Publication
Transcriptomic analysis of aggressive meningiomas identifies PTTG1 and LEPR as prognostic biomarkers independent of WHO grade.
Authors not recorded
- Source
- PubMed
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CIVIC-20260908-000001
Abstract
Abstract (excerpt)
Only the opening of the abstract is shown; abstract text may carry publisher copyright.
Data not yet available
Linked entities
Linked entities (5)
How each link was made (MeSH, dictionary, registry reference, curation…) and whether it has been validated. Candidate links are not counted in entity statistics.
Validated 5
- cancerMeningiomacivic_curation1.00
- geneLEPRcivic_curation1.00
- genePTTG1civic_curation1.00
- variantLEPR UNDEREXPRESSIONcivic_curation1.00
- variantPTTG1 OVEREXPRESSIONcivic_curation1.00
Curated evidence
Evidence citing this paper (2)
- Source
- CIViC — Clinical Interpretation of Variants in Cancer
- Dataset
- CIViC evidence items
- Version
- civic-2026-09-08
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Evidence
- expert curation
- License
- CC0 1.0
- PMID
- 26894859
- Run
- ING-CIVIC-20260908-000001
| Therapy | Cancer | Type | Level | Direction · significance | Rating (1–5) | Status | Evidence | Source |
|---|---|---|---|---|---|---|---|---|
| LEPR UNDEREXPRESSION1 | ||||||||
| (prognostic) | Meningioma | Prognostic | B | Supports Poor Outcome | 2 | accepted | EID1054144 cases (discovery set: N=62 discovery; Independent validation set: N = 82) of meningiomas were analyzed for transcriptional features defining aggressive clinical course (recurrent, malignantly prog… (full text at CIViC) PMID 26894859 · Schmidt et al., 2016 · Open in CIViC | civic |
| PTTG1 OVEREXPRESSION1 | ||||||||
| (prognostic) | Meningioma | Prognostic | B | Supports Poor Outcome | 2 | accepted | EID1053144 cases (discovery set: N=62 discovery; independent validation set: N = 82) of meningiomas were analyzed for transcriptional features defining aggressive clinical course (recurrent, malignantly prog… (full text at CIViC) PMID 26894859 · Schmidt et al., 2016 · Open in CIViC | civic |