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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
204 stopped studies mapped to Malignant Neck Neoplasm and descendants · 91% state a reason
Over the 204 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computed
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02946918 | Levothyroxine Replacement With Liquid Gel Capsules vs Tablets Post-thyroidectomy | Phase 4 | terminated | Oct 27, 2016 | University of Texas Southwestern Medical Center | Terminating study as sponsor has sold the drug to another company | Sponsor / business decision |
| NCT00011492 | Patient Evaluation for Head and Neck Surgery Branch Studies | — | terminated | Feb 23, 2001 | National Institute on Deafness and Other Communication Disorders (NIDCD) | Closed by Sponsor/Data Safety monitoring Board/IRB | Safety / toxicity |
| NCT03479463 | Use of Human Dehydrated Amnion Chorion Allograft in Laryngectomy/Pharyngectomy | — | terminated | Mar 27, 2018 | MiMedx Group, Inc. | Slow enrollment | Enrollment / accrual |
| NCT04231864 | Durvalumab and Epacadostat for Treatment of Unresectable, Recurrent, or Metastatic… | Phase 2 | withdrawn | Jan 18, 2020 | Alain Algazi | Feasibility | Other (stated, no rule matched) |
| NCT02012231 | Phase I/IIa Study to Evaluate the Safety, PK, PD, and Preliminary Efficacy of PLX8394 in… | Phase 1 | terminated | Dec 16, 2013 | Fore Biotherapeutics | not stated | Not stated |
| NCT02709889 | Rovalpituzumab Tesirine in Delta-Like Protein 3-Expressing Advanced Solid Tumors | Phase 1 / Phase 2 | terminated | Mar 16, 2016 | AbbVie | Strategic considerations | Sponsor / business decision |
| NCT00603941 | A Phase 1/2 Study of CS7017, an Oral PPARγ Agonist, in Combination With Paclitaxel | Phase 1 / Phase 2 | terminated | Jan 29, 2008 | Daiichi Sankyo | Due to low enrollment, no participant had a dose limiting toxicity, therefore a maximum tolerated… | Safety / toxicity |
| NCT04106843 | Radioactive Drug (177Lu-DOTATATE) for the Treatment of Locally Advanced, Metastatic, or… | Phase 2 | withdrawn | Sep 27, 2019 | M.D. Anderson Cancer Center | No Participants Registered | Other (stated, no rule matched) |
| NCT02464137 | HYpofractionateD RadioAblative (HYDRA) Treatment of Advanced Laryngeal Cancer(HYDRA) | Phase 1 | terminated | Jun 8, 2015 | University of Texas Southwestern Medical Center | unexpected toxicities | Safety / toxicity |
| NCT01249443 | Paclitaxel and Carboplatin in Treating Patients With Metastatic or Recurrent Solid Tumors… | Phase 1 | terminated | Nov 29, 2010 | AIDS Malignancy Consortium | Inadequate accrual rate | Enrollment / accrual |
| NCT00181220 | Valproic Acid in the Induction of EBV Lytic Cycle Antigen Expression in Nasopharyngeal… | Phase 1 | withdrawn | Sep 16, 2005 | Johns Hopkins University | PI left JHU and is not able to be reached for updates | Investigator |
| NCT00367718 | Trial of VELCADE in Patients With Metastatic or Locally Recurrent Nasopharyngeal Carcinoma | Phase 2 | withdrawn | Aug 23, 2006 | Johns Hopkins University | PI left JHU and is not able to be reached for updates | Investigator |
| NCT01192815 | Erlotinib Hydrochloride and Radiation Therapy in Stage III-IV Squamous Cell Cancer of the… | Phase 2 | terminated | Sep 1, 2010 | Case Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT02236936 | Parenteral Nutrition for Patients Treated for Locally Advanced Inoperable Tumors of the…(AGMT_HNO_PN) | Phase 3 | terminated | Sep 11, 2014 | Arbeitsgemeinschaft medikamentoese Tumortherapie | Study stopped due to low recruitment | Enrollment / accrual |
| NCT01265381 | Thyroid Cancer Among Chornobyl Clean-up Workers in Ukraine: Pilot Study | — | terminated | Dec 23, 2010 | National Cancer Institute (NCI) | This protocol was determined to be not human subjects research. | Other (stated, no rule matched) |
| NCT02569788 | Trail Evaluating Carbon Ion Radiotherapy for Locally Recurrent Nasopharyngeal Carcinoma | Phase 1 / Phase 2 | terminated | Oct 7, 2015 | Shanghai Proton and Heavy Ion Center | Slow accrual of patients. | Enrollment / accrual |
