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Central Nervous System Neoplasm — Research · CancerIndex

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Neoplasm
Neoplasm by Site
Nervous System Neoplasm
Central Nervous System Neoplasm

Cancer Family

Central Nervous System Neoplasm

CI-CAN-00000118Explore in graph →

Non-malignant1,345 active trials7 approved drugs177 evidence items

NCIt: C9293
MeSH: D016543

Overview
Statistics
Survival
Genomics36
Variants & evidence177
Drugs37
Trials5058
Research
Rankings
Sources & provenance

Research activity

PubMed record counts

Each count is the number of PubMed records returned by the exact query shown, at the time it was run. Counts are research-activity signals, not quality measures.

Data not yet available

No PubMed query has been run for this entity. Counts require a MeSH-anchored query built from the entity's terminology mappings; the query string is stored with each count so it can be reproduced.

What CancerIndex knows

Trials tab
Methodology: publication counts

Literature

Linked publications (138)

Publications linked to this entity or its descendants, newest first, 25 per page. Link method and validation status are shown; 'candidate' links have not been reviewed.

pubmedProvenance

Source: PubMed (NLM)
Dataset: PubMed E-utilities
Retrieved: Sep 8, 2026
Layer: normalized (units and labels harmonized; values unchanged)

PublishedShowing 51–75 of 138 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

Genomic analysis of diffuse intrinsic pontine gliomas identifies three molecular subgroups and recurrent activating ACVR1 mutations.
· Nat Genet · 2014 · PMID 24705254 · validated civic_curation pubmed
Polymorphisms of CDKN1A gene and risk of retinoblastoma.
· Carcinogenesis · 2013 · PMID 24045412 · validated civic_curation pubmed
Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial.
· Lancet Oncol · 2019 · PMID 31151904 · validated civic_curation pubmed
Beta-catenin status in paediatric medulloblastomas: correlation of immunohistochemical expression with mutational status, genetic profiles, and clinical characteristics.
· J Pathol · 2009 · PMID 19197950 · validated civic_curation pubmed
Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma.
· Oncotarget · 2012 · PMID 23104868 · validated civic_curation pubmed
Recurrent activating ACVR1 mutations in diffuse intrinsic pontine glioma.
· Nat Genet · 2014 · PMID 24705252 · validated civic_curation pubmed
A single-arm phase II Austrian/German multicenter trial on continuous daily sunitinib in primary glioblastoma at first recurrence (SURGE 01-07).
· Neuro Oncol · 2014 · PMID 24311637 · validated

Showing 51–75 of 138 publications

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civic_curation

Histone H3F3A and HIST1H3B K27M mutations define two subgroups of diffuse intrinsic pontine gliomas with different prognosis and phenotypes.

· Acta Neuropathol · 2015 · PMID 26399631 · validated civic_curation pubmed

High-grade neuroepithelial tumor with BCOR exon 15 internal tandem duplication-a comprehensive clinical, radiographic, pathologic, and genomic analysis.

· Brain Pathol · 2020 · PMID 31104347 · validated civic_curation pubmed

C11orf95-RELA fusions drive oncogenic NF-κB signalling in ependymoma.

· Nature · 2014 · PMID 24553141 · validated civic_curation pubmed

A multi-institutional retrospective pooled outcome analysis of molecularly annotated pediatric supratentorial ZFTA-fused ependymoma.

· Neurooncol Adv · 2023 · PMID 37287693 · validated civic_curation pubmed

Molecular grouping and outcomes of young children with newly diagnosed ependymoma treated on the multi-institutional SJYC07 trial.

· Neuro Oncol · 2019 · PMID 30976811 · validated civic_curation pubmed

Supratentorial ependymomas of childhood carry C11orf95-RELA fusions leading to pathological activation of the NF-κB signaling pathway.

· Acta Neuropathol · 2014 · PMID 24562983 · validated civic_curation pubmed

CNS high-grade neuroepithelial tumor with BCOR internal tandem duplication: a comparison with its counterparts in the kidney and soft tissue.

· Brain Pathol · 2018 · PMID 29226988 · validated civic_curation pubmed

Genetic alterations in uncommon low-grade neuroepithelial tumors: BRAF, FGFR1, and MYB mutations occur at high frequency and align with morphology.

· Acta Neuropathol · 2016 · PMID 26810070 · validated civic_curation pubmed

Phase I study of vemurafenib in children with recurrent or progressive BRAFV600E mutant brain tumors: Pacific Pediatric Neuro-Oncology Consortium study (PNOC-002).

· Oncotarget · 2020 · PMID 32523649 · validated civic_curation pubmed

MN1 rearrangement in astroblastoma: study of eight cases and review of literature.

· Brain Tumor Pathol · 2019 · PMID 31111274 · validated civic_curation pubmed

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog-Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032.

· J Clin Oncol · 2015 · PMID 26169613 · validated civic_curation pubmed

Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.

· Oncotarget · 2016 · PMID 26894859 · validated civic_curation pubmed

Correlation between IDH1 gene mutation status and survival of patients treated for recurrent glioma.

· Anticancer Res · 2011 · PMID 22199315 · validated civic_curation pubmed

Progressive low-grade oligodendrogliomas: response to temozolomide and correlation between genetic profile and O6-methylguanine DNA methyltransferase protein expression.

· Cancer · 2006 · PMID 16541434 · validated civic_curation pubmed

Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma.

· Science · 2013 · PMID 23539183 · validated civic_curation pubmed

Phase I trial of lapatinib in children with refractory CNS malignancies: a Pediatric Brain Tumor Consortium study.

· J Clin Oncol · 2010 · PMID 20713864 · validated civic_curation pubmed

Immune Checkpoint Inhibition for Hypermutant Glioblastoma Multiforme Resulting From Germline Biallelic Mismatch Repair Deficiency.

· J Clin Oncol · 2016 · PMID 27001570 · validated civic_curation pubmed

Durable Response to Larotrectinib in a Child With Histologic Diagnosis of Recurrent Disseminated Ependymoma Discovered to Harbor an NTRK2 Fusion: The Impact of Integrated Genomic Profiling.

· JCO Precis Oncol · 2021 · PMID 34651095 · validated civic_curation pubmed