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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
12,383 stopped studies mapped to Malignant Neoplasm and descendants · 89% state a reason
Over the 12,383 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00131651 | ATN-161 in Advanced Renal Cell Cancer | Phase 2 | terminated | Aug 19, 2005 | Attenuon | not stated | Not stated |
| NCT00367497 | Safety and Efficacy Study of Salvage Chemotherapy (R-ESHAP) to Treat Relapsed and… | Phase 2 | terminated | Aug 23, 2006 | Keio University | The stopping rule was applied because of low response rates. | Other (stated, no rule matched) |
| NCT00120172 | Study of Oxaliplatin, Capecitabine, and Bevacizumab to Treat Older Patients With… | Phase 2 | terminated | Jul 15, 2005 | Geriatric Oncology Consortium | positive results from a larger study with same regimen was released. | Other (stated, no rule matched) |
| NCT00120198 | Pegylated Liposomal Doxorubicin Containing Chemotherapy in the Treatment of Older… | Phase 2 | terminated | Jul 15, 2005 | Geriatric Oncology Consortium | slow accrual | Enrollment / accrual |
| NCT00215748 | Reduced Dexamethasone Pre-Medication Dose in Elderly Patients Receiving Weekly Docetaxel | Phase 2 | terminated | Sep 22, 2005 | Geriatric Oncology Consortium | slow accrual | Enrollment / accrual |
| NCT00559351 | RCT on the Combined Modality Treatment of Squamous Cell Carcinoma of the Esophagus | Phase 3 | terminated | Nov 16, 2007 | Ministry of Scientific Research and Information Technology, Poland | difficulty in recruitment | Enrollment / accrual |
| NCT00216424 | Capecitabine (Xeloda) and Radiation for Patients With Rectosigmoid Carcinoma | Phase 4 | terminated | Sep 22, 2005 | James A. Haley Veterans Administration Hospital | lack of accrual | Enrollment / accrual |
| NCT00216437 | Dose Escalation Study Combining Oral Capecitabine (Xeloda) and Radiotherapy for Patients… | Phase 1 | terminated | Sep 22, 2005 | James A. Haley Veterans Administration Hospital | lack of accrual | Enrollment / accrual |
| NCT00273338 | DN-101 in Combination With Docetaxel in Androgen-Independent Prostate Cancer (AIPC) (AIPC… | Phase 3 | terminated | Jan 9, 2006 | Novacea | DSMB | Other (stated, no rule matched) |
| NCT00536770 | A Study of Gemcitabine ± Erlotinib and DN-101 Versus Gemcitabine ± Erlotinib and Placebo… | Phase 2 | suspended | Sep 28, 2007 | Novacea | DSMB | Other (stated, no rule matched) |
| NCT00047632 | Safety and Efficacy of Interferon Gamma-1b Plus Chemotherapy for Ovarian and Peritoneal… | Phase 3 | terminated | Oct 11, 2002 | InterMune | futility | Efficacy / futility |
| NCT00057447 | Safety of Interferon Gamma-1b With Rituximab in Non-Hodgkin's Lymphoma Patients | Phase 1 / Phase 2 | terminated | Apr 3, 2003 | InterMune | administrative reasons | Other (stated, no rule matched) |
| NCT00209677 | Phase I/II Study of Oral S-1 Plus Gemcitabine in Patients With Metastatic Pancreatic… | Phase 1 / Phase 2 | suspended | Sep 21, 2005 | Hokkaido Gastrointestinal Cancer Study Group | Unfortunately, other Phase III clinical Study (GEM+S-1 vs GEM vs S-1) have been started in Japan. h | Other (stated, no rule matched) |
| NCT00316745 | IRIS Followed by mFOLFOX6 or the Reverse Sequence in Advanced Colorectal Cancer | Phase 3 | suspended | Apr 21, 2006 | Hokkaido Gastrointestinal Cancer Study Group | Because of approval of Bevacizumab, it was difficult to perform clinical study in 1st line setting. | Other (stated, no rule matched) |
| NCT00255268 | CMAB vs IMAB in Metastatic Prostate Cancer | Phase 4 | withdrawn | Nov 18, 2005 | AstraZeneca | not stated | Not stated |
