Publication
Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
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Linked entities
Linked entities (3)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 3
- cancerAnaplastic Astrocytomacivic_curation1.00
- geneATRXcivic_curation1.00
- variantATRX Mutationcivic_curation1.00
Curated evidence
Evidence citing this paper (3)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 23104868
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| ATRX Mutation3 | ||||||||
| (diagnostic) | Anaplastic AstrocytomaALIAS | Diagnostic | B | Supports Positive | 3 | accepted | EID8868Whole exome sequencing of 4 low grade gliomas (LGGs) and targeted sequencing of 28 LGGs revealed ATRX variants are found exclusively in a subset of IDH1-mutant, 1p/19q intact LGGs. Paired blood sample… (full text at CIViC) PMID 23104868 · Kannan et al., 2012 · Open in CIViC | civic |
| 〃 | Brain GliomaUNRESOLVED | Diagnostic | B | Supports Positive | 3 | rejected | EID8866The study examined 4 cases of low grade glioma (LGG) with whole exome sequencing, followed by targeted sequencing of 28 LGGs. The study demonstrated that all IDH-mutant LGG with intact 1p/19q status h… (full text at CIViC) PMID 23104868 · Kannan et al., 2012 · Open in CIViC | civic |
| 〃 | Brain GliomaUNRESOLVED | Diagnostic | B | Supports Positive | 3 | rejected | EID8867The study examined 4 cases of low grade glioma (LGG) with whole exome sequencing, followed by targeted sequencing of 28 LGGs. The study demonstrated that all IDH-mutant LGG with intact 1p/19q status h… (full text at CIViC) PMID 23104868 · Kannan et al., 2012 · Open in CIViC | civic |