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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,685 stopped studies mapped to Malignant Thoracic Neoplasm and descendants · 90% state a reason
Over the 1,685 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00006374 | Combination Chemotherapy in Treating Patients With Extensive-Stage Small Cell Lung Cancer | Phase 2 | withdrawn | Jun 9, 2004 | Case Comprehensive Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00858403 | Dasatinib in Advanced Non-small Cell Lung Cancer (NSCL) With Ex Vivo and In Vivo… | Phase 2 | terminated | Mar 9, 2009 | H. Lee Moffitt Cancer Center and Research Institute | Slow Accrual | Enrollment / accrual |
| NCT01637376 | Photodynamic Therapy (PDT) With Temoporfin for Non-Resectable Non-Small-Cell Lung Cancer | Phase 1 | withdrawn | Jul 11, 2012 | University of Arkansas | No participants were enrolled | Enrollment / accrual |
| NCT00596830 | Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced… | Phase 3 | terminated | Jan 17, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01871480 | CIK Cell Transfusion Plus Gefitinib As Second Or Third-Line Treatment for Advanced… | Phase 2 | terminated | Jun 6, 2013 | Kunming Medical University | not stated | Not stated |
| NCT00558636 | A Trial Comparing Safety and Efficacy of Carboplatin and Paclitaxel Plus or Minus… | Phase 3 | terminated | Nov 15, 2007 | Bayer | Terminated early when the results from Study NCT00300885 showed an overall lack of efficacy in… | Efficacy / futility |
| NCT00856427 | Implantation of Markers for the Radiotherapy of Lung Cancer Patients | Phase 1 | terminated | Mar 5, 2009 | Virginia Commonwealth University | Slow accrual | Enrollment / accrual |
| NCT01836341 | Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With… | Phase 1 | withdrawn | Apr 19, 2013 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT00801736 | ERCC1 Targeted Trial(ET) | Phase 3 | terminated | Dec 3, 2008 | University College, London | The antibody used did not appear prognostic/predictive based on interim results. | Other (stated, no rule matched) |
| NCT01533727 | CIK Cell Transfusion Plus Chemotherapy as Adjuvant Therapy for Stage IB-IIIA Non-Small… | Phase 2 | withdrawn | Feb 15, 2012 | Sun Yat-sen University | Few patients would like to participate ,since CIK cell transfusion was a new treatment and its… | Efficacy / futility |
| NCT00887315 | The Synergistic Metastases Annihilation With Radiotherapy and Docetaxel (Taxotere)…(SMART) | Phase 2 | terminated | Apr 23, 2009 | University of Chicago | Slow accrual and loss of sponsor | Enrollment / accrual |
| NCT00701870 | Study of Telintra for Treatment of Chemotherapy Induced Neutropenia in Patients With… | Phase 2 | terminated | Jun 19, 2008 | Telik | Study TLK199.2102 was terminated for lack of enrollment. | Enrollment / accrual |
| NCT01504542 | Immune Response and Safety of HS110 Vaccine in Combination With Erlotinib in Patients… | Phase 2 | withdrawn | Jan 5, 2012 | Heat Biologics | Lack of enrollment | Enrollment / accrual |
| NCT00004159 | Gemcitabine Plus Paclitaxel in Treating Patients With Advanced Non-small Cell Lung Cancer… | Phase 1 / Phase 2 | terminated | Jul 26, 2004 | University of Alabama at Birmingham | not stated | Not stated |
| NCT00365183 | Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in… | Phase 2 | terminated | Aug 17, 2006 | Pharmacyclics LLC. | not stated | Not stated |
| NCT01060514 | Pazopanib + Vinorelbine in Non Small Cell Lung Cancer (NSCLC) and Breast Cancer | Phase 1 | terminated | Feb 2, 2010 | Northwestern University | Lack of timely accrual. | Enrollment / accrual |
