Clinical trial · Interventional
Folate and Protection Against Cervical Cancer
A Randomised Placebo-Controlled Trial to Evaluate Interactions Between Riboflavin and Folate Intake and Genotype in Reducing Risk of Cervical Cancer
NCT00220532CI-TRIAL-00000442terminatedPhase 1 / Phase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This is a randomised double-blind placebo-controlled trial to see whether giving a low dose of the vitamins folic acid and riboflavin is beneficial to women who have very low grade abnormalities of the cervical cells.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Cancer | Malignant Cervical Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Folic acid with riboflavin | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Rate of regression of CIN1 to normal over a 12 month intervention
Secondary outcomes (4)
- measure
- DNA strand breakage, in cervical cells
- measure
- DNA hypomethylation, in cervical cells
- measure
- Cervical cell folic acid
- measure
- HPV persistence over 12 months of intervention
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 0 Years
Show eligibility criteria text
Inclusion Criteria: * biopsy-diagnosed CIN1 infection with oncogenic HPV Exclusion Criteria: Any other stage of cervical abnormality pregnant or planning a pregnancy diabetic taking B vitamin supplements taking anti-epileptic treatment taking methotrexate bleeding after intercourse abnormal GI function infection with chlamydia, HIV or other agent
References
Publications (0)
Data not yet available
No reference posted for this study.