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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,672 stopped studies mapped to Malignant Reproductive System Neoplasm and descendants · 89% state a reason
Over the 1,672 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00505661 | Letrozole in Patients With Ovarian Tumors | Phase 2 | terminated | Jul 23, 2007 | M.D. Anderson Cancer Center | Terminated due to slow patient accrual. | Enrollment / accrual |
| NCT00820287 | Identification of Predictive Markers for Testis Cancer in a Population of Men With High… | N/A | terminated | Jan 12, 2009 | Centre Hospitalier Universitaire de Nice | not stated | Not stated |
| NCT00480623 | A Phase I Trial of Satraplatin Plus Radiation Therapy for Prostate Cancer Patients With… | Phase 1 | terminated | May 31, 2007 | Agennix | Sponsor decided to discontinue study drug development | Sponsor / business decision |
| NCT00253461 | 11C Topotecan PET Imaging | Early Phase 1 | terminated | Nov 15, 2005 | Case Comprehensive Cancer Center | Drugs unavailable:unable to make radioactive topotecan | Other (stated, no rule matched) |
| NCT01340599 | Defined Green Tea Catechin Extract in Treating Patients With Localized Prostate Cancer… | Phase 2 | terminated | Apr 22, 2011 | Case Comprehensive Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00773318 | SPECT-CT Guided Lymphatic Mapping and Sentinel Lymphadenectomy (LM/SL) in Prostate Cancer | N/A | terminated | Oct 16, 2008 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1 patient has been enrolled. No complications reported. The research team decided to terminate the… | Enrollment / accrual |
| NCT00989105 | Technetium Tc 99m Demobesin-4 for Imaging Procedures in Patients With Prostate Cancer | Phase 1 | terminated | Oct 2, 2009 | Cancer Research UK | not stated | Not stated |
| NCT01132599 | Comparing PET-CT Using C-11 Choline and 18F-Fluoromethylcholine in Patients With… | Phase 2 | withdrawn | May 28, 2010 | Cancer Research UK | not stated | Not stated |
| NCT01212887 | Treated Blood Cells, Cyclophosphamide, Fludarabine Phosphate, and Aldesleukin in Treating… | Phase 1 | terminated | Oct 1, 2010 | Cancer Research UK | due to safety concerns and lack of efficacy | Safety / toxicity |
| NCT01096381 | Potential Biomarkers for Bevacizumab-Induced High Blood Pressure in Patients With Solid… | — | terminated | Mar 31, 2010 | Vanderbilt-Ingram Cancer Center | funding withdrawn due to fellow's departure from VICC | Funding |
| NCT00585741 | Pilot Study of 18F-FLT PET | N/A | terminated | Jan 3, 2008 | University of Wisconsin, Madison | not stated | Not stated |
| NCT00736164 | Selenomethionine in Treating Patients Undergoing Surgery or Internal Radiation Therapy… | Phase 2 | withdrawn | Aug 15, 2008 | Roswell Park Cancer Institute | No accrual | Enrollment / accrual |
| NCT01132404 | Study in Men With Prostate Cancer to Assess the Safety, Pharmacokinetics and… | Phase 1 / Phase 2 | terminated | May 28, 2010 | Millennium Pharmaceuticals, Inc. | Developing new formulation of study drug. New study to open next year under a new protocol. | Other (stated, no rule matched) |
| NCT01510288 | Phase 1 Trial of Ipilimumab and GVAX in Patients With Metastatic Castration-resistant… | Phase 1 | terminated | Jan 16, 2012 | Amsterdam UMC, location VUmc | The study was terminated because Cell Genesys stopped all activities for GVAX. | Other (stated, no rule matched) |
| NCT00122252 | Biological Imaging for Optimising Clinical Target Volume (CTV) and Gross Tumour Volume… | — | terminated | Jul 22, 2005 | Alberta Health services | Study abandoned. | Other (stated, no rule matched) |
| NCT01153113 | Human Telomerase Reverse Transcriptase Messenger RNA (hTERT mRNA) Transfected Dendritic… | Phase 1 / Phase 2 | withdrawn | Jun 29, 2010 | University of Florida | IND has been withdrawn and the study is closed. | Other (stated, no rule matched) |