| NCT01674738 | TS Stratified Chemotherapy and VEGF Inhibition in Non-Squamous Non-Small Cell Lung Cancer…(SELECT-A) | Phase 2 | withdrawn | Aug 29, 2012 | Aktion Bronchialkarzinom e.V. | Decision of the Sponsor, as the funding of the study was no longer guaranteed. | Funding |
| NCT00578084 | Lung Cancer Location: a Repository | — | terminated | Dec 20, 2007 | Indiana University | not stated | Not stated |
| NCT00536107 | Study to Assess Safety/Tolerability/Efficacy of Gefitinib Versus Docetaxel in Locally… | Phase 4 | terminated | Sep 27, 2007 | AstraZeneca | not stated | Not stated |
| NCT00003847 | VX-710, Doxorubicin, and Vincristine for the Treatment of Patients With Recurrent Small… | Phase 2 | terminated | Jun 16, 2004 | Vertex Pharmaceuticals Incorporated | not stated | Not stated |
| NCT00385398 | QOL-Stereotactic RadioSurgery, Temozolomide + Erlotinib-Rx of 1-3 Brain Metastases in… | Phase 2 | withdrawn | Oct 9, 2006 | University of Medicine and Dentistry of New Jersey | lack of funding and drug supply | Drug supply |
| NCT01210131 | Hypoxia-guided Radiotherapy With Cisplatin-etoposide in Stage I-III : Small Cell Lung…(HX4 in SCLC) | N/A | withdrawn | Sep 28, 2010 | Maastricht Radiation Oncology | not stated | Not stated |
| NCT00406276 | Phase I/II Trial of RAD001 Plus Docetaxel in Patients With Metastatic or Recurrent… | Phase 1 / Phase 2 | terminated | Dec 4, 2006 | Emory University | data analysis showed insufficient drug efficacy | Efficacy / futility |
| NCT01010334 | Comparison of Standard of Care or Treatment on Protocol | N/A | terminated | Nov 10, 2009 | New Mexico Cancer Research Alliance | PI deparature and very low (\<2%) accrual rate.(No results required) | Enrollment / accrual |
| NCT01026025 | Duet TRS Used in Pulmonary Resections | N/A | withdrawn | Dec 4, 2009 | Medtronic - MITG | Sponsor is no longer pursuing this study | Other (stated, no rule matched) |
| NCT00017537 | Vaccine Therapy in Treating Patients With Metastatic or Recurrent Cancer | Phase 1 | withdrawn | Jan 8, 2004 | University of Alabama at Birmingham | not stated | Not stated |
| NCT01728181 | A Phase I/II Study of Tivozanib and Erlotinib as Initial Treatment for Metastatic… | Phase 1 / Phase 2 | withdrawn | Nov 16, 2012 | University of Utah | Stopped before approval due to ineffective drug | Other (stated, no rule matched) |
| NCT00673049 | Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer(NSCLC) | Phase 3 | terminated | May 7, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01006226 | 64CuATSM and Hypoxia in Stage IV Non-small Cell Lung Cancer With Carboplatin, Paclitaxel,… | N/A | withdrawn | Nov 2, 2009 | Washington University School of Medicine | Withdrawn due to funding issues | Funding |
| NCT00054392 | Combination Chemotherapy in Treating Patients With Stage IIIB, Stage IV, or Recurrent… | Phase 3 | withdrawn | Feb 6, 2003 | Fox Chase Cancer Center | Not opened at Fox Chase Cancer Center | Other (stated, no rule matched) |
| NCT00896467 | Psychological and Emotional Impact in Patients Undergoing Treatment For Metastatic Cancer… | — | terminated | May 11, 2009 | Centre Oscar Lambret | not stated | Not stated |
| NCT01282333 | Veliparib, Cisplatin, and Gemcitabine Hydrochloride in Treating Patients With Advanced… | Phase 1 | terminated | Jan 25, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00113386 | Cisplatin and Docetaxel With or Without Radiation Therapy in Treating Patients Who Are… | Phase 3 | terminated | Jun 8, 2005 | Radiation Therapy Oncology Group | This study terminated early due to low accrual. | Enrollment / accrual |
| NCT01337154 | First Line Study of Tamibarotene in Combination for Advanced Non-Small Cell Lung Cancer | Phase 2 | terminated | Apr 18, 2011 | CytRx | Interim analysis showed that the primary endpoint would not be met. | Efficacy / futility |
