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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,122 stopped studies mapped to Non-Small Cell Carcinoma and descendants · 90% state a reason
Over the 1,122 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00090675 | Maintenance ZD1839 (IRESSA®) Following Completion of Front Line, Platinum-Based, Double…(IMAC/Herbst) | Phase 3 | withdrawn | Sep 3, 2004 | AstraZeneca | No patients randomised | Other (stated, no rule matched) |
| NCT00040768 | Bortezomib in Treating Patients With Advanced Non-small Cell Lung Cancer | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00862134 | Randomized, Multi-center, Open-label, Study of PR104 Versus PR104/Docetaxel in Non-Small… | Phase 2 | terminated | Mar 16, 2009 | Proacta, Incorporated | Interim analysis indicated low probability of clinically significant result | Efficacy / futility |
| NCT01071434 | Feasibility of Using Real-time Cine-MRI for Treating Moving & Deforming Tumors | — | terminated | Feb 19, 2010 | Stanford University | PI left | Investigator |
| NCT01004510 | Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer(ZAP) | Phase 2 | terminated | Oct 30, 2009 | Peter Bushunow MD | failure to accrue projected number of patients | Enrollment / accrual |
| NCT01124812 | 131I-L19SIP Radioimmunotherapy Combined With Radiochemotherapy in Patients With… | Phase 1 | terminated | May 17, 2010 | Philogen S.p.A. | not stated | Not stated |
| NCT00694603 | Cetuximab as Therapy for Recurrent Non-Small Cell Lung Cancer Patients Who Have Received… | Phase 2 | terminated | Jun 10, 2008 | Lecia V. Sequist | Slow accrual | Enrollment / accrual |
| NCT00093132 | Satraplatin for Locally Advanced Non-Small Cell Lung Cancer With Simultaneous Radiotherapy | Phase 1 / Phase 2 | terminated | Oct 4, 2004 | Agennix | Sponsor decided to discontinue study drug development. | Sponsor / business decision |
| NCT00386555 | A Phase 2 Study in Patients With Advanced Non-Small Cell Lung Cancer Using New Agents… | Phase 2 | withdrawn | Oct 11, 2006 | Arog Pharmaceuticals, Inc. | Study was cancelled before patient enrollment | Enrollment / accrual |
| NCT00048087 | Iressa/Docetaxel in Non-Small-Cell Lung Cancer | Phase 2 | withdrawn | Oct 25, 2002 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT01373463 | Cisplatin and Pemetrexed With Radiation Followed by Lobectomy(CisPemXetSrg) | Phase 1 | terminated | Jun 15, 2011 | Medical University of South Carolina | Investigator left site | Investigator |
| NCT01314677 | Fludeoxyglucose F 18 PET/CT Scans in Predicting Therapy Response in Patients With Stage… | N/A | withdrawn | Mar 14, 2011 | City of Hope Medical Center | No subjects have been accrued to this trial. The PI will no longer be at COH and requests a study… | Enrollment / accrual |
| NCT00522938 | Clinical Trial of the Safety and Effectiveness of CHR-2797 With Erlotinib in Patients… | Phase 1 / Phase 2 | terminated | Aug 30, 2007 | Chroma Therapeutics | Very poor recruitment of patients to the study | Enrollment / accrual |
| NCT00442026 | Randomized Trial of Docetaxel and Gemcitabine Versus Gemcitabine in Elderly Patients With… | Phase 3 | terminated | Mar 1, 2007 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00971191 | A Study In Patients Who Will Undergo Surgical Removal Of Non-Small Cell Lung Cancer To… | Phase 1 | terminated | Sep 3, 2009 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT00042302 | A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Phase III Study of… | Phase 3 | terminated | Aug 1, 2002 | QLT Inc. | not stated | Not stated |
