Acute Myeloid Leukemia with NPM1-MLF1 — Variants & evidence

Acute Myeloid Leukemia with NPM1-MLF1 — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

3 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–3 of 3 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MLF1 Fusion3
(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12130 In this 2010 study the authors included 5876 acute myeloid leukemia cases. The median age of the patients was 44 years (range 16 to 59 years). With cytogenetic analysis the t(3;5)(q21∼25;q31∼35) (like… (full text at CIViC) PMID 20385793 · Grimwade et al., 2010 · Open in CIViC	civic
〃	Diagnostic	C	Supports Positive	4	accepted	EID12129 In this 2024 study the authors analyzed RNA sequencing data from 887 pediatric acute myeloid leukemia (AML) cases. The median age of the cohort was 9.3 years (range 0 to 24 years). Oncogenic driver fu… (full text at CIViC) PMID 38212634 · Umeda et al., 2024 · Open in CIViC	civic
〃	Diagnostic	C	Supports Positive	3	accepted	EID12128 In this 2019 study the authors aimed to detect the driver genetic alterations in a cohort of Japanese pediatric AML patients. Gene fusions were detected in 53/139 patients with RNA sequencing. The NPM… (full text at CIViC) PMID 31648321 · Shiba et al., 2019 · Open in CIViC	civic

Data updated 14 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.