaf node — no children.
Anatomy
Data updated 10 hours agoSource updated unknowncounters aggregate over descendants
Names
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Key figures
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No registry-level ancestor: burden figures are published for the mutually exclusive top-level site groups only, and this entity does not descend from one. Global figures (IARC / GLOBOCAN) stay under license review and SEER awaits credentials.
Data updated 10 hours agoSource updated unknownregistry figures: none · counters aggregate over descendants