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Central Nervous System Neoplasm — Research · CancerIndex

Cancers
Neoplasm
Neoplasm by Site
Nervous System Neoplasm
Central Nervous System Neoplasm

Cancer Family

Central Nervous System Neoplasm

CI-CAN-00000118Explore in graph →

Non-malignant1,345 active trials7 approved drugs177 evidence items

NCIt: C9293
MeSH: D016543

Overview
Statistics
Survival
Genomics36
Variants & evidence177
Drugs37
Trials5058
Research
Rankings
Sources & provenance

Research activity

PubMed record counts

Each count is the number of PubMed records returned by the exact query shown, at the time it was run. Counts are research-activity signals, not quality measures.

Data not yet available

No PubMed query has been run for this entity. Counts require a MeSH-anchored query built from the entity's terminology mappings; the query string is stored with each count so it can be reproduced.

What CancerIndex knows

Trials tab
Methodology: publication counts

Literature

Linked publications (138)

Publications linked to this entity or its descendants, newest first, 25 per page. Link method and validation status are shown; 'candidate' links have not been reviewed.

pubmedProvenance

Source: PubMed (NLM)
Dataset: PubMed E-utilities
Retrieved: Sep 8, 2026
Layer: normalized (units and labels harmonized; values unchanged)

PublishedShowing 76–100 of 138 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

A Unique Case Report of Infant-Type Hemispheric Glioma (Gliosarcoma Subtype) with TPR-NTRK1 Fusion Treated with Larotrectinib.
· Pathobiology · 2022 · PMID 35034013 · validated civic_curation pubmed
Cribriform neuroepithelial tumor: molecular characterization of a SMARCB1-deficient non-rhabdoid tumor with favorable long-term outcome.
· Brain Pathol · 2017 · PMID 27380723 · validated civic_curation pubmed
Smoothened mutation confers resistance to a Hedgehog pathway inhibitor in medulloblastoma.
· Science · 2009 · PMID 19726788 · validated civic_curation pubmed
Rapid radiographic and clinical improvement after treatment of a MET-amplified recurrent glioblastoma with a mesenchymal-epithelial transition inhibitor.
· J Clin Oncol · 2012 · PMID 22162573 · validated civic_curation pubmed
Immunogenomics of Hypermutated Glioblastoma: A Patient with Germline POLE Deficiency Treated with Checkpoint Blockade Immunotherapy.
· Cancer Discov · 2016 · PMID 27683556 · validated civic_curation pubmed
Response of recurrent BRAFV600E mutated ganglioglioma to Vemurafenib as single agent.
· J Transl Med · 2014 · PMID 25524464 · validated civic_curation pubmed
Treatment of Pediatric Glioblastoma with Combination Olaparib and Temozolomide Demonstrates 2-Year Durable Response.
· Oncologist · 2020 · PMID 32043779 · validated

Showing 76–100 of 138 publications

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civic_curation

Clinical response to dabrafenib plus trametinib in a pediatric ganglioglioma with BRAF p.T599dup mutation.

· Cold Spring Harb Mol Case Stud · 2021 · PMID 33637608 · validated civic_curation pubmed

Activity of Pemigatinib in Pilocytic Astrocytoma and FGFR1N546K Mutation.

· JCO Precis Oncol · 2022 · PMID 35507888 · validated civic_curation pubmed

Mosaicism for Receptor Tyrosine Kinase Activation in a Glioblastoma Involving Both PDGFRA Amplification and NTRK2 Fusion.

· Oncologist · 2021 · PMID 34041811 · validated civic_curation pubmed

Refractory infantile high-grade glioma containing TRK-fusion responds to larotrectinib.

· Pediatr Blood Cancer · 2021 · PMID 33403813 · validated civic_curation pubmed

Cribriform neuroepithelial tumor (CRINET): a nonrhabdoid ventricular tumor with INI1 loss and relatively favorable prognosis.

· J Neuropathol Exp Neurol · 2009 · PMID 19915490 · validated civic_curation pubmed

High-Resolution Genomic Analysis of Cribriform Neuroepithelial Tumors of the Central Nervous System.

· J Neuropathol Exp Neurol · 2015 · PMID 26352987 · validated civic_curation pubmed

Phase II Study of Erdafitinib in Patients With Tumors With Fibroblast Growth Factor Receptor Mutations or Fusions: Results From the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol K2.

· JCO Precis Oncol · 2024 · PMID 38603650 · validated civic_curation pubmed

Afatinib, an irreversible ErbB family blocker, with protracted temozolomide in recurrent glioblastoma: a case report.

· Oncotarget · 2015 · PMID 26423602 · validated civic_curation pubmed

PTEN gene mutations are seen in high-grade but not in low-grade gliomas.

· Cancer Res · 1997 · PMID 9331072 · validated civic_curation pubmed

Spinal ependymomas in neurofibromatosis Type 2: a retrospective analysis of 55 patients.

· J Neurosurg Spine · 2011 · PMID 21294614 · validated civic_curation pubmed

CDKN2A/B Loss Is Associated with Anaplastic Transformation in a Case of NTRK2 Fusion-positive Pilocytic Astrocytoma.

· Neuropathol Appl Neurobiol · 2019 · PMID 29804288 · validated civic_curation pubmed

Supratentorial non-RELA, ZFTA-fused ependymomas: a comprehensive phenotype genotype correlation highlighting the number of zinc fingers in ZFTA-NCOA1/2 fusions.

· Acta Neuropathol Commun · 2021 · PMID 34389065 · validated civic_curation pubmed

MYB upregulation and genetic aberrations in a subset of pediatric low-grade gliomas.

· Acta Neuropathol · 2010 · PMID 21046410 · validated civic_curation pubmed

NTRK fusion detection across multiple assays and 33,997 cases: diagnostic implications and pitfalls.

· Mod Pathol · 2020 · PMID 31375766 · validated civic_curation pubmed

Polymorphous Low-Grade Neuroepithelial Tumor of the Young (PLNTY): Molecular Profiling Confirms Frequent MAPK Pathway Activation.

· J Neuropathol Exp Neurol · 2021 · PMID 34363682 · validated civic_curation pubmed

Supratentorial ependymoma with YAP1:FAM118B fusion: A case report.

· Neuropathology · 2021 · PMID 33480048 · validated civic_curation pubmed

Entrectinib demonstrates prolonged efficacy in an adult case of radiation-refractory NTRK fusion glioblastoma.

· Neurooncol Adv · 2022 · PMID 35673607 · validated civic_curation pubmed

An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells.

· Science · 2013 · PMID 23558169 · validated civic_curation pubmed