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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,672 stopped studies mapped to Malignant Reproductive System Neoplasm and descendants · 89% state a reason
Over the 1,672 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01735396 | Abiraterone Acetate Trial in African American Prostate Cancer Patients | Phase 2 | terminated | Nov 28, 2012 | Icahn School of Medicine at Mount Sinai | poor accrual | Enrollment / accrual |
| NCT00324324 | Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem… | Phase 3 | terminated | May 11, 2006 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00900068 | Blood Samples From Patients on a Clinical Trial to CINV During HSCT | — | terminated | May 12, 2009 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT01828476 | Navitoclax and Abiraterone Acetate With or Without Hydroxychloroquine in Treating… | Phase 2 | terminated | Apr 10, 2013 | Rutgers, The State University of New Jersey | The Investigator left the organization. | Investigator |
| NCT00603460 | DCVax-L Vaccination With CD3/CD28 Costimulated Autologous T-Cells for Recurrent Ovarian… | Phase 1 / Phase 2 | withdrawn | Jan 29, 2008 | University of Pennsylvania | not stated | Not stated |
| NCT02742428 | Preoperative Ascites Drainage Versus Standard Care for Patients With Advanced Ovarian… | N/A | suspended | Apr 19, 2016 | Gdynia Oncology Center | The protocol will be discussed and consulted. Potentially will resume. | Other (stated, no rule matched) |
| NCT00244894 | Acupuncture in Treating Hot Flashes in Patients With Prostate Cancer | N/A | terminated | Oct 27, 2005 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00459810 | Paclitaxel Poliglumex and Estradiol in Treating Patients With Stage IV Prostate Cancer | Phase 2 | terminated | Apr 13, 2007 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00482274 | Docetaxel in Treating Patients With Relapsed Prostate Cancer | Phase 2 | terminated | Jun 5, 2007 | OHSU Knight Cancer Institute | Drug supplier stopped funding due to loss of study drug (docetaxel) patent. | Funding |
| NCT01494012 | Phase I Stereotactic Body Radiation for Metastatic or Recurrent Platinum-Resistant… | Phase 1 | terminated | Dec 16, 2011 | Stanford University | low accrual | Enrollment / accrual |
| NCT01913015 | Dietary Fat Levels and Abiraterone Acetate Uptake in Patients With Metastatic… | Phase 1 | terminated | Jul 31, 2013 | OHSU Knight Cancer Institute | After enrollment of the first 3 subjects, an interim assessment was conducted. Comparing DBS… | Enrollment / accrual |
| NCT02338141 | Accuracy of Portable Colposcopy and HPV Genotypes Among HIV+ Women | N/A | terminated | Jan 14, 2015 | Duke University | Funding unavailable to perform study. | Funding |
| NCT02840162 | Pre-Prostatectomy Celecoxib or Placebo | Phase 2 | terminated | Jul 21, 2016 | OHSU Knight Cancer Institute | Drug safety concerns | Safety / toxicity |
| NCT02704650 | Identification and Characterization of Ovarian Cancer and Endometrial Cancer Specific… | N/A | withdrawn | Mar 10, 2016 | Shaare Zedek Medical Center | not stated | Not stated |
| NCT00937417 | S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors | Phase 1 | withdrawn | Jul 13, 2009 | SWOG Cancer Research Network | Withdrawn because SWOG no longer pursuing this study at this time | Other (stated, no rule matched) |
| NCT02567396 | Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be… | Phase 1 | withdrawn | Oct 5, 2015 | National Cancer Institute (NCI) | Other- Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT01138137 | N-acetylcysteine Given IV With Cisplatin and Paclitaxel in Patients With Ovarian Cancer | Phase 1 | withdrawn | Jun 7, 2010 | OHSU Knight Cancer Institute | No funding was available for the cost of the IV N-acetylcysteine (NAC). | Funding |
