Clinical trial · Interventional
Trial of Pemetrexed With or Without PF-3512676 in Advanced Non-Small Cell Lung Cancer
A Randomized Phase II Trial Of Pemetrexed With Or Without PF-3512676 For The Treatment Of Patients With Locally Advanced Or Metastatic Non-Small Cell Lung Cancer After Failure Of One Prior Chemotherapy Regimen For Advanced Disease
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): See Termination Reason in Detailed Description.
Summary
Brief summary (as posted)
To assess the efficacy and safety of PF-3512676 administered in combination with pemetrexed for the treatment of patients with locally advanced or metastatic NSCLC who have failed one prior chemotherapy regimen
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Carcinoma, Non-Small Cell Lung | Lung Non-Small Cell Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| pemetrexed | Drug | Pemetrexed | ALIAS |
| pemetrexed + PF-3512676 | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- B
- description
- Standard of care chemotherapy
- interventionNames
- Drug: pemetrexed
- type
- EXPERIMENTAL
- label
- A
- description
- Standard of care chemotherapy plus experimental intervention (PF-3512676)
- interventionNames
- Drug: pemetrexed + PF-3512676
Primary outcomes (1)
- measure
- Progression-free survival
- timeFrame
- 110 Events
Secondary outcomes (6)
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Locally advanced or metastatic NSCLC * Measurable disease * ECOG PS 0 or 1 Exclusion Criteria: * Known CNS metastasis * Pre-existing autoimmune or antibody mediated disease
References
Publications (0)
Data not yet available