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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
12,388 stopped studies mapped to Malignant Neoplasm and descendants · 89% state a reason
Over the 12,388 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00677326 | Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 14, 2008 | Tokyo University | Difficulty in recruiting | Enrollment / accrual |
| NCT00677612 | Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 14, 2008 | Tokyo University | Lack of financial support | Funding |
| NCT00678509 | Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 15, 2008 | Tokyo University | Lack of financial support | Funding |
| NCT00271323 | Safety Study of Docetaxel/Cisplatin Induction Therapy Followed by Concurrent… | Phase 2 | terminated | Dec 30, 2005 | Sanofi | not stated | Not stated |
| NCT00317434 | Maximum Tolerated Dose of Lapatinib When Given With Carboplatin for Recurrent Ovarian… | Phase 1 | terminated | Apr 24, 2006 | University of Alabama at Birmingham | Due to unacceptable non-dose limiting toxicities, excessive treatment delays and limited clinical… | Safety / toxicity |
| NCT00161226 | A Randomized, Controlled, Comparative Study of a Levonorgestrel Intrauterine System for… | — | terminated | Sep 12, 2005 | University of Medicine and Dentistry of New Jersey | Principal investigator left institution | Investigator |
| NCT00161239 | LAMPP Trial for Peripheral and Cutaneous T-Cell Lymphoma | N/A | terminated | Sep 12, 2005 | University of Medicine and Dentistry of New Jersey | toxicity | Safety / toxicity |
| NCT00176527 | Isotretinoin, Interferon Alfa-2b, Docetaxel, and Estramustine in Treating Patients With… | Phase 2 | terminated | Sep 15, 2005 | University of Medicine and Dentistry of New Jersey | accrual goal met | Enrollment / accrual |
| NCT00323791 | Gemcitabine With or Without Imatinib Mesylate in Treating Patients With Metastatic or… | Phase 2 | terminated | May 10, 2006 | University of Medicine and Dentistry of New Jersey | slow accrual | Enrollment / accrual |
| NCT00667901 | Riluzole in Treating Patients With Stage III or Stage IV Melanoma That Can Be Removed by… | Phase 1 | terminated | Apr 28, 2008 | University of Medicine and Dentistry of New Jersey | All enrollment, treatment, follow-up \& data analysis completed | Enrollment / accrual |
| NCT00434356 | A Study of Sunitinib in Combination With Bevacizumab and Paclitaxel in Previously… | Phase 2 | terminated | Feb 13, 2007 | Genentech, Inc. | Based on data collected, the combination appeared to be poorly tolearated. | Other (stated, no rule matched) |
| NCT00557596 | A Phase 1-2, XIAP Antisense AEG35156 With Gemcitabine in Patients With Advanced… | Phase 1 / Phase 2 | terminated | Nov 14, 2007 | Aegera Therapeutics | not stated | Not stated |
| NCT00712621 | Determining Quality of Life in Breast Cancer Patient After Completing… | Phase 2 | withdrawn | Jul 10, 2008 | American Scitech International | Study is withdrawn due to unavailability of eligible subject population. We will request the… | Enrollment / accrual |
| NCT00243763 | TKI258 in Subjects With Refractory or Relapsed Multiple Myeloma | Phase 1 | terminated | Oct 25, 2005 | Novartis | not stated | Not stated |
| NCT00391950 | Maintaining Bone Strength in Men With Prostate Cancer | Phase 3 | terminated | Oct 25, 2006 | Novartis | not stated | Not stated |
| NCT00362466 | A Study of Dasatinib vs. High-Dose Imatinib (600 mg) in Patients With Chronic Phase… | Phase 3 | terminated | Aug 10, 2006 | Bristol-Myers Squibb | Insufficient Enrollment | Enrollment / accrual |
| NCT00494026 | Chemotherapy and Radiotherapy to Treat Patients With Limited Stage of Small Cell Lung… | Phase 2 | terminated | Jun 29, 2007 | Eli Lilly and Company | Study stopped early based on interim results of another trial, showing inferior activity of… | Other (stated, no rule matched) |
