Clinical trial · Interventional
Pre-Prostatectomy Celecoxib or Placebo
Randomized Study of Pre-Prostatectomy Celecoxib or Placebo
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Drug safety concerns
Summary
Brief summary (as posted)
This study will seek to determine if the downstream effects of cyclooxygenase-2 (COX-2) inhibition suggested by preclinical systems occur in human prostate cancer. To answer this question, men who have chosen prostatectomy will be randomly assigned to preoperative treatment with celecoxib or placebo for four weeks. Carefully collected tumor, premalignant, and benign prostate tissue will then be examined for apoptosis, androgen receptor and prostaglandin E2 levels. Tumor COX-2 expression will be correlated with observed treatment effects. The data generated by this study will serve as a foundation for the development of COX-2 targeted therapies for prostate cancer, will provide preliminary evidence for larger scale clinical trials aimed at treatment and prevention of prostate cancer, and will validate current preclinical models used to study COX-2 in prostate cancer.
Conditions
Conditions (2)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Adenocarcinoma of the Prostate | Prostate Adenocarcinoma | ALIAS | 0.90 |
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Celecoxib | Drug | Celecoxib | ALIAS |
| Placebo | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- Celecoxib
- description
- Treated patients will receive 4 weeks of celecoxib at 400 mg twice daily by mouth
- interventionNames
- Drug: Celecoxib
- type
- PLACEBO_COMPARATOR
- label
- Placebo
- description
- Control patients will receive a suitable placebo for 4 weeks, twice daily by mouth
- interventionNames
- Drug: Placebo
Primary outcomes (1)
- measure
- Apoptosis Index, defined as the percent positive staining cells
- timeFrame
- approximately 4 weeks of treatment
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Histopathologically or cytologically proven adenocarcinoma of the prostate and planned prostatectomy * Age \>= 18 * Performance status (ECOG \<= 2) * Hemoglobin \> 10 g/dL (within 4 weeks) * Creatinine \<= 1.5 mg/dL * Signed informed patient consent Exclusion Criteria: * Other preoperative or prior treatment directed at prostate cancer * Significant active medical illness which in the opinion of the investigator would preclude protocol treatment * Use of non-steroidal anti-inflammatory agents within seven days of celecoxib treatment * Hypersensitivity to celecoxib * A history of asthma, urticaria, or anaphylaxis precipitated by an NSAID * History of significant upper gastrointestinal bleeding or active peptic ulcer disease * Current treatment with anticoagulants * Allergy to sulfonamide
References
Publications (0)
Data not yet available