| NCT00418574 | Efficacy Multicentre Trial of ImmunoTherapy Vaccination With Abagovomab to Treat Ovarian…(MIMOSA) | Phase 2 / Phase 3 | terminated | Jan 5, 2007 | Menarini Group | No benefit on primary end point (RFS); no rationale to collect survival data | Other (stated, no rule matched) |
| NCT00926107 | Study of the mTOR Inhibitor Temsirolimus (CCI-779) to Treat Ovarian Cancer With CA125… | Phase 2 | terminated | Jun 23, 2009 | Hellenic Cooperative Oncology Group | The study ended prematurely due to the low accrual rate (24% of the expected accrual rate) in the… | Enrollment / accrual |
| NCT00452387 | Mitoxantrone, Prednisone Plus Sorafenib in Taxane-Refractory Metastatic Hormone… | Phase 2 | terminated | Mar 27, 2007 | Accelerated Community Oncology Research Network | Early stopping rule | Other (stated, no rule matched) |
| NCT00898781 | Study of Circulating Cancer Cells in Patients With Metastatic Breast, Ovarian, Colon, or… | — | terminated | May 12, 2009 | Mayo Clinic | Due to poor accrual | Enrollment / accrual |
| NCT00118300 | Capecitabine and Radiation Therapy in Treating Patients With Locally Advanced Cervical… | Phase 1 | withdrawn | Jul 11, 2005 | Case Comprehensive Cancer Center | Competing studies | Other (stated, no rule matched) |
| NCT01363466 | Evaluation of Hysterectomy After Chemoradiation Therapy for Stage IB2/II Cervical Cancer | Phase 3 | terminated | Jun 1, 2011 | UNICANCER | low recruitment | Enrollment / accrual |
| NCT00117312 | Extension Study Investigating the Long-Term Safety and Tolerability of Repeat Doses of… | Phase 2 | terminated | Jul 6, 2005 | Ferring Pharmaceuticals | After 190 weeks \[7 patients left\] it was terminated for administrative reasons | Other (stated, no rule matched) |
| NCT00215657 | Extension Study Investigating the Long-Term Safety and Tolerability of Repeat Doses of… | Phase 2 | terminated | Sep 22, 2005 | Ferring Pharmaceuticals | The doses were not effective in maintaining testosterone suppression | Other (stated, no rule matched) |
| NCT00245466 | Study Investigating the Long-Term Safety and Tolerability of Repeated Doses of Degarelix… | Phase 2 | terminated | Oct 28, 2005 | Ferring Pharmaceuticals | The maintenance doses were too low to maintain testosterone suppression | Other (stated, no rule matched) |
| NCT00728533 | Open-Label, Randomised Parallel-Group Study | Phase 3 | withdrawn | Aug 6, 2008 | Ferring Pharmaceuticals | Terminated due to awaiting data from Phase II study. | Other (stated, no rule matched) |
| NCT00496067 | Uterine Artery Occlusion for Fibroid Related Bleeding | N/A | terminated | Jul 4, 2007 | Ethicon, Inc. | Data required further pilot work to be undertaken. | Other (stated, no rule matched) |
| NCT00629993 | Dissemination of Cervical Cancer Screening to Primary Care Physicians in Underserved… | Phase 4 | terminated | Mar 6, 2008 | Columbia University | Principal Investigator left the institution | Investigator |
| NCT01140555 | A Pilot Study to Determine Optimal Procedure Steps to Obtain and Maintain Uterine Artery… | N/A | terminated | Jun 9, 2010 | Ethicon, Inc. | Further internal evaluation of the device was required. | Other (stated, no rule matched) |
| NCT00577356 | Docetaxel and Immunotherapy Prior to Prostatectomy for High-Risk Prostate Cancer | Phase 2 | terminated | Dec 20, 2007 | Benaroya Research Institute | Safety reasons, though no safety issues arose. | Safety / toxicity |
| NCT00531778 | NYU Ovarian Cancer Early Detection Program Blood and Genetics | — | terminated | Sep 19, 2007 | NYU Langone Health | insufficient funding and resource | Funding |
| NCT01116154 | Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin… | Phase 1 | terminated | May 4, 2010 | City of Hope Medical Center | Sponsor withdrew support for the study | Other (stated, no rule matched) |
