Acute Myeloid Leukemia with Genetic Abnormalities

In this study, researchers examined the diagnostic significance of the PML::RARA fusion in acute promyelocytic leukemia (APL, FAB-M3), a subtype of acute myeloid leukemia (AML) associated with the t(1… (full text at CIViC)

PMID 38304177 · Santana-Hernández et al., 2024 · Open in CIViC

This study presents a rare case of acute promyelocytic leukemia (APL) characterized by an atypical PML::RARA fusion transcript resulting from the t(15;17) translocation. The patient, a 44-year-old fem… (full text at CIViC)

PMID 17934255 · Ismail et al., 2007 · Open in CIViC

In this study, the authors investigated the molecular characteristics of acute promyelocytic leukemia (APL) in patients with atypical PML::RARA fusion transcripts. APL is a rare and aggressive leukemi… (full text at CIViC)

PMID 30421475 · Iaccarino et al., 2019 · Open in CIViC

ATRA/Arsenic combined with standard chemotherapy has been shown to induce a complete remission rate of greater than 75% of patients with acute promyelocytic leukemia harboring the PML-RARa fusion.

PMID 11704842 · Degos et al., 2001 · Open in CIViC

Gemtuzumab ozogamicin (GO) was used in a study to treat 16 patients in various stages of molecular relapsed APL. GO was administered at 6 mg/m2 for 2 doses and RT-PCR was subsequently performed for PM… (full text at CIViC)

PMID 15187030 · Lo-Coco et al., 2004 · Open in CIViC

Fusion protein degradation is accelerated upon ATRA treatment of acute promyelocytic cells at pharmalogical concentrations.

PMID 8674046 · Yoshida et al., 1996 · Open in CIViC

A 39-year old woman who presented with acute myeloid leukemia revealed a complicated genetic profile using conventional metaphase cytogenetics and FISH analysis. Whole genome sequencing elucidated a … (full text at CIViC)

PMID 21505136 · Welch et al., 2011 · Open in CIViC

ive point mutations were identified in the PML B2 domain of PML-RARA transcripts in 9 patients diagnosed with APL and resistant to arsenic. DNA from these patients was amplified using polymerase chain… (full text at CIViC)

PMID 26537301 · Liu et al., 2016 · Open in CIViC

Five point mutations were identified in the PML B2 domain of PML-RARA transcripts in 9 patients diagnosed with APL and resistant to arsenic. DNA from these 9 patients was cloned into flag-tagged pCag … (full text at CIViC)

PMID 26537301 · Liu et al., 2016 · Open in CIViC

The mutation A216V in the B2 domain of PML in the PML-RARa fusion was seen in a patient with ATRA-resistant acute promyelocytic leukemia.

PMID 21613260 · Goto et al., 2011 · Open in CIViC

The PML L218P mutation in the PML-RARa fusion was observed in a patient with previously ATRA-treated, relapsed acute promyelocytic leukemia refractory to arsenic trioxide.

PMID 21613260 · Goto et al., 2011 · Open in CIViC

Five point mutations were identified in the PML B2 domain of PML-RARA transcripts in 9 patients diagnosed with APL and resistant to arsenic. DNA from these 9 patients was cloned into flag-tagged pCag … (full text at CIViC)

PMID 26537301 · Liu et al., 2016 · Open in CIViC

The authors report a case of a 6-year-old child with leukemia and the clinical and morphologic characteristics of acute promyelocytic leukemia (APL), but without evidence of the expected t(15;17) or a… (full text at CIViC)

PMID 34432867 · Astolfi et al., 2021 · Open in CIViC

The authors report a TTMV-RARA (viral fusion) in a 39-year-old patient with leukemia and blasts that were APL-like with increased promyelocytes. The fusion was identified by targeted long read sequenc… (full text at CIViC)

PMID 35420676 · Sala-Torra et al., 2022 · Open in CIViC

This study evaluated the independent prognostic significance of pretreatment cytogenetics based on the large Medical Research Council (MRC) AML 10 trial which enrolled a total of 1,966 patients (364 c… (full text at CIViC)

PMID 9746770 · Grimwade et al., 1998 · Open in CIViC

This study evaluated the independent prognostic significance of pretreatment cytogenetics based on the large Medical Research Council (MRC) AML 10 trial which enrolled a total of 1,966 patients (364 c… (full text at CIViC)

PMID 9746770 · Grimwade et al., 1998 · Open in CIViC