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Astrocytic Tumor — Research · CancerIndex

Cancers
Neoplasm
Neoplasm by Morphology
Neuroepithelial, Perineurial, and Schwann Cell Neoplasm
Neuroepithelial Neoplasm
Glioma
Astrocytic Tumor

Subtype

Astrocytic Tumor

CI-CAN-00001839Explore in graph →

Non-malignant507 active trials2 approved drugs67 evidence items

NCIt: C6958
MeSH: D001254

Overview
Statistics
Survival
Genomics2
Variants & evidence67
Drugs26
Trials1861
Research
Rankings
Sources & provenance

Research activity

PubMed record counts

Each count is the number of PubMed records returned by the exact query shown, at the time it was run. Counts are research-activity signals, not quality measures.

Data not yet available

No PubMed query has been run for this entity. Counts require a MeSH-anchored query built from the entity's terminology mappings; the query string is stored with each count so it can be reproduced.

What CancerIndex knows

Trials tab
Methodology: publication counts

Literature

Linked publications (50)

Publications linked to this entity or its descendants, newest first, 25 per page. Link method and validation status are shown; 'candidate' links have not been reviewed.

pubmedProvenance

Source: PubMed (NLM)
Dataset: PubMed E-utilities
Retrieved: Sep 8, 2026
Layer: normalized (units and labels harmonized; values unchanged)

PublishedShowing 1–25 of 50 publications · bibliographic data as recorded by PubMed; abstracts are not reproduced.

MGMT gene silencing and benefit from temozolomide in glioblastoma.
· N Engl J Med · 2005 · PMID 15758010 · validated civic_curation pubmed
IDH1 and IDH2 mutations in gliomas.
· N Engl J Med · 2009 · PMID 19228619 · validated civic_curation pubmed
Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma.
· Nat Genet · 2013 · PMID 23817572 · validated civic_curation pubmed
Inactivation of the DNA-repair gene MGMT and the clinical response of gliomas to alkylating agents.
· N Engl J Med · 2000 · PMID 11070098 · validated civic_curation pubmed
TERT promoter mutations in primary and secondary glioblastomas.
· Acta Neuropathol · 2013 · PMID 23955565 · validated civic_curation pubmed
Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors.
· N Engl J Med · 2005 · PMID 16282176 · validated civic_curation pubmed
LRP1B deletion is associated with poor outcome for glioblastoma patients.
· J Neurol Sci · 2015 · PMID 26428308 · validated civic_curation pubmed
Tandem duplication producing a novel oncogenic BRAF fusion gene defines the majority of pilocytic astrocytomas.

Showing 1–25 of 50 publications

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· Cancer Res · 2008 · PMID 18974108 · validated civic_curation pubmed

A single-center study of the clinicopathologic correlates of gliomas with a MYB or MYBL1 alteration.

· Acta Neuropathol · 2019 · PMID 31595312 · validated civic_curation pubmed

Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course.

· Acta Neuropathol · 2020 · PMID 31563982 · validated civic_curation pubmed

Genomic analysis of diffuse pediatric low-grade gliomas identifies recurrent oncogenic truncating rearrangements in the transcription factor MYBL1.

· Proc Natl Acad Sci U S A · 2013 · PMID 23633565 · validated civic_curation pubmed

Entrectinib in children and young adults with solid or primary CNS tumors harboring NTRK, ROS1, or ALK aberrations (STARTRK-NG).

· Neuro Oncol · 2022 · PMID 35395680 · validated civic_curation pubmed

Loss of PTEN is not associated with poor survival in newly diagnosed glioblastoma patients of the temozolomide era.

· PLoS One · 2012 · PMID 22479427 · validated civic_curation pubmed

IDH1 mutations in low-grade astrocytomas predict survival but not response to temozolomide.

· Neurology · 2009 · PMID 19933982 · validated civic_curation pubmed

The prognostic IDH1( R132 ) mutation is associated with reduced NADP+-dependent IDH activity in glioblastoma.

· Acta Neuropathol · 2010 · PMID 20127344 · validated civic_curation pubmed

Prognostic value of epidermal growth factor receptor in patients with glioblastoma multiforme.

· Cancer Res · 2003 · PMID 14583498 · validated civic_curation pubmed

The MGMT promoter SNP rs16906252 is a risk factor for MGMT methylation in glioblastoma and is predictive of response to temozolomide.

· Neuro Oncol · 2015 · PMID 25910840 · validated civic_curation pubmed

A phase II, multicenter trial of rindopepimut (CDX-110) in newly diagnosed glioblastoma: the ACT III study.

· Neuro Oncol · 2015 · PMID 25586468 · validated civic_curation pubmed

ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis.

· Acta Neuropathol · 2013 · PMID 23904111 · validated civic_curation pubmed

Correlation between O6-methylguanine-DNA methyltransferase and survival in inoperable newly diagnosed glioblastoma patients treated with neoadjuvant temozolomide.

· J Clin Oncol · 2007 · PMID 17442989 · validated civic_curation pubmed

O6-methylguanine DNA methyltransferase expression in tumor cells predicts outcome of radiotherapy plus concomitant and adjuvant temozolomide therapy in patients with primary glioblastoma.

· Brain Tumor Pathol · 2011 · PMID 21331613 · validated civic_curation pubmed

Recurrent somatic mutations in ACVR1 in pediatric midline high-grade astrocytoma.

· Nat Genet · 2014 · PMID 24705250 · validated civic_curation pubmed

Somatic histone H3 alterations in pediatric diffuse intrinsic pontine gliomas and non-brainstem glioblastomas.

· Nat Genet · 2012 · PMID 22286216 · validated civic_curation pubmed

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal.

· Proc Natl Acad Sci U S A · 2013 · PMID 23530248 · validated civic_curation pubmed

Whole-exome sequencing identifies ATRX mutation as a key molecular determinant in lower-grade glioma.

· Oncotarget · 2012 · PMID 23104868 · validated civic_curation pubmed