| NCT00952666 | Transrectal Ultrasound Imaging of the Prostate Gland and Neurovascular Bundles During… | Early Phase 1 | terminated | Aug 6, 2009 | Johns Hopkins University | The number of participants needed for this study has been met. | Other (stated, no rule matched) |
| NCT00630799 | Efficacy and Safety Study of a New Leuprolide Acetate 17 mg Depot to Treat Prostate… | Phase 3 | terminated | Mar 7, 2008 | GP-Pharm | not stated | Not stated |
| NCT00355758 | UCI 03-72 Prostate Cancer Detection by Serum Proteomic Profiling | — | terminated | Jul 25, 2006 | University of California, Irvine | Lack of personnel | Other (stated, no rule matched) |
| NCT00312442 | Phase II/III Study of WST09 in Prostate Cancer After Radiation Therapy | Phase 2 / Phase 3 | terminated | Apr 10, 2006 | STEBA France | STEBA decided to develop WST11 that is soluble in aqueous solutions. The property of WST 11 make it… | Other (stated, no rule matched) |
| NCT00258765 | Adjuvant Docetaxel-Zoledronic Acid in High-risk Early Prostate Cancer Following… | Phase 2 | terminated | Nov 28, 2005 | Novartis Pharmaceuticals | Poor recruitment \& not feasible to continue | Enrollment / accrual |
| NCT00082212 | A Study in Patients With Persistent or Recurrent Epithelial Ovarian or Primary Peritoneal… | Phase 2 | terminated | May 5, 2004 | Eli Lilly and Company | Due to lack of sufficient efficacy. | Efficacy / futility |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00277290 | Study of XL999 in Patients With Previously Treated Ovarian Cancer | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT01000896 | Study to Assess Safety and Tolerability of AZD0530 in Combination With Carboplatin and… | Phase 1 | withdrawn | Oct 23, 2009 | AstraZeneca | AstraZeneca has discontinued the development of AZD0530. No new AstraZeneca-sponsored clinical… | Other (stated, no rule matched) |
| NCT00317434 | Maximum Tolerated Dose of Lapatinib When Given With Carboplatin for Recurrent Ovarian… | Phase 1 | terminated | Apr 24, 2006 | University of Alabama at Birmingham | Due to unacceptable non-dose limiting toxicities, excessive treatment delays and limited clinical… | Safety / toxicity |
| NCT00161226 | A Randomized, Controlled, Comparative Study of a Levonorgestrel Intrauterine System for… | — | terminated | Sep 12, 2005 | University of Medicine and Dentistry of New Jersey | Principal investigator left institution | Investigator |
| NCT00176527 | Isotretinoin, Interferon Alfa-2b, Docetaxel, and Estramustine in Treating Patients With… | Phase 2 | terminated | Sep 15, 2005 | University of Medicine and Dentistry of New Jersey | accrual goal met | Enrollment / accrual |
| NCT00391950 | Maintaining Bone Strength in Men With Prostate Cancer | Phase 3 | terminated | Oct 25, 2006 | Novartis | not stated | Not stated |
| NCT00494338 | Phase II Trial of Docetaxel and Celecoxib in Patients With Androgen Independent Prostate… | Phase 2 | terminated | Jun 29, 2007 | Sanofi | due to celecoxib safety issues | Safety / toxicity |
| NCT00610792 | Phase 2 Study of Twice Weekly VELCADE and CAELYX in Patients With Ovarian Cancer Failing… | Phase 2 | withdrawn | Feb 8, 2008 | Millennium Pharmaceuticals, Inc. | Study never submitted to IND. Study is being sponsored by Johnson and Johnson in the EU only. | Other (stated, no rule matched) |
| NCT00921635 | A Study to Evaluate the Impact of Maintaining Hemoglobin Levels in Anemic Patients With…(HOSTT) | Phase 3 | suspended | Jun 16, 2009 | Tri-Service General Hospital (TSGH) | not stated | Not stated |
| NCT00584207 | Radiofrequency Ablation of Uterine Fibroids | Early Phase 1 | terminated | Jan 2, 2008 | University of California, Davis | Unsufficient referrals for recruitment | Enrollment / accrual |
| NCT00753480 | A Study of D4064A Administered to Patients With Recurrent or Persistent Epithelial… | Phase 1 | suspended | Sep 16, 2008 | Genentech, Inc. | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 18, 2012source: clinicaltrials