| NCT02247960 | Antibiotic Prophylaxis for Urinary Catheter Removal After Radical Prostatectomy(Abx) | N/A | terminated | Sep 25, 2014 | University of Rochester | Interim analysis determined that the study should be concluded for futility. | Efficacy / futility |
| NCT02370355 | Molecular Characterization of CTCs and ctDNA in Blood and Plasma Samples From Patients… | — | terminated | Feb 24, 2015 | University of Southern California | Sponsor decided not to pursue study | Sponsor / business decision |
| NCT01450683 | Study of Itraconazole in Castrate-resistant Prostate Cancer (CRPC) Post-chemotherapy | Phase 2 | terminated | Oct 12, 2011 | Stanford University | Low accrual | Enrollment / accrual |
| NCT02633254 | Targeted Vessel Ablation of Type 3 Uterine Fibroids With Magnetic Resonance Guided High… | N/A | terminated | Dec 17, 2015 | UMC Utrecht | not stated | Not stated |
| NCT01504308 | Sonalleve Fibroid Ablation Pivotal Clinical Trial for MR-HIFU of Uterine Fibroids(SOFIA) | Phase 2 / Phase 3 | terminated | Jan 5, 2012 | Philips Healthcare | It was not possible to enroll patients into the study in a realistic timeframe. | Enrollment / accrual |
| NCT02067637 | Delayed Effects of Treatment in Cancer Survivors (DETECS)(DETECS) | — | withdrawn | Feb 20, 2014 | University of Colorado, Denver | Low accrual | Enrollment / accrual |
| NCT00738699 | An Efficacy and Safety Study of MORAb-003 in Platinum-Resistant or Refractory Relapsed…(FAR-122) | Phase 2 | terminated | Aug 20, 2008 | Morphotek | study did not meet pre-specified criteria for continuation following interim futility analysis | Efficacy / futility |
| NCT02218502 | Study Into a New Diagnostic Tool (Simple Ultrasound-based Rules) in Patients With Adnexal…(SUBSONiC) | N/A | terminated | Aug 18, 2014 | Maastricht University Medical Center | interim analysis showed incorrect use of simple rules | Efficacy / futility |
| NCT02656615 | Abiraterone-Rechallenge Study for CRPC Patients(ABI-RE) | Phase 2 | terminated | Jan 15, 2016 | Aurelius Omlin | Lack of Patient accrual | Enrollment / accrual |
| NCT02483884 | PET/CT Imaging Study of the Safety and Diagnostic Performance of [68Ga]RM2 in Patients… | Phase 1 / Phase 2 | terminated | Jun 29, 2015 | Lantheus Biosciences Ltd. | Business decision | Sponsor / business decision |
| NCT01155791 | Phase I Sodium Selenite in Combination With Docetaxel in Castration-resistant Prostate… | Phase 1 | terminated | Jul 2, 2010 | Sandy Srinivas | not stated | Not stated |
| NCT01659554 | A Phase II Combined Modality Protocol of Debulking Surgery With HIPEC Followed by…(HIPEC) | Phase 2 | terminated | Aug 8, 2012 | Columbia University | Principal Investigator left institution | Investigator |
| NCT00883116 | A Study of Ixabepilone as Second-line Therapy for Locally Advanced, Recurrent, or…(IXAMPLE2) | Phase 3 | terminated | Apr 17, 2009 | R-Pharm | Interim analysis results showed that ixabepilone did not improve survival compared with control… | Efficacy / futility |
| NCT01933022 | A Study in Patients With Metastatic Prostate Cancer to Assess How the Drug Eligard®,…(EFFECT) | Phase 4 | terminated | Aug 30, 2013 | Astellas Pharma Europe Ltd. | Termination due to high current screen rate failure and unreliable PSA mRNA assay. | Other (stated, no rule matched) |
| NCT01087580 | Docetaxel + Prednisone With or Without Radiation for Castrate Resistant Prostate Cancer | Phase 2 | withdrawn | Mar 16, 2010 | Northwestern University | not stated | Not stated |
| NCT01137071 | Consolidation Therapy With Hu3S193 for Women With Ovarian, Primary Peritoneal or… | Phase 2 | terminated | Jun 4, 2010 | Recepta Biopharma | Total number of pts expected to be enrolled would not be met. | Enrollment / accrual |
| NCT01493505 | TRINOVA-3: A Study of AMG 386 or AMG 386 Placebo in Combination With Paclitaxel and… | Phase 3 | terminated | Dec 16, 2011 | Amgen | Amgen Administrative Decision - termination of LTFU | Other (stated, no rule matched) |
