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Childhood Neoplasm — Research · CancerIndex

Cancers
Neoplasm
Neoplasm by Special Category
Childhood Neoplasm

Cancer Family

Childhood Neoplasm

CI-CAN-00000009Explore in graph →

PediatricNon-malignant312 active trials1 approved drugs68 evidence items

NCIt: C6283

Overview
Statistics
Survival
Genomics1
Variants & evidence68
Drugs16
Trials1503
Research
Rankings
Sources & provenance

Research activity

PubMed record counts

Each count is the number of PubMed records returned by the exact query shown, at the time it was run. Counts are research-activity signals, not quality measures.

Data not yet available

No PubMed query has been run for this entity. Counts require a MeSH-anchored query built from the entity's terminology mappings; the query string is stored with each count so it can be reproduced.

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Trials tab
Methodology: publication counts

Literature

Linked publications (43)

Publications linked to this entity or its descendants, newest first, 25 per page. Link method and validation status are shown; 'candidate' links have not been reviewed.

pubmedProvenance

Source: PubMed (NLM)
Dataset: PubMed E-utilities
Retrieved: Sep 8, 2026
Layer: normalized (units and labels harmonized; values unchanged)

PublishedShowing 1–25 of 43 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

The type II RAF inhibitor tovorafenib in relapsed/refractory pediatric low-grade glioma: the phase 2 FIREFLY-1 trial.
· Nat Med · 2024 · PMID 37978284 · validated civic_curation pubmed
Larotrectinib for paediatric solid tumours harbouring NTRK gene fusions: phase 1 results from a multicentre, open-label, phase 1/2 study.
· Lancet Oncol · 2018 · PMID 29606586 · validated civic_curation pubmed
A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.
· Nat Genet · 1998 · PMID 9462753 · validated civic_curation pubmed
Recurrent internal tandem duplications of BCOR in clear cell sarcoma of the kidney.
· Nat Commun · 2015 · PMID 26573325 · validated civic_curation pubmed
Pediatric low-grade gliomas can be molecularly stratified for risk.
· Acta Neuropathol · 2018 · PMID 29948154 · validated civic_curation pubmed
BRAF-KIAA1549 fusion predicts better clinical outcome in pediatric low-grade astrocytoma.
· Clin Cancer Res · 2011 · PMID 21610142 · validated civic_curation pubmed
Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas.
· Nat Genet · 2013 · PMID 23583981 · validated civic_curation pubmed
Relapse-specific mutations in NT5C2 in childhood acute lymphoblastic leukemia.

Showing 1–25 of 43 publications

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· Nat Genet · 2013 · PMID 23377183 · validated civic_curation pubmed

Wnt/Wingless pathway activation and chromosome 6 loss characterize a distinct molecular sub-group of medulloblastomas associated with a favorable prognosis.

· Cell Cycle · 2006 · PMID 17172831 · validated civic_curation pubmed

Molecular Classification of Ependymal Tumors across All CNS Compartments, Histopathological Grades, and Age Groups.

· Cancer Cell · 2015 · PMID 25965575 · validated civic_curation pubmed

Consistent in-frame internal tandem duplications of BCOR characterize clear cell sarcoma of the kidney.

· Nat Genet · 2015 · PMID 26098867 · validated civic_curation pubmed

Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.

· Nat Genet · 2017 · PMID 28112737 · validated civic_curation pubmed

Childhood supratentorial ependymomas with YAP1-MAMLD1 fusion: an entity with characteristic clinical, radiological, cytogenetic and histopathological features.

· Brain Pathol · 2019 · PMID 30246434 · validated civic_curation pubmed

Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG).

· Neuro Oncol · 2022 · PMID 35395680 · validated civic_curation pubmed

Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.

· Nat Genet · 2001 · PMID 11431691 · validated civic_curation pubmed

Heterogeneous cytogenetic subgroups and outcomes in childhood acute megakaryoblastic leukemia: a retrospective international study.

· Blood · 2015 · PMID 26215111 · validated civic_curation pubmed

Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.

· Lancet Oncol · 2019 · PMID 31151904 · validated civic_curation pubmed

Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics.

· J Pathol · 2009 · PMID 19197950 · validated civic_curation pubmed

ETV6-NTRK3 in congenital mesoblastic nephroma: A report of the SIOP/GPOH nephroblastoma study.

· Pediatr Blood Cancer · 2018 · PMID 29286563 · validated civic_curation pubmed

Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors.

· Am J Surg Pathol · 2000 · PMID 10895816 · validated civic_curation pubmed

Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues.

· Am J Clin Pathol · 2001 · PMID 11242790 · validated civic_curation pubmed

Congenital mesoblastic nephroma: a study of 19 cases using immunohistochemistry and ETV6-NTRK3 fusion gene rearrangement.

· Pathology · 2016 · PMID 27020209 · validated civic_curation pubmed

Whole transcriptome sequencing identifies BCOR internal tandem duplication as a common feature of clear cell sarcoma of the kidney.

· Oncotarget · 2015 · PMID 26516930 · validated civic_curation pubmed

Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney.

· J Pathol · 2012 · PMID 22294382 · validated civic_curation pubmed

Congenital mesoblastic nephroma is characterised by kinase mutations including EGFR internal tandem duplications, the ETV6-NTRK3 fusion, and the rare KLHL7-BRAF fusion.

· Histopathology · 2020 · PMID 32590884 · validated civic_curation pubmed