| NCT00042315 | A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Phase III Study of… | Phase 3 | terminated | Aug 1, 2002 | QLT Inc. | not stated | Not stated |
| NCT00291850 | Phase II Trial of Dose-dense Paclitaxel and Cisplatin as Neo-adjuvant Chemotherapy for… | Phase 2 | terminated | Feb 15, 2006 | Central European Cooperative Oncology Group | no patient recruitment | Enrollment / accrual |
| NCT01052766 | Breathing Synchronized PET/CT Scans for the Detection of Malignant Lung & Liver Lesions… | N/A | terminated | Jan 20, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01063400 | Feasibility Study: Comparison of Performance Status With Objective Physical Activity… | — | terminated | Feb 5, 2010 | University of Wisconsin, Madison | lack of funding | Funding |
| NCT00460551 | Zalutumumab in Combination With Chemo-Radiation in a Certain Type of Lung Cancer | Phase 2 | terminated | Apr 16, 2007 | Genmab | Due to considerations regarding the appropriate therapeutic regimen for these patients. | Other (stated, no rule matched) |
| NCT01449357 | Zalutumumab in Non-Small Cell Lung Cancer (NSCLC) Patients Refractory to Tyrosine Kinase… | Phase 2 | withdrawn | Oct 10, 2011 | Genmab | Trial never initiated | Other (stated, no rule matched) |
| NCT00437749 | A Study of CBT-1 and Paclitaxel With Carboplatin in Patients With Advanced Inoperable… | Phase 3 | terminated | Feb 21, 2007 | CBA Research | slow accrual rate; interim accrual objective met | Enrollment / accrual |
| NCT00830245 | A Study to Assess the Efficacy of Erlotinib for Leptomeningeal Carcinomatosis in EGFR… | Phase 2 | terminated | Jan 27, 2009 | Clinical Research Center for Solid Tumor, Korea | low accrual rate | Enrollment / accrual |
| NCT00970645 | Study Comparing EBUS & EUS to Mediastinoscopy in Staging and Detection of Lung Cancer | N/A | terminated | Sep 2, 2009 | Mayo Clinic | Similar study published results | Other (stated, no rule matched) |
| NCT00369447 | A Study of Nimotuzumab in Combination With External Radiotherapy in Non-Small Cell Lung… | Phase 1 / Phase 2 | terminated | Aug 29, 2006 | YM BioSciences | The study was closed due to slow accrual. | Enrollment / accrual |
| NCT00872482 | A Study of Nimotuzumab in Combination With Radiation Therapy in Patients With Brain… | Phase 2 | terminated | Mar 31, 2009 | YM BioSciences | Study closed due to low enrollment | Enrollment / accrual |
| NCT00539331 | Phase I/II Study of AZD2171 in Combination With Paclitaxel/Carboplatin in Japanese… | Phase 1 | terminated | Oct 4, 2007 | AstraZeneca | not stated | Not stated |
| NCT00343187 | A Phase II Study of ACZONE™ (Dapsone) Gel, 5% As a Treatment For Tarceva®… | Phase 2 | terminated | Jun 22, 2006 | Allergan | Lack of enrollment | Enrollment / accrual |
| NCT00234468 | Iressa vs Placebo as Maintenance Therapy in Locally Advanced NSCLC | Phase 3 | terminated | Oct 7, 2005 | AstraZeneca | Closed due to insufficient recruitment | Enrollment / accrual |
| NCT00232206 | Trial of Neoadjuvant Docetaxel and Cisplatin for Resectable Non-Small Cell Lung Cancer | Phase 2 | terminated | Oct 4, 2005 | Providence Health & Services | study terminated due to slow accrual | Enrollment / accrual |
| NCT00540280 | Randomized Phase III Trial of Surgery Alone or Surgery Plus Preoperative… | Phase 3 | suspended | Oct 5, 2007 | King Faisal Specialist Hospital & Research Center | Follow up only | Other (stated, no rule matched) |
