Study Assessing the Safety and Efficacy of ABT-263 in Subjects With B-cell Chronic Lymphocytic Leukemia (CLL) Who Have Failed at Least One Prior Fludarabine-containing Regimen

Inclusion Criteria:

* \>= 18 yrs of age, have B-cell CLL, failed at least 1 prior fludarabine-containing regimen.
* Refractory to 1 fludarabine-containing regimen is defined as failure to achieve at least PR to the last fludarabine-containing regimen received, or disease progression while receiving the last fludarabine-containing regimen, or disease progression in responders (i.e., achieved a PR or CR) within 6 mos of the last cycle of the last fludarabine-containing regimen received (e.g., fludarabine monotherapy, FR, or FC) or in responders (i.e., achieved a PR or CR ) within 24 mos of the last cycle of FCR.
* Intolerant to fludarabine is defined as discontinuation of therapy within 2 cycles due to side effects/toxicity from the last fludarabine-containing regimen.
* ECOG score of \<=1.
* Adequate coagulation, renal, \& hepatic function at Screening as follows:

  * Serum creatinine \<= 2.0 mg/dL or calculated creatinine clearance \>= 50 mL/min;
  * AST \& ALT \<= 3.0 x ULN;
  * Bilirubin \<= 1.5 x ULN.
* Gilbert's Syndrome may have a Bilirubin \> 1.5 x ULN; aPTT, PT, not to exceed 1.2 x ULN.
* Adequate bone marrow (BM) independent of any growth factor support (with the exception of subjects with BM heavily infiltrated with underlying disease \[80% or more\] who may use growth factor support to achieve adequate BM) at Screening as follows:

  * ANC \>= 1000/µL;
  * Platelets \>= 75,000/mm3 (entry platelet count must be independent of transfusion within 14 days of Screening);
  * Hemoglobin \>= 9.0 g/dL.
* History of autologous BM transplant must be \> 6 mos post transplant (prior to the 1st dose of study drug) \& have adequate BM independent of any growth factor support (with the exception of subjects with BM that is heavily infiltrated with underlying disease \[80% or more\] who may use growth factor support to achieve adequate BM) at Screening as follows:

  * ANC \>= 1500/µL;
  * Platelets \>= 125,000/mm3;
  * Hemoglobin \>= 10.0 g/dL.
* Female subjects must be surgically sterile, postmenopausal (at least 1 year), or have negative results on a pregnancy test.
* All female subjects not surgically sterile or postmenopausal (at least 1 year) \& non-vasectomized male subjects must practice birth control.

Exclusion Criteria:

* History/clinically suspicious for cancer-related CNS disease.
* Undergone allogeneic stem cell transplant.
* Undergone autologous stem cell transplant w/i 6 mos prior to 1st dose.
* History/predisposing condition of bleeding or currently exhibits signs of bleeding.
* Recent history of non-chemotherapy induced thrombocytopenic associated bleeding w/i 6 mos prior to 1st dose.
* Active peptic ulcer disease or other hemorrhagic esophagitis/gastritis.
* Active immune thrombocytopenic purpura or history of being refractory to platelet transfusions w/i 1 yr prior to 1st dose.
* Currently receiving/requires anticoagulation therapy or any drugs or herbal supplements that affect platelet function, with the exception of low-dose anticoagulation medications used to maintain the patency of a central IV catheter.
* Significant history of cardiovascular disease, renal, neurologic, psychiatric, endocrinologic, metabolic, immunologic, or hepatic disease.
* Positive for HIV, Hepatitis B, or Hepatitis C.
* Previous or current malignancies w/i the last 3 yrs:

  * except adequately treated in situ carcinoma of the cervix uteri;
  * basal or squamous cell carcinoma;
  * in situ carcinoma of the bladder;
  * or previous malignancy confined and surgically resected with curative intent.
* Has Prolymphocytic leukemia or Richter's transformation to an aggressive B-cell malignancy.
* Exhibits evidence of other clinically significant uncontrolled condition(s) including, but not limited to uncontrolled systemic infection or diagnosis of fever and neutropenia w/i 1 week prior to study drug.
* Prior exposure to ABT-263.
* Received antibody therapy w/i 30 days prior to 1st dose.
* Received any anti-cancer therapy including chemotherapy, immunotherapy, radiotherapy, hormonal, or any investigational therapy w/i 14 days prior to the 1st dose, or has not recovered to \<Gr2 clinically significant AE(s) /toxicity(s) of the previous therapy.
* Received steroid therapy for anti-neoplastic intent, w/i 7 days prior to the 1st dose with the exception of inhaled steroids for asthma, topical steroids, or replacement/stress corticosteroids.
* Received aspirin w/i 7 days prior to the 1st dose.
* Consumed grapefruit or grapefruit products w/i 3 days prior to 1st dose.
* Females pregnant or breast-feeding.