| NCT00387153 | Phase 1 Clinical Trial MPC-2130 Treatment of Blood Cancers / Refractory Cancer | Phase 1 | terminated | Oct 12, 2006 | Myriad Therapeutics, Inc. | Last subject enrolled experienced bradycardia; study was terminated by Sponsor. | Enrollment / accrual |
| NCT00447421 | A Study to Treat Small Cell Lung Cancer With a Combination of Cisplatin, Pemetrexed, and… | Phase 1 / Phase 2 | terminated | Mar 14, 2007 | Eli Lilly and Company | Interim results of another trial showed inferior activity of treatment | Other (stated, no rule matched) |
| NCT00494338 | Phase II Trial of Docetaxel and Celecoxib in Patients With Androgen Independent Prostate… | Phase 2 | terminated | Jun 29, 2007 | Sanofi | due to celecoxib safety issues | Safety / toxicity |
| NCT00313768 | Randomized Ph 2 Trial Of Paclitaxel/Carboplatin /Bevacizumab + PF-3512676 And P/C/B Alone… | Phase 2 | terminated | Apr 12, 2006 | Pfizer | See Termination Reason in Detailed Description. | Other (stated, no rule matched) |
| NCT00321308 | Trial of Pemetrexed With or Without PF-3512676 in Advanced Non-Small Cell Lung Cancer | Phase 2 | terminated | May 3, 2006 | Pfizer | See Termination Reason in Detailed Description. | Other (stated, no rule matched) |
| NCT00471367 | Phase I, Open-label, Dose-escalation, Safety and PK Study of AZD4877 | Phase 1 | terminated | May 9, 2007 | AstraZeneca | Part B of the study was terminated early due to a lack of enrollment. | Enrollment / accrual |
| NCT00273507 | Neoadjuvant Chemotherapy in Non Small Cell Lung Cancer (NSCLC) Stages IB, IIA, IIB, and… | Phase 3 | terminated | Jan 9, 2006 | Rigshospitalet, Denmark | not stated | Not stated |
| NCT00354822 | Fludarabine,Cyclophosphamide and Rituximab Followed by Zevalin for Non-Follicular…(Z0105) | Phase 2 | terminated | Jul 20, 2006 | A.O. Ospedale Papa Giovanni XXIII | Inability to recruit in time a sufficient number of patients | Enrollment / accrual |
| NCT00376103 | Radiation Boost for Newly Diagnosed Glioblastoma Multiforme | Phase 1 / Phase 2 | terminated | Sep 14, 2006 | Methodist Healthcare - Memphis | Loss of funding from sponsor | Funding |
| NCT00548938 | Gliadel Wafer, Temozolomide and Radiation Therapy for Newly Diagnosed GBM | Phase 2 | terminated | Oct 24, 2007 | Methodist Healthcare - Memphis | Principal Investigator has left the institution | Investigator |
| NCT00963664 | Evaluation of Interferon-Lovastatin Therapy for Malignant Melanoma | Phase 2 | withdrawn | Aug 21, 2009 | NeoPlas Innovation | Modifications will be necessary before full IRB approval will be secured. | Other (stated, no rule matched) |
| NCT00461110 | A Study of BMS-663513 in Combination With Chemoradiation in Subjects With Non Small Cell… | Phase 1 | terminated | Apr 17, 2007 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00474188 | A Study to Evaluate Lenalidomide Combined With Dexamethasone in Relapsed or Refractory… | Phase 2 | terminated | May 16, 2007 | Celgene Corporation | Business decision | Sponsor / business decision |
| NCT00868647 | Radiofrequency Ablation (RFA) Of Tumors Acquired In Childhood | Phase 2 | suspended | Mar 25, 2009 | Seattle Children's Hospital | not stated | Not stated |
| NCT00434226 | A Study of Sunitinib in Combination With Bevacizumab, Carboplatin, and Paclitaxel in… | Phase 2 | terminated | Feb 13, 2007 | Genentech, Inc. | Based on data collected, the combination appeared to be poorly tolearated. | Other (stated, no rule matched) |
| NCT00306332 | T-cell and B-cell Depletion in Allogeneic Peripheral Blood Stem Cell Transplantation | Phase 3 | terminated | Mar 23, 2006 | Radboud University Medical Center | Interim analysis has shown that the objectives of this study can not be reached | Efficacy / futility |
| NCT00539318 | Infrastructure for Developing Gastrointestinal Cancer Prognostic and Predictive Markers | — | terminated | Oct 4, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low Recruitment | Enrollment / accrual |
