A Study of Sunitinib in Combination With Bevacizumab and Paclitaxel in Previously Untreated Patients With Metastatic Breast Cancer (SABRE-B)

Inclusion Criteria:

* Signed Informed Consent Form
* Histologically or cytologically confirmed adenocarcinoma of the breast with measurable or non-measurable locally recurrent or metastatic disease
* Age ≥ 18 years
* Adequate left ventricular function at study entry, defined as an Left Ventricular Ejection Fraction (LVEF) \> 50% by either Multi Gated Acquisition(MUGA) scan or Electrocardiogram (ECHO)
* Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
* Ability and willingness to comply with study and follow-up procedures

Exclusion Criteria:

* Unknown HER2 status or known HER2-positive status
* Prior chemotherapy for locally recurrent or metastatic disease
* Prior hormonal therapy within 2 weeks prior to Day 1
* Prior adjuvant or neoadjuvant taxane chemotherapy within 12 months prior to Day 1
* Prior adjuvant or neoadjuvant non-taxane chemotherapy within 6 months prior to Day 1
* For patients who have received recent radiotherapy, ongoing Grade ≥ 3 acute toxicity
* Patients with brain metastasis on full dose anticoagulation therapy
* Life expectancy of \< 12 weeks
* Current, recent (within 4 weeks of Day 1), or planned participation in an experimental drug study
* Inadequate organ function within 28 days prior to Day 1
* Untreated abnormal thyroid function tests
* Uncontrolled serious medical or psychiatric illness
* Active infection requiring IV antibiotics at enrollment or randomization
* History of other malignancies within 5 years prior to Day 1 except for tumors with a negligible risk for metastasis or death, such as adequately controlled basal cell carcinoma or squamous-cell carcinoma of the skin or carcinoma in situ of the cervix
* Inadequately controlled hypertension
* Prior history of hypertensive crisis or hypertensive encephalopathy
* New York Heart Association (NYHA) Class II or greater CHF
* History of myocardial infarction or unstable angina within 12 months prior to Day 1
* History of stroke or transient ischemic attack within 12 months prior to Day 1
* Known central nervous system (CNS) disease except for treated brain metastasis
* Significant vascular disease (e.g., aortic aneurysm, aortic dissection) or recent peripheral arterial thrombosis within 6 months prior to Day 1
* History of hemoptysis within 1 month prior to Day 1
* Evidence of bleeding diathesis or significant coagulopathy (in the absence of therapeutic anticoagulation)
* Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to Day 1 or anticipation of need for major surgical procedure during the course of the study
* Core biopsy or other minor surgical procedure, excluding placement of a vascular access device, within 7 days prior to Day 1
* History of abdominal fistula or gastrointestinal perforation within 6 months prior to Day 1
* Serious, non-healing wound, active ulcer, or untreated bone fracture
* Proteinuria at screening, as demonstrated by a urine protein/creatinine ratio of ≥ 1.0 at screening
* Known hypersensitivity to any component of bevacizumab or sunitinib
* Pregnancy (positive pregnancy test) or lactation