Clinical trial · Interventional
Implantation of Markers for the Radiotherapy of Lung Cancer Patients
NCT00856427CI-TRIAL-00013210terminatedPhase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Slow accrual
Summary
Brief summary (as posted)
This clinical trial studies imaging markers in planning radiation therapy in patients with lung cancer. Implanting markers in the tumor that can be seen using imaging procedures during radiation therapy may allow x-rays to be sent directly to the tumor and cause less damage to normal tissue.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Lung Cancer | Malignant Lung Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| implanted fiducial-based imaging | Procedure | — | UNRESOLVED |
| radiation therapy treatment planning/simulation | Radiation | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- Diagnostic
- description
- Patients undergo implantation of radio-opaque markers into the primary lesion and affected lymph nodes by bronchoscopy. Patients then undergo routine 4D CT, 4D CBCT, fluoroscopy, and x-ray imaging during standard stereotactic radiation therapy (early stage tumors) or conventionally fractionated radiation therapy (advanced stage tumors).
- interventionNames
- Radiation: radiation therapy treatment planning/simulation
- Procedure: implanted fiducial-based imaging
Primary outcomes (6)
- measure
- Number of dropped markers
- timeFrame
- up to 5 years
- measure
- Marker misplacements
- timeFrame
- up to 5 years
- measure
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Diagnosis of non-small cell lung cancer * Stage I-IIIB disease * No prior surgical tumor resection * Respiration-induced tumor motion \> 5 mm * Recruited by attending physician or research nurse at the Medical College of Virginia Hospitals PATIENT CHARACTERISTICS: * Not pregnant * No insufficient lung function or other parameters prohibiting a bronchoscopy * Not a prisoner or institutionalized PRIOR CONCURRENT THERAPY: * See Disease Characteristics * Concurrent chemotherapy allowed
References
Publications (0)
Data not yet available
No reference posted for this study.