| NCT00307723 | Study of Bevacizumab in Combination With 5-FU, Oxaliplatin and External Beam Radiation… | Phase 1 / Phase 2 | terminated | Mar 28, 2006 | Massachusetts General Hospital | poor accrual | Enrollment / accrual |
| NCT00770354 | Phase II Study of AS1402 Combined With Letrozole to Treat Breast Cancer | Phase 2 | terminated | Oct 10, 2008 | Antisoma Research | not stated | Not stated |
| NCT00955292 | Dose-escalation Study of Quarfloxin in Patients With Advanced Solid Tumors or Lymphomas | Phase 1 | terminated | Aug 10, 2009 | Cylene Pharmaceuticals | Modified dose schedule presented no advantage over previously studied schedule | Other (stated, no rule matched) |
| NCT00465673 | Liposomal Doxorubicin (Lipo-Dox) in Patients With Brain Metastasis From Breast Cancer | Phase 2 | terminated | Apr 25, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low recruitment | Enrollment / accrual |
| NCT00354900 | Phase I Study of Aprotinin in Advanced Breast Cancer | Phase 1 | terminated | Jul 20, 2006 | Dartmouth-Hitchcock Medical Center | The FDA changed the labeling for this agent, and we felt we could not offer it to patients on a… | Other (stated, no rule matched) |
| NCT00622804 | Comparison Study for Bile Reflux and Gastric Stasis in Patients After Distal Gastrectomy | Phase 3 | withdrawn | Feb 25, 2008 | The Catholic University of Korea | It was very difficult to enroll patients in this study. | Enrollment / accrual |
| NCT00558922 | A Phase 1-2 XIAP Antisense AEG35156 With Carboplatin and Paclitaxel in Patients With… | Phase 1 / Phase 2 | terminated | Nov 15, 2007 | Aegera Therapeutics | Unacceptable Neurotoxicity (2 cases) | Other (stated, no rule matched) |
| NCT00532025 | Sorafenib in Resected Non-small Cell Lung Carcinoma(SIRN) | Phase 2 | terminated | Sep 19, 2007 | Johannes Gutenberg University Mainz | not stated | Not stated |
| NCT00610792 | Phase 2 Study of Twice Weekly VELCADE and CAELYX in Patients With Ovarian Cancer Failing… | Phase 2 | withdrawn | Feb 8, 2008 | Millennium Pharmaceuticals, Inc. | Study never submitted to IND. Study is being sponsored by Johnson and Johnson in the EU only. | Other (stated, no rule matched) |
| NCT00568464 | Study on VCD/IE in the Patients With Ewing's Sarcoma Family of Tumors (ESFT) | Phase 2 | terminated | Dec 6, 2007 | Fudan University | The enrollment is slower than expected | Enrollment / accrual |
| NCT00595985 | Sorafenib as a Second Line Treatment in Patients With Advanced or Metastatic Gastric… | Phase 2 | terminated | Jan 16, 2008 | Fudan University | low response rate, no evidence of PFS or OS improved. | Other (stated, no rule matched) |
| NCT00234442 | Iressa in the Treatment of Brain Metastases From Non Small Cell Lung Cancer | Phase 2 | terminated | Oct 7, 2005 | AstraZeneca | Closed due to insufficient recruitment. | Enrollment / accrual |
| NCT00522639 | Predictive Value of FDG-PET-CT Scans for Patients With Lung Cancer Receiving Concurrent…(FDG-PET lung) | Phase 3 | terminated | Aug 30, 2007 | Maastricht Radiation Oncology | Poor accrual | Enrollment / accrual |
| NCT00441025 | The Effectiveness of Alemtuzumab Combination With CHOP to Treat Patients Newly Diagnosed… | Phase 2 | terminated | Feb 27, 2007 | Mahidol University | a lack of a potential patient. | Other (stated, no rule matched) |
| NCT00921635 | A Study to Evaluate the Impact of Maintaining Hemoglobin Levels in Anemic Patients With…(HOSTT) | Phase 3 | suspended | Jun 16, 2009 | Tri-Service General Hospital (TSGH) | not stated | Not stated |
| NCT00523094 | Vibration Response Imaging (VRI) in Patients That Are Candidates for Undergoing Pulmonary… | — | suspended | Aug 30, 2007 | Deep Breeze | Enrollment was too slow and principal investigator moved to another country | Investigator |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Dec 29, 2009source: clinicaltrials