Publication
Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerAcute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1civic_curation1.00
- geneGLIS2civic_curation1.00
- geneMRTFAcivic_curation1.00
- variantGLIS2 Fusioncivic_curation1.00
- variantMRTFA Fusioncivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 28112737
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| MRTFA Fusion1 | ||||||||
| (diagnostic) | Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1ALIAS | Diagnostic | B | Supports Positive | 4 | accepted | EID12261In this study, the authors explored the genomic landscape of acute megakaryoblastic leukemia (AMKL) in patients without Down syndrome (non-DS-AMKL). AMKL is a rare and heterogeneous subtype of acute m… (full text at CIViC) PMID 28112737 · de Rooij et al., 2017 · Open in CIViC | civic |
| GLIS2 Fusion1 | ||||||||
| (diagnostic) | Acute Myeloid Leukemia With CBFA2T3::GLIS2 FusionUNRESOLVED | Diagnostic | B | Supports Positive | 4 | accepted | EID11886In this 2017 study the authors included 74 pediatric patients diagnosed with non-down syndrome acute megakaryoblastic leukemia (AMKL). RNASeq was performed on 62 patients, where sufficient RNA was ava… (full text at CIViC) PMID 28112737 · de Rooij et al., 2017 · Open in CIViC | civic |