Hematologic Malignancy
B-Cell Non-Hodgkin Lymphoma
CI-CAN-00000471Explore in graph →
Hematologic1,757 active trials43 approved drugs73 evidence items
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Hematologic Malignancy
CI-CAN-00000471Explore in graph →
Genomics
25 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
537 cases with simple somatic mutation data · 537 cases total · 2026-01-06 · mapped to Small Lymphocytic Lymphoma EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | SF3B1 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| Ssm |
| 113 |
| 537 |
| 21% |
| cbioportal |
| 2 | ATM | Ssm | 82 | 537 | 15.3% | cbioportal |
| 3 | TP53 | Ssm | 39 | 537 | 7.3% | cbioportal |
| 4 | NOTCH1 | Ssm | 38 | 537 | 7.1% | cbioportal |
| 5 | POT1 | Ssm | 35 | 537 | 6.5% | cbioportal |
| 6 | PCLO | Ssm | 28 | 537 | 5.2% | cbioportal |
| 7 | CHD2 | Ssm | 26 | 537 | 4.8% | cbioportal |
| 8 | XPO1 | Ssm | 24 | 537 | 4.5% | cbioportal |
| 9 | RPS15 | Ssm | 22 | 537 | 4.1% | cbioportal |
| 11 | TTN | Ssm | 21 | 537 | 3.9% | cbioportal |
| 10 | MUC16 | Ssm | 21 | 537 | 3.9% | cbioportal |
| 12 | BRAF | Ssm | 20 | 537 | 3.7% | cbioportal |
| 14 | CSMD3 | Ssm | 19 | 537 | 3.5% | cbioportal |
| 13 | BIRC3 | Ssm | 19 | 537 | 3.5% | cbioportal |
| 16 | MGA | Ssm | 17 | 537 | 3.2% | cbioportal |
| 15 | EGR2 | Ssm | 17 | 537 | 3.2% | cbioportal |
| 18 | MYD88 | Ssm | 16 | 537 | 3% | cbioportal |
| 17 | LRP1B | Ssm | 16 | 537 | 3% | cbioportal |
| 19 | FAT4 | Ssm | 15 | 537 | 2.8% | cbioportal |
| 20 | USH2A | Ssm | 15 | 537 | 2.8% | cbioportal |
| 22 | KRAS | Ssm | 14 | 537 | 2.6% | cbioportal |
| 21 | FAT3 | Ssm | 14 | 537 | 2.6% | cbioportal |
| 23 | DDX3X | Ssm | 13 | 537 | 2.4% | cbioportal |
| 24 | PCDH15 | Ssm | 13 | 537 | 2.4% | cbioportal |
| 26 | CSMD1 | Ssm | 12 | 537 | 2.2% | cbioportal |
| 25 | BCOR | Ssm | 12 | 537 | 2.2% | cbioportal |
| 28 | IGLL5 | Ssm | 12 | 537 | 2.2% | cbioportal |
| 27 | FBXW7 | Ssm | 12 | 537 | 2.2% | cbioportal |
| 30 | IKZF3 | Ssm | 11 | 537 | 2% | cbioportal |
| 32 | SAMHD1 | Ssm | 11 | 537 | 2% | cbioportal |
Data updated 22 days agoSource updated 2026-01-06