| NCT00189579 | Addition of Herceptin to a Carboplatin-Paclitaxel Regimen in Patients With Ovarian Cancer | Phase 2 | terminated | Sep 19, 2005 | ARCAGY/ GINECO GROUP | not stated | Not stated |
| NCT00061646 | Safety and Effectiveness of ABT-510 Plus Combination Chemotherapy in Subjects With… | Phase 2 | terminated | Jun 4, 2003 | Abbott | Enrollment suspended based upon interim analysis; subjects allowed to stay on study until disease… | Efficacy / futility |
| NCT00514332 | Comparison Between Colorectal Stents and Primary Surgery in Obstructive Colonic Cancer. A… | N/A | terminated | Aug 9, 2007 | University Hospital, Montpellier | enrolling participants stopped | Enrollment / accrual |
| NCT00511121 | Study of the Combination of a Tyrosine Kinase Inhibitor (STI571) and a Pegylated Human… | Phase 2 | terminated | Aug 3, 2007 | University of Bologna | not stated | Not stated |
| NCT00100347 | Safety/Tolerance Study of PPI-2458 in Subjects With Non-Hodgkin's Lymphoma and Solid… | Phase 1 | terminated | Dec 30, 2004 | PRAECIS Pharmaceuticals Inc. | terminated due to corporate transaction. | Other (stated, no rule matched) |
| NCT00195078 | Safety Trial of IRESSA, Cisplatin and Radiation Therapy for Patients With Head and Neck… | Phase 1 / Phase 2 | terminated | Sep 19, 2005 | Weill Medical College of Cornell University | not stated | Not stated |
| NCT00496743 | Study of Low-Dose Total Skin Electron Beam Therapy in Mycosis Fungoides | N/A | terminated | Jul 4, 2007 | Bispebjerg Hospital | The study was discontinued after the first 10 patients because of discouraging results. | Other (stated, no rule matched) |
| NCT00105313 | Study to Evaluate MEDI-507 in Patients With CD2-Positive Lymphoma/Leukemia | Phase 1 | terminated | Mar 14, 2005 | MedImmune LLC | After review of safety events and have decided that further dose escalation of MEDI-507 as a single… | Safety / toxicity |
| NCT00116389 | Trial of Talabostat and Gemcitabine in Patients With Stage IV Adenocarcinoma of the… | Phase 2 | terminated | Jun 29, 2005 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00243204 | Study of Talabostat + Docetaxel Versus Docetaxel in Stage IIIB/IV Non-Small Cell Lung… | Phase 3 | terminated | Oct 21, 2005 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00290017 | Study of Talabostat and Pemetrexed vs. Pemetrexed in Stage IIIB/IV Non-Small Cell Lung… | Phase 3 | terminated | Feb 10, 2006 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00126893 | Study to Determine the Optimal Biologic Dose of CC-401 in Subjects With High-Risk Myeloid… | Phase 1 | terminated | Aug 5, 2005 | Celgene Corporation | not stated | Not stated |
| NCT00080028 | Motexafin Gadolinium With Chemotherapy and Radiation Therapy for the Treatment of… | Phase 1 | terminated | Mar 23, 2004 | Pharmacyclics LLC. | not stated | Not stated |
| NCT00143884 | Study of Low Intensity Conditioning and Immunotherapy for High-Risk Cancers of the Blood | Phase 2 | terminated | Sep 2, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT00225056 | Phase II Study of Capecitabine and Weekly Docetaxel Followed by Capecitabine Maintenance… | Phase 2 | terminated | Sep 23, 2005 | Oncology Specialties, Alabama | Terminated due to lack of accrual | Enrollment / accrual |
| NCT00229567 | Intra-op Lidocaine and Ketamine Effect on Postoperative Bowel Function | N/A | terminated | Sep 29, 2005 | University of Saskatchewan | insufficient numbers of eligible patients as laparscopic surgery increased and open surgery… | Other (stated, no rule matched) |
