Hematologic Malignancy
Acute Leukemia
CI-CAN-00000399Explore in graph →
Hematologic1,259 active trials30 approved drugs323 evidence items
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Hematologic Malignancy
CI-CAN-00000399Explore in graph →
Genomics
17 cohorts mapped to this entity or its descendants. Each frequency is affected / profiled within one cohort; cohorts are shown separately because case selection, sequencing depth and definitions differ. By default the cohort with the most cases profiled is shown.
72 cases with simple somatic mutation data · 200 cases total · 2026-01-13 · mapped to Acute Myeloid Leukemia EXACT_IDENTIFIER
| # | Gene | Alteration | Affected (n) | Profiled (n) | Frequency (%) | Source |
|---|---|---|---|---|---|---|
| 1 | NPM1 | Ssm | 8 |
Cohorts mapped to a descendant (e.g. a subtype) are included because their cases belong to this entity by definition; the mapping and its match type are shown per cohort.
| 72 |
| 11.1% |
| cbioportal |
| 2 | DNMT3A | Ssm | 5 | 72 | 6.9% | cbioportal |
| 3 | IDH2 | Ssm | 5 | 72 | 6.9% | cbioportal |
| 4 | TP53 | Ssm | 5 | 72 | 6.9% | cbioportal |
| 5 | RUNX1 | Ssm | 4 | 72 | 5.6% | cbioportal |
| 10 | TTN | Ssm | 3 | 72 | 4.2% | cbioportal |
| 7 | ELF4 | Ssm | 3 | 72 | 4.2% | cbioportal |
| 8 | FLT3 | Ssm | 3 | 72 | 4.2% | cbioportal |
| 9 | KRAS | Ssm | 3 | 72 | 4.2% | cbioportal |
| 6 | ASXL1 | Ssm | 3 | 72 | 4.2% | cbioportal |
| 12 | BCORL1 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 14 | CALR | Ssm | 2 | 72 | 2.8% | cbioportal |
| 18 | ITPR3 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 19 | KIT | Ssm | 2 | 72 | 2.8% | cbioportal |
| 16 | CUL1 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 20 | NF1 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 13 | BSN | Ssm | 2 | 72 | 2.8% | cbioportal |
| 21 | NR2E1 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 22 | PHF6 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 23 | PTPN11 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 15 | CEBPA | Ssm | 2 | 72 | 2.8% | cbioportal |
| 24 | SCAF8 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 25 | STRIP2 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 11 | ASXL3 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 17 | DNAH11 | Ssm | 2 | 72 | 2.8% | cbioportal |
| 51 | ATP2C1 | Ssm | 1 | 72 | 1.4% | cbioportal |
| 52 | ATP6V1B1 | Ssm | 1 | 72 | 1.4% | cbioportal |
| 53 | ATP6V1C1 | Ssm | 1 | 72 | 1.4% | cbioportal |
| 54 | ATRNL1 | Ssm | 1 | 72 | 1.4% | cbioportal |
| 55 | AURKC | Ssm | 1 | 72 | 1.4% | cbioportal |
Data updated 22 days agoSource updated 2026-01-13