| NCT01817738 | Trial of RNActive®-Derived Prostate Cancer Vaccine in Metastatic Castrate-refractory… | Phase 1 / Phase 2 | terminated | Mar 25, 2013 | CureVac | Follow up period after primary analysis was prematurely stopped because more mature data will not… | Other (stated, no rule matched) |
| NCT00946283 | Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant… | N/A | terminated | Jul 24, 2009 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT00823771 | A Pilot Study to Assess the Follow-up of Prostate Cancer Patients Who Have Undergone…(PROFUGO) | — | terminated | Jan 16, 2009 | Barwon Health | Data review showed that the study was underpowered to draw clear conlcusions | Other (stated, no rule matched) |
| NCT02421575 | Hydroxychloroquine in Blocking Autophagy in Patients With Prostate Cancer Undergoing… | Early Phase 1 | terminated | Apr 20, 2015 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT00629577 | Gene Expression Profiling of Cervical Cancer Progression in Biopsies and Tissue Samples(SAGE) | Phase 1 | terminated | Mar 6, 2008 | British Columbia Cancer Agency | no funding | Funding |
| NCT00879619 | Taxotere/Prednisone Plus Sunitinib in Chemotherapy-Naïve, Hormone Refractory Prostate… | Phase 1 / Phase 2 | terminated | Apr 10, 2009 | John P. Fruehauf | Terminated due to slow accrual. | Enrollment / accrual |
| NCT00584909 | A Phase II Study of Paclitaxel and Carboplatin in Patients With an Elevated-Risk Cancer… | Phase 2 | terminated | Jan 2, 2008 | University of Alabama at Birmingham | low accrual | Enrollment / accrual |
| NCT01762956 | Pelvic Floor Muscles Training in Men Undergoing Radiotherapy for Prostate Cancer:… | N/A | terminated | Jan 8, 2013 | University of Sao Paulo | Unobtainable sample size | Other (stated, no rule matched) |
| NCT01699672 | Group-based or Individual Information About Disease and Treatment Plan | N/A | terminated | Oct 4, 2012 | Norwegian University of Science and Technology | Problems recruiting patients (not willing, travel time, no respons) | Enrollment / accrual |
| NCT01748110 | Health Interventions in Men Undergoing Radical Prostatectomy(HIM-UP) | N/A | withdrawn | Dec 12, 2012 | Johns Hopkins University | Funding could not be secured | Funding |
| NCT01971060 | a Study to Evaluate Adhesion Risk in Fertility Patients' Status Post Laparoscopic…(VLocmyo) | N/A | withdrawn | Oct 28, 2013 | The Advanced Gynecologic Surgery Institute | lack of funding | Funding |
| NCT00550654 | Conformal Radiation Therapy in Treating Patients With Metastatic Cancer Outside the Brain | Phase 2 | terminated | Oct 30, 2007 | National Institutes of Health Clinical Center (CC) | Study was terminated due to poor accrual. | Enrollment / accrual |
| NCT01913197 | Using Magnetic Resonance Imaging (MRI) to Guide Differential-Dose Prostate Brachytherapy | Phase 1 / Phase 2 | terminated | Jul 31, 2013 | St. Luke's-Roosevelt Hospital Center | low enrollment | Enrollment / accrual |
| NCT00686036 | Trial Assessing Zactima Against Placebo in Prostate Cancer Subjects Undergoing…(ZENITH) | Phase 2 | terminated | May 29, 2008 | Genzyme, a Sanofi Company | Slow recruitment | Enrollment / accrual |
| NCT00452920 | Docetaxel and Radiation Therapy in Treating Patients With Stage II, Stage III, or Stage… | Phase 1 / Phase 2 | withdrawn | Mar 28, 2007 | University of Miami | not stated | Not stated |
| NCT01521143 | Cvac as Maintenance Treatment in Patients With Epithelial Ovarian Cancer in Complete…(CANVAS) | Phase 2 | terminated | Jan 30, 2012 | Prima BioMed Ltd | The study was terminated due to company restructuring and changes in drug development priorities. | Sponsor / business decision |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated May 12, 2017source: clinicaltrials