| NCT00106262 | Study of Velcade and Irinotecan in Advanced Cervical, Vulvar, or Vaginal Cancer | Phase 2 | terminated | Mar 22, 2005 | Women and Infants Hospital of Rhode Island | Lack of accrual | Enrollment / accrual |
| NCT00316433 | Oxaliplatin/CPT-11 for Extensive Stage Small Cell Lung Cancer | Phase 2 | terminated | Apr 20, 2006 | Swedish Medical Center | not stated | Not stated |
| NCT00099281 | DPPE in Combination With Epirubicin and Cyclophosphamide in the Treatment of Breast Cancer | Phase 3 | terminated | Dec 10, 2004 | YM BioSciences | not stated | Not stated |
| NCT00287482 | Essiac (ESIAK) Versus Placebo to Improve Quality of Life in Transition in Women With… | N/A | terminated | Feb 6, 2006 | Women and Infants Hospital of Rhode Island | not stated | Not stated |
| NCT00133302 | Study of Standard CHOP Versus Biweekly CHOP in Aggressive Non-Hodgkin's Lymphoma… | Phase 3 | terminated | Aug 23, 2005 | Japan Clinical Oncology Group | not stated | Not stated |
| NCT00420862 | The DANTE Trial. A Randomized Study on Lung Cancer Screening With Low-Dose Spiral… | Phase 3 | terminated | Jan 11, 2007 | Istituto Clinico Humanitas | not stated | Not stated |
| NCT00123877 | Study of GPX-100 in the Treatment of Metastatic Breast Cancer | Phase 2 | terminated | Jul 26, 2005 | Gem Pharmaceuticals | not stated | Not stated |
| NCT00152594 | Voriconazole or Placebo in the Prophylaxis of Lung Infiltrates in Patients Undergoing… | Phase 3 | terminated | Sep 9, 2005 | University of Cologne | not stated | Not stated |
| NCT00132756 | Liposomal Doxorubicin and Estramustine Phosphate: Study in Taxane Resistant, Hormone… | Phase 1 / Phase 2 | terminated | Aug 22, 2005 | Morton Plant Mease Health Care | not stated | Not stated |
| NCT00129948 | Study for Patients With Relapsed or Refractory Acute Myeloid Leukemia (AML) | Phase 2 | terminated | Aug 12, 2005 | SGX Pharmaceuticals, Inc. | not stated | Not stated |
| NCT00395655 | Hydralazine and Valproate Added to Chemotherapy for Breast Cancer | Phase 2 | terminated | Nov 3, 2006 | National Institute of Cancerología | not stated | Not stated |
| NCT00224692 | Analgesic Effect in Children of Low-Dose Ketamine for Mucositis Treated by… | Phase 3 | terminated | Sep 23, 2005 | Assistance Publique - Hôpitaux de Paris | not stated | Not stated |
| NCT00329498 | L-Ascorbic Acid Depletion to Treat Acute Myeloid Leukemia and Myelodysplastic Syndromes | Phase 2 | suspended | May 24, 2006 | Samsung Medical Center | not stated | Not stated |
| NCT00103623 | The Plenaxis® Experience Study | Phase 4 | suspended | Feb 14, 2005 | PRAECIS Pharmaceuticals Inc. | not stated | Not stated |
| NCT00055432 | Gemzar (Gemcitabine) and Alimta (Pemetrexed) in the Treatment of Patients With Recurrent… | Phase 2 | terminated | Mar 4, 2003 | Eli Lilly and Company | not stated | Not stated |
| NCT00194935 | Weekly Topotecan Therapy in Patients With Ovarian Cancer | Phase 2 | terminated | Sep 19, 2005 | Weill Medical College of Cornell University | not stated | Not stated |
| NCT00220532 | Folate and Protection Against Cervical Cancer | Phase 1 / Phase 2 | terminated | Sep 22, 2005 | Sheffield Teaching Hospitals NHS Foundation Trust | not stated | Not stated |
| NCT00057343 | Safety and Efficacy of Zevalin in the Treatment of Non-Hodgkin's Lymphoma | Phase 3 | terminated | Apr 1, 2003 | Biogen | not stated | Not stated |
| NCT00127088 | Study of Peri-Operative Docetaxel Plus Laparoscopic Radical Prostatectomy in Prostate… | Phase 2 | suspended | Aug 5, 2005 | Gustave Roussy, Cancer Campus, Grand Paris | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Dec 6, 2007source: clinicaltrials