MLF1 Fusion

CI-VAR-00001425Explore in graph →CIViC 5011

Curated evidence

Evidence by cancer (3 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–3 of 3 evidence items across 1 cancer context on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Myeloid Leukemia with NPM1-MLF13
NPM1::MLF1 Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12130 In this 2010 study the authors included 5876 acute myeloid leukemia cases. The median age of the patients was 44 years (range 16 to 59 years). With cytogenetic analysis the t(3;5)(q21∼25;q31∼35) (like… (full text at CIViC) PMID 20385793 · Grimwade et al., 2010 · Open in CIViC	civic
NPM1::MLF1 Fusion	(diagnostic)	Diagnostic	C	Supports Positive	3	accepted	EID12128 In this 2019 study the authors aimed to detect the driver genetic alterations in a cohort of Japanese pediatric AML patients. Gene fusions were detected in 53/139 patients with RNA sequencing. The NPM… (full text at CIViC) PMID 31648321 · Shiba et al., 2019 · Open in CIViC	civic

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.