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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
12,388 stopped studies mapped to Malignant Neoplasm and descendants · 89% state a reason
Over the 12,388 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00847067 | Chronic Post Breast Surgery Pain | N/A | terminated | Feb 19, 2009 | Mayo Clinic | Funding not renewed | Funding |
| NCT00006261 | Allogeneic Transplantation Using Mini-Conditioning for Treatment of Stage IV Breast Cancer | Phase 2 | withdrawn | Apr 29, 2004 | Case Comprehensive Cancer Center | not stated | Not stated |
| NCT00312442 | Phase II/III Study of WST09 in Prostate Cancer After Radiation Therapy | Phase 2 / Phase 3 | terminated | Apr 10, 2006 | STEBA France | STEBA decided to develop WST11 that is soluble in aqueous solutions. The property of WST 11 make it… | Other (stated, no rule matched) |
| NCT00209729 | Phase I/II Study of Oral S-1 Plus Docetaxel in Elderly Patients With Advanced Gastric… | Phase 1 / Phase 2 | suspended | Sep 21, 2005 | Hokkaido Gastrointestinal Cancer Study Group | Registration is less | Other (stated, no rule matched) |
| NCT00568529 | Combination of Capecitabine and Oxaliplatin in Patients With Relapsed or Refractory… | Phase 2 | suspended | Dec 6, 2007 | Fudan University | There are not enough patients enrolled. | Enrollment / accrual |
| NCT00630292 | Feasibility Study of Vessel Analysis for Noninvasive Diagnosis of Malignancy in Breast… | N/A | terminated | Mar 7, 2008 | University of North Carolina, Chapel Hill | Existing vessel analysis software could not be applied to breast MRI data. | Other (stated, no rule matched) |
| NCT00472706 | Trial of Excision Versus Photodynamic Therapy in the Treatment of Bowen's Disease | Phase 4 | terminated | May 14, 2007 | Catharina Ziekenhuis Eindhoven | Study stopped because of disappointing inclusion rates | Other (stated, no rule matched) |
| NCT00275262 | A Study to Evaluate the Ability of Lupron Depot to Enhance Immune Function Following Bone… | Phase 2 | terminated | Jan 11, 2006 | Abbott | not stated | Not stated |
| NCT00892268 | Acupuncture or Medication in Reducing Pain in Postmenopausal Women With Breast Cancer and… | Phase 2 | terminated | May 4, 2009 | University of Arizona | Poor accural | Other (stated, no rule matched) |
| NCT00258765 | Adjuvant Docetaxel-Zoledronic Acid in High-risk Early Prostate Cancer Following… | Phase 2 | terminated | Nov 28, 2005 | Novartis Pharmaceuticals | Poor recruitment \& not feasible to continue | Enrollment / accrual |
| NCT00298467 | MDX-060 in Patients With Relapsed or Refractory Classic Systemic or Primary Cutaneous… | Phase 2 | withdrawn | Mar 2, 2006 | Bristol-Myers Squibb | sponsor decision | Sponsor / business decision |
| NCT00280007 | Transarterial Chemoembolisation Plus Bevacizumab for Treatment of Hepatocellular Carcinoma | Phase 2 | terminated | Jan 20, 2006 | Medical University of Vienna | Safety concerns in the treatment arm | Safety / toxicity |
| NCT00082212 | A Study in Patients With Persistent or Recurrent Epithelial Ovarian or Primary Peritoneal… | Phase 2 | terminated | May 5, 2004 | Eli Lilly and Company | Due to lack of sufficient efficacy. | Efficacy / futility |
| NCT00171847 | Study of the Efficacy and Safety of Letrozole Combined With Trastuzumab in Patients With…(eLEcTRA) | Phase 4 | terminated | Sep 15, 2005 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00646165 | Trial of Forodesine in Patients With Relapsed B-cell Chronic Lymphocytic Leukemia | Phase 1 | terminated | Mar 28, 2008 | Mundipharma Research Limited | Poor recruitment and change in development strategy | Enrollment / accrual |
| NCT00394615 | Metabolic Imaging Predict Histopathologic Response to Preop ChemoXRT for Locally Advanced… | N/A | terminated | Nov 1, 2006 | Stanford University | Protocol approval expired | Other (stated, no rule matched) |
| NCT01088334 | Mortality Due to Malignancy in Patients With Idiopathic Venous Thromboembolism(Trousseau) | — | terminated | Mar 17, 2010 | Slotervaart Hospital | Terminated because of futility to continue, after planned interim analysis. | Efficacy / futility |
| NCT00201344 | A Phase III Study of Radiotherapy With or Without Adjuvant C/T in Advanced Stage… | Phase 3 | terminated | Sep 20, 2005 | National Health Research Institutes, Taiwan | not stated | Not stated |
| NCT00319930 | Phase 1, Dose-Escalation, Pharmacodynamic Study of IV CNF1010 in ZAP-70 Positive CLL | Phase 1 | terminated | Apr 27, 2006 | Biogen | Discontinuation of program | Other (stated, no rule matched) |
| NCT00036621 | A Randomized, Placebo-Controlled Trial of BMS-275291 Given Daily for 12 Months to Women… | Phase 2 | terminated | May 13, 2002 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00099879 | Study of BMS-275183 in Patients With Pre-treated Non-small Cell Lung Cancer | Phase 2 | terminated | Dec 22, 2004 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00326131 | A Phase I Study of a Single Dose of Radio-labeled BMS-275183 in Patients With Advanced… | Phase 1 | terminated | May 16, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00332748 | A Phase I Study of BMS-275183 (Oral Taxane) Given on a Daily Schedule in Combination With… | Phase 1 | terminated | Jun 2, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00359450 | Study of BMS-275183 in Patients With Pretreated Locally Advanced or Metastatic NSCLC (Non… | Phase 2 | terminated | Aug 2, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00359476 | A Study of Vinflunine in Patients With Gastric Cancer | Phase 2 / Phase 3 | terminated | Aug 2, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00918450 | Study Assessing the Safety and Efficacy of ABT-263 in Subjects With B-cell Chronic… | Phase 2 | withdrawn | Jun 11, 2009 | Abbott | Sponsor has decided to not proceed with this study. | Other (stated, no rule matched) |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00277290 | Study of XL999 in Patients With Previously Treated Ovarian Cancer | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT00277303 | Study of XL999 in Patients With Metastatic Colorectal Cancer | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT00277329 | Study of XL999 in Patients With Non-small Cell Lung Cancer | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subejcts | Safety / toxicity |
| NCT00304590 | Study of XL999 in Patients With Multiple Myeloma | Phase 2 | terminated | Mar 20, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT00322673 | Study of XL999 in Patients With Acute Myeloid Leukemia (AML) | Phase 2 | terminated | May 8, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities | Safety / toxicity |
| NCT00277316 | Study of XL999 in Patients With Metastatic Renal Cell Carcinoma | Phase 2 | terminated | Jan 16, 2006 | Symphony Evolution, Inc. | Development of XL999 was stopped due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT00491699 | Safety Study of XL999 in Adults With Non-Small-Cell Lung Cancer | Phase 1 | terminated | Jun 26, 2007 | Symphony Evolution, Inc. | The study was stopped due to safety concerns | Safety / toxicity |
| NCT00532454 | Evaluation of the Association Between CYP2D6 Genetic Polymorphisms and the Treatment… | Phase 2 | terminated | Sep 20, 2007 | National Cancer Center, Korea | planned to design a prospective study | Other (stated, no rule matched) |
| NCT00540735 | Efficiency Evaluation of Photodynamic Therapy With Photofrin® on Unresectable Type III or…(CK/PDT) | Phase 3 | terminated | Oct 8, 2007 | University Hospital, Angers | Big difficulties to enroll patients | Enrollment / accrual |
| NCT01000896 | Study to Assess Safety and Tolerability of AZD0530 in Combination With Carboplatin and… | Phase 1 | withdrawn | Oct 23, 2009 | AstraZeneca | AstraZeneca has discontinued the development of AZD0530. No new AstraZeneca-sponsored clinical… | Other (stated, no rule matched) |
| NCT00080509 | Effectiveness of KOS-862 in the Treatment of Lung Cancer | Phase 2 | terminated | Apr 7, 2004 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00627627 | A Study to Evaluate the Antitumor Activity and Safety of IPI-504 in Patients With… | Phase 1 / Phase 2 | withdrawn | Mar 3, 2008 | MedImmune LLC | Redirect focus of the indication | Other (stated, no rule matched) |
| NCT00473486 | Study in Patients With Advanced Non-Small Cell Lung Cancer Treated With Pemetrexed and…(PECASO) | Phase 1 / Phase 2 | terminated | May 15, 2007 | University Hospital Muenster | Sorafenib administered in the combination with pemetrexed-carboplatin appears to enhance… | Other (stated, no rule matched) |
| NCT00568971 | Study of Weekly DCF to Treat Advanced Gastric Cancer | Phase 2 | terminated | Dec 6, 2007 | Fudan University | The study has finished. | Other (stated, no rule matched) |
| NCT00004058 | 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone… | Phase 1 | terminated | Jan 27, 2003 | University of Medicine and Dentistry of New Jersey | At this time it is felt that we will not gain further information from an additional patients. | Other (stated, no rule matched) |
| NCT00251186 | First-Line Capecitabine and Cetuximab for Metastatic Colorectal Ca in Elderly Patients | Phase 2 | terminated | Nov 9, 2005 | University of Medicine and Dentistry of New Jersey | Funding unavailable | Funding |
| NCT00378573 | Multicenter Evaluation of Docetaxel, Gemcitabine, and Bevacizumab Combination Followed by… | Phase 2 | terminated | Sep 20, 2006 | Sanofi | Incidence of GI Perforation | Other (stated, no rule matched) |
| NCT00264134 | Docetaxel, Irinotecan, and Carboplatin in Extensive Stage Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | terminated | Dec 12, 2005 | Kentuckiana Cancer Institute | not stated | Not stated |
| NCT00283530 | Tumor Phenotypes and Correlation to Clinical Outcomes in Cancer | — | terminated | Jan 30, 2006 | Kentuckiana Cancer Institute | The PI is no longer with Kentuckiana Cancer Institute. All current subjects completed. No further… | Enrollment / accrual |
| NCT00185874 | Phase I Intratumoral Dendritic Cell Immunotherapy in Thermally Ablated Liver Metastases | Phase 1 | terminated | Sep 16, 2005 | Stanford University | Study closed due to lack of funding | Funding |
| NCT00243490 | Photodynamic Therapy in the Treatment of Malignant Intracranial Tumors | Phase 2 | withdrawn | Oct 24, 2005 | National Taiwan University Hospital | The Trial could not get permit from Department of Health, Taiwan; Furthermore, no research fund… | Funding |
| NCT00730262 | Efficacy Study of TLN-4601 in Patients With Recurring Glioblastoma Multiforme | Phase 2 | terminated | Aug 8, 2008 | Thallion Pharmaceuticals | Lack of efficacy | Efficacy / futility |
| NCT00677287 | Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 14, 2008 | Tokyo University | Lack of financial support | Funding |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jun 11, 2010source: clinicaltrials