KMT2A Fusion

CI-VAR-00001266Explore in graph →CIViC 2806

Curated evidence

Evidence by cancer (8 items)

Grouped by cancer context first, then therapy. The same variant can be sensitizing in one cancer and irrelevant in another — contexts are never merged. 50 items per page; a cancer group may continue on the next page.

civicCuratedShowing 1–8 of 8 evidence items across 3 cancer contexts on this page · levels, directions and significance as curated at the source; each row links to its CIViC record.

Molecular profile	Therapy	Type	Level	Direction · significance	Rating (1–5)	Status	Evidence	Source
Acute Biphenotypic Leukemia1
KMT2A::v Fusion	EPZ004777	Predictive	D	Supports Sensitivity Response	4	submitted	EID7582 KMT2A (MLL) gene encodes a transcriptional co-activator harboring a SET domain with H3K4 histone methyl transferase activity which mediates chromatin modifications associated with epigenetic transcrip… (full text at CIViC) PMID 21741596 · Daigle et al., 2011 · Open in CIViC	civic
Acute Myeloid Leukemia with KMT2A Rearrangement4
KMT2A::v Fusion	(diagnostic)	Diagnostic	A	Supports Positive	4	accepted	EID1029 In this publication, the 2008 revision of the World Health Organization (WHO) classification of myeloid neoplasms and acute leukemia is discussed. The MLL-MLLT3 translocation, along with other MLL tra… (full text at CIViC)

ClinVar

Clinical significance (0)

ClinVar interpretations are shown as structured records — significance, review status, star rating, conditions — never flattened into one word.

Data not yet available

No ClinVar interpretation attached to this variant.

B Lymphoblastic Leukemia/Lymphoma with t(v;11q23.3); KMT2A Rearranged3
KMT2A::v Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12473 In this study, the authors used long-distance inverse PCR and sequencing to comprehensively analyze KMT2A (MLL) gene rearrangements in 2,345 acute leukemia patients, including those with B-lymphoblast… (full text at CIViC) PMID 28701730 · Meyer et al., 2018 · Open in CIViC	civic
KMT2A::v Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12474 In this publication, the authors conducted a comprehensive genomic analysis of 2,754 pediatric acute lymphoblastic leukemia (ALL) cases using integrated whole genome, exome, and transcriptome sequenci… (full text at CIViC) PMID 36050548 · Brady et al., 2022 · Open in CIViC	civic
KMT2A::v Fusion	(diagnostic)	Diagnostic	B	Supports Positive	4	accepted	EID12475 In this publication, the diagnostic significance of KMT2A rearrangements in B-lymphoblastic leukemia/lymphoma (B-ALL) is explored. The study reveals that KMT2A fusions are not restricted to lymphoid l… (full text at CIViC) PMID 38686611 · Aypar et al., 2024 · Open in CIViC	civic