| NCT00117351 | VELCADE in Previously Treated Patients With Stage IIIB and IV Bronchioloalveolar… | Phase 2 | terminated | Jul 6, 2005 | Millennium Pharmaceuticals, Inc. | insufficient efficacy | Efficacy / futility |
| NCT00283634 | A Study of Tarceva for Use in Patients With Relapsed or Refractory Metastatic Non-Small… | Phase 2 | terminated | Jan 30, 2006 | Millennium Pharmaceuticals, Inc. | insufficient efficacy | Efficacy / futility |
| NCT00354562 | A Phase 2 Study Evaluating ABT-751 in Combination With Taxotere in Advanced Non-Small… | Phase 1 / Phase 2 | terminated | Jul 20, 2006 | Abbott | not stated | Not stated |
| NCT00721981 | An Evaluation of the Clinical Treatment and Patient Values and Preferences of Patients… | — | terminated | Jul 25, 2008 | AstraZeneca | Low Recruitment | Enrollment / accrual |
| NCT00329472 | Efficacy Study of Induction Chemotherapy Before Surgery in Operable Non-small Cell Lung… | Phase 3 | withdrawn | May 24, 2006 | Samsung Medical Center | poor enrollment | Enrollment / accrual |
| NCT00783471 | Docetaxel Intermittent-Erlotinib (Tarceva®) In Metastatic Non Small Cell Lung Cancer…(DOPERLO) | Phase 2 | terminated | Oct 31, 2008 | Hellenic Cooperative Oncology Group | The low accrual rate of the study (30% of the expected accrual rate)/Low efficacy in both treatment… | Efficacy / futility |
| NCT00099879 | Study of BMS-275183 in Patients With Pre-treated Non-small Cell Lung Cancer | Phase 2 | terminated | Dec 22, 2004 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00359450 | Study of BMS-275183 in Patients With Pretreated Locally Advanced or Metastatic NSCLC (Non… | Phase 2 | terminated | Aug 2, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00277329 | Study of XL999 in Patients With Non-small Cell Lung Cancer | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subejcts | Safety / toxicity |
| NCT00491699 | Safety Study of XL999 in Adults With Non-Small-Cell Lung Cancer | Phase 1 | terminated | Jun 26, 2007 | Symphony Evolution, Inc. | The study was stopped due to safety concerns | Safety / toxicity |
| NCT01000896 | Study to Assess Safety and Tolerability of AZD0530 in Combination With Carboplatin and… | Phase 1 | withdrawn | Oct 23, 2009 | AstraZeneca | AstraZeneca has discontinued the development of AZD0530. No new AstraZeneca-sponsored clinical… | Other (stated, no rule matched) |
| NCT00473486 | Study in Patients With Advanced Non-Small Cell Lung Cancer Treated With Pemetrexed and…(PECASO) | Phase 1 / Phase 2 | terminated | May 15, 2007 | University Hospital Muenster | Sorafenib administered in the combination with pemetrexed-carboplatin appears to enhance… | Other (stated, no rule matched) |
| NCT00378573 | Multicenter Evaluation of Docetaxel, Gemcitabine, and Bevacizumab Combination Followed by… | Phase 2 | terminated | Sep 20, 2006 | Sanofi | Incidence of GI Perforation | Other (stated, no rule matched) |
| NCT00264134 | Docetaxel, Irinotecan, and Carboplatin in Extensive Stage Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | terminated | Dec 12, 2005 | Kentuckiana Cancer Institute | not stated | Not stated |
| NCT00271323 | Safety Study of Docetaxel/Cisplatin Induction Therapy Followed by Concurrent… | Phase 2 | terminated | Dec 30, 2005 | Sanofi | not stated | Not stated |
| NCT00313768 | Randomized Ph 2 Trial Of Paclitaxel/Carboplatin /Bevacizumab + PF-3512676 And P/C/B Alone… | Phase 2 | terminated | Apr 12, 2006 | Pfizer | See Termination Reason in Detailed Description. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jan 29, 2013source: clinicaltrials