Clinical trial · Interventional
Intra-op Lidocaine and Ketamine Effect on Postoperative Bowel Function
A Randomised Controlled Trial of Lidocaine Infusion Plus Ketamine Injection Versus Placebo to Decrease Postoperative Ileus
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): insufficient numbers of eligible patients as laparscopic surgery increased and open surgery decreased.
Summary
Brief summary (as posted)
Bowel function after bowel surgery is delayed (postoperative ileus)by both opiates and the surgery itself. We hypothesized that decreasing opiate use by other analgesics will speed the return of bowel function after surgery. Lidocaine and Ketamine are drugs that appear to be synergistic and do not slow peristalsis. This study is a Randomised Controlled Trial of Lidocaine Infusion Plus Ketamine Injection versus Placebo to to determine whether they will decrease opiate use and then whether decreased opiate use will speed the return of bowel function.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Colorectal Cancer | Malignant Colorectal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Lidocaine infusion plus ketamine injection | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (5)
- measure
- Mean time after surgery to completion of the following postoperative markers:
- measure
- drinking and retaining 500ml clear fluids,
- measure
- presence of bowel sounds
- measure
- passage of flatus, and
- measure
- passage of stool.
Secondary outcomes (6)
- measure
- pain after cough by VAS
- measure
- narcotic usage
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 79 Years
Show eligibility criteria text
Inclusion Criteria: * age 18 to 79 * booked for urgent or elective colon surgery undergoing a left, right, or transverse hemicolectomy via laparotomy Exclusion Criteria: * patients requiring emergency surgery * pregnant subjects or those who might be pregnant * subjects allergic to lidocaine, ketamine, morphine, naproxen, or acetaminophen * subjects with epidural analgesia * subjects unable to understand and implement a Patient-Controlled Intravenous Analgesia system * subjects who do not know English well enough to understand the consent form and assessments * subjects with known hepatic or renal failure or cardiac dysrhythmias or atrioventricular block * patients with pre-existing functional bowel motility disorders including Crohn's disease and ulcerative colitis * daily use of laxatives, inability to have a bowel movement without laxatives, use of suppositories or enemas on a daily basis, or use of antimotility agents * patients with Parkinson's disease
References
Publications (0)
Data not yet available