| NCT01888692 | To Evaluate the Impact of PET/CT on Radiation Treatment Planning in Relation to Changes… | — | terminated | Jun 28, 2013 | University of Manitoba | Poor accural | Other (stated, no rule matched) |
| NCT00773383 | A Study of the Effect of R1507 in Combination With Tarceva (Erlotinib) on… | Phase 2 | terminated | Oct 16, 2008 | Hoffmann-La Roche | not stated | Not stated |
| NCT00049608 | Gemcitabine Combined With Mistletoe in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Jan 27, 2003 | National Center for Complementary and Integrative Health (NCCIH) | Principal investigator \[PI\] has left institution. | Investigator |
| NCT00087269 | Erlotinib in Treating Patients With Stage I-IIIA Non-Small Cell Lung Cancer Undergoing… | Phase 2 | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01376856 | Characteristics of Mediastinal Lymph Node With False Positive FDG PET/CT Results in Lung… | — | terminated | Jun 20, 2011 | Yonsei University | not stated | Not stated |
| NCT00697476 | Study of Oral Vorinostat in Combination With Topotecan in Patients With Chemosensitive… | Phase 1 / Phase 2 | terminated | Jun 13, 2008 | Armando Santoro, MD | insufficient enrollment | Enrollment / accrual |
| NCT00758134 | Trastuzumab Therapy in Non-Small Cell Lung Cancer Patients | Phase 2 | terminated | Sep 23, 2008 | Armando Santoro, MD | Insufficient accrual | Enrollment / accrual |
| NCT00055887 | Chemotherapy and Radiation Therapy With or Without Efaproxiral in Treating Patients With… | Phase 3 | withdrawn | Mar 7, 2003 | Spectrum Pharmaceuticals, Inc | Study never started. No patients were enrolled. | Enrollment / accrual |
| NCT00916669 | A Randomized Study to Evaluate the Effect of Two Different Doses of Enoxaparin Sodium in… | Phase 2 | withdrawn | Jun 9, 2009 | Massachusetts General Hospital | sponsor withdrew funding prior to patient enrollment | Enrollment / accrual |
| NCT01383408 | Distinction Between Lung Cancer and Gynecological Cancers by Canine Scent Detection | Phase 2 | terminated | Jun 28, 2011 | Schillerhoehe Hospital | Inconsistent training status of sniffer dogs | Other (stated, no rule matched) |
| NCT00268255 | Gefitinib and Radiation Therapy in Treating Patients With Inoperable Stage I or Stage II… | Phase 1 / Phase 2 | withdrawn | Dec 22, 2005 | Barbara Ann Karmanos Cancer Institute | Study never moved forward with accrual. | Enrollment / accrual |
| NCT00818090 | Paclitaxel and Cisplatin for Thymic Neoplasm | Phase 2 | terminated | Jan 7, 2009 | Korean Cancer Study Group | marginal statistical significance | Other (stated, no rule matched) |
| NCT01480141 | A Window of Opportunity Trial of Afatinib In Early Stage Non-Small Cell Lung Cancer… | Phase 2 | withdrawn | Nov 28, 2011 | Medical University of South Carolina | PI left MUSC, no patient enrollments | Investigator |
| NCT01088620 | Panitumumab Plus Pemetrexed and Cisplatin (PemCisP) Versus PemCis in the First-line… | Phase 2 | suspended | Mar 17, 2010 | WiSP Wissenschaftlicher Service Pharma GmbH | the DSMB stopped the trial due to unacceptable side effects in the experimental arm which has not… | Other (stated, no rule matched) |
| NCT00032084 | S0002 - A Program to Quit Smoking With or Without Bupropion in Treating Patients With… | Phase 3 | terminated | Jan 27, 2003 | SWOG Cancer Research Network | This study was closed early due to poor accrual | Enrollment / accrual |
| NCT00937482 | Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases… | Phase 1 | terminated | Jul 13, 2009 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jan 15, 2014source: clinicaltrials