Publication
A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerInfantile Fibrosarcomacivic_curation1.00
- geneNTRK3civic_curation1.00
- variantNTRK3 Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 9462753
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| NTRK3 Fusion2 | ||||||||
| (diagnostic) | Infantile FibrosarcomaALIAS | Diagnostic | A | Supports Positive | 4 | accepted | EID8332This is the first study showing the ETV6-NTRK3 gene fusion in congenital fibrosarcoma (CFS). Using cytogenetic and FISH analyses, a novel t(12;15)(p13;q25) rearrangement was identified in CFS cases (3… (full text at CIViC) PMID 9462753 · Knezevich et al., 1998 · Open in CIViC | civic |
| (oncogenic) | Infantile FibrosarcomaALIAS | Oncogenic | C | Supports Oncogenicity | 3 | accepted | EID10502A novel and recurrent t(12;15)(p13;q25) translocation was identified in all three cases of congenital fibrosarcoma (CFS) studied. Molecular cloning of the breakpoints revealed that this translocation … (full text at CIViC) PMID 9462753 · Knezevich et al., 1998 · Open in CIViC | civic |
| NTRK3 R248C1 | ||||||||
| (diagnostic) | Infantile FibrosarcomaALIAS | Diagnostic | A | Supports Positive | 4 | rejected | EID8331This is the first study showing the ETV6-NTRK3 gene fusion in congenital fibrosarcoma (CFS). Using cytogenetic and FISH analyses, a novel t(12;15)(p13;q25) rearrangement was identified in CFS cases (3… (full text at CIViC) PMID 9462753 · Knezevich et al., 1998 · Open in CIViC | civic |