Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1

Acute Myeloid Leukemia (Megakaryoblastic) with t(1;22)(p13.3;q13.1); RBM15-MKL1 — Variants & evidence · CancerIndex

Variants & evidence

Curated clinical evidence by variant and therapy

4 evidence items mapped to this entity or its descendants, grouped by molecular profile, then therapy. 50 items per page.

civicCuratedShowing 1–4 of 4 evidence items · levels, directions and significance as curated at the source; each row links to its CIViC record.

Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
MRTFA Fusion4
(diagnostic)	Diagnostic	A	Supports Positive	5	submitted	EID8513 AML (megakaryoblastic) with t(1;22)(p13.3;q13.3);RBM15-MKL1, is a defined diagnostic subgroup in the 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukem… (full text at CIViC) PMID 27069254 · Arber et al., 2016 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12260 In this study, the authors investigated the association of the RBM15::MRTFA fusion with acute megakaryoblastic leukemia (AMKL, FAB-M7), particularly in non-Down syndrome infants and young children. A… (full text at CIViC) PMID 11431691 · Ma et al., 2001 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12261 In this study, the authors explored the genomic landscape of acute megakaryoblastic leukemia (AMKL) in patients without Down syndrome (non-DS-AMKL). AMKL is a rare and heterogeneous subtype of acute m… (full text at CIViC) PMID 28112737 · de Rooij et al., 2017 · Open in CIViC	civic
〃	Diagnostic	B	Supports Positive	4	accepted	EID12262 In this study, the authors performed an international retrospective analysis of 490 pediatric patients (≤18 years) with non–Down syndrome acute megakaryoblastic leukemia (non-DS-AMKL), a rare and aggr… (full text at CIViC) PMID 26215111 · Inaba et al., 2015 · Open in CIViC	civic

Data updated 18 hours agoSource updated unknownsource: civic (CC0)

Evidence levels, directions and ratings are those assigned by CIViC curators. "Submitted" items have not completed curation review. This is not treatment guidance.