Phase 1 Trial of Ipilimumab and GVAX in Patients With Metastatic Castration-resistant Prostate Cancer

Inclusion Criteria:

* Males age 18-80 years
* Histologic diagnosis of adenocarcinoma of the prostate
* Metastatic prostate cancer deemed to be unresponsive or refractory to hormone therapy
* Detectable metastases by bone scan, CT scan or MRI
* Two consecutive rising PSA values obtained at least two weeks apart and both obtained at least 4-6 weeks after discontinuation of hormone therapy. Second PSA value must be \> 5.0 ng/mL. LHRH agonist should not be discontinued.
* Testosterone \< 50 ng/dL. Must have had orchiectomy or is currently receiving an LHRH agonist.
* WBC \> 3.0 x 109/L, ANC \> 1.5 x 109/L, hemoglobin \> 6.2 mmol/L, and platelets \> 100 x 109/L
* Serum creatinine \< 177 umol/L Bilirubin \< 1.5 times the upper limit of normal AST \< 3 times the upper limit of normal
* ECOG performance status 0-2
* Life expectancy of at least 6 months
* If sexually active, willing to use barrier contraception during the treatment phase of the protocol
* The ability to understand and willingness to sign a written informed consent

Exclusion Criteria:

* Transitional cell, small cell, neuroendocrine, or squamous cell prostate cancer
* Bone pain severe enough to require routine narcotic analgesia use
* Clinical evidence of brain metastases or history of brain metastases
* Seropositive for HIV, Hepatitis B antigen positive and/or Hepatitis C viremic
* Prior chemotherapy or immunotherapy for prostate cancer
* Radiation therapy within 4 weeks of the first treatment
* Surgery within 4 weeks of the first treatment. Must have recovered from all side effects.
* Flutamide within 4 weeks of the first treatment Megesterol acetate (Megace), finasteride (Proscar), bicalutamide (Casodex),nilutamide, aminoglutethimide, ketoconazole or diethylstilbestrol within 6 weeks of the first treatment.
* Systemic corticosteroid use within 4 weeks of the first treatment
* History of autoimmune disease
* History of another malignancy, except for the following: adequately treated basal cell or squamous cell skin cancer, superficial bladder cancer, adequately treated Stage I or II cancer currently in complete remission or any other cancer that has been in complete remission for at least 5 years