| NCT02801487 | Trial Evaluating Carbon Ion Radiotherapy With Concurrent Chemotherapy for Locally… | Phase 1 / Phase 2 | terminated | Jun 15, 2016 | Shanghai Proton and Heavy Ion Center | Slow accrual of patients. | Enrollment / accrual |
| NCT02390739 | Administering Peripheral Blood Lymphocytes Transduced With a Murine T-Cell Receptor… | Phase 1 / Phase 2 | withdrawn | Mar 18, 2015 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00582712 | An Initial Study of Lithium in Patients With Medullary Thyroid Cancer | Phase 2 | terminated | Dec 28, 2007 | University of Wisconsin, Madison | Budget/Funding | Funding |
| NCT01974284 | Percutaneous Ethanol Injection for Primary Papillary Thyroid Microcarcinoma | N/A | terminated | Nov 1, 2013 | Yale University | Lack of patient enrollment | Enrollment / accrual |
| NCT01883908 | Acupuncture in Reducing the Severity of Chemoradiation-induced Mucositis in Patients With…(GCC1229) | N/A | terminated | Jun 21, 2013 | University of Maryland, Baltimore | The project is terminated due to that fact that the PI has moved to another institution and there… | Other (stated, no rule matched) |
| NCT02657369 | A Phase 2 Trial of Lenvatinib for the Treatment of Anaplastic Thyroid Cancer (ATC) | Phase 2 | terminated | Jan 15, 2016 | Eisai Inc. | Overall response rate was 3% (only 1 out of 33 participants had confirmed PR). | Other (stated, no rule matched) |
| NCT01230476 | Induction and Concurrent Chemoradiotherapy With Cetuximab for Patients With Locally… | Phase 2 | terminated | Oct 29, 2010 | University of Malaya | not stated | Not stated |
| NCT02062632 | Doxepin Hydrochloride in Treating Esophageal Pain in Patients With Thoracic Cancer… | Phase 2 | terminated | Feb 14, 2014 | Mayo Clinic | Poor accrual | Enrollment / accrual |
| NCT02789189 | Nedaplatin Combined With Gemcitabine in the Treatment of Recurrent and/or Metastatic… | Phase 2 | terminated | Jun 2, 2016 | Sun Yat-sen University | not stated | Not stated |
| NCT03575234 | Nivolumab & IRX-2 With Surgery for Resectable Stage III-IVA Oral Cavity Cancer or… | Phase 1 | withdrawn | Jul 2, 2018 | Emory University | funding and drug were withdrawn | Funding |
| NCT03611205 | Interim Digital PET/CT in Predicting Outcomes for Participants With Locally Advanced… | N/A | withdrawn | Aug 2, 2018 | Ohio State University Comprehensive Cancer Center | PI decision | Other (stated, no rule matched) |
| NCT02289144 | Ceritinib in Mutation and Oncogene Directed Therapy in Thyroid Cancer | Phase 2 | withdrawn | Nov 13, 2014 | University of Texas Southwestern Medical Center | study was on hold for protocol redesign; decided to not move forward with study. | Other (stated, no rule matched) |
| NCT02137096 | Autologous Stem Cell Transplantation for Patients With Recurrent Nasopharyngeal Carcinoma | Phase 3 | terminated | May 13, 2014 | University of Florida | This is a rare disease, and enrollment was poor. | Enrollment / accrual |
| NCT02706691 | BGJ398 in Treating Patients With FGFR Positive Recurrent Head and Neck Cancer | Phase 2 | terminated | Mar 11, 2016 | University of Chicago | Study stopped due to poor enrollment. | Enrollment / accrual |
| NCT02472080 | Gemcitabine - Oxaliplatin for Advanced Refractory Thyroid Cancer Patients: a Phase II…(THYGEMOX) | Phase 2 | terminated | Jun 15, 2015 | Assistance Publique - Hôpitaux de Paris | inefficiency | Other (stated, no rule matched) |
| NCT00484601 | Ifosfamide and Doxorubicin in Patients With Refractory Nasopharyngeal Carcinoma | Phase 2 | terminated | Jun 11, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low accrual. | Enrollment / accrual |
| NCT03049358 | Olfactory Training in Improving Sense of Smell After Radiation Therapy in Patients With… | N/A | terminated | Feb 10, 2017 | Stanford University | Accrual factor | Enrollment / accrual |
| NCT02388932 | Stereotactic Body Radiation Therapy in Treating Patients With High Risk Locally Advanced… | N/A | terminated | Mar 17, 2015 | Case Comprehensive Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00828386 | Induction Chemotherapy and Chemoradiotherapy in Nasopharyngeal Cancers(NPC2006) | Phase 3 | terminated | Jan 23, 2009 | Groupe Oncologie Radiotherapie Tete et Cou | Low accrual | Enrollment / accrual |
| NCT00923247 | A Targeted Phase I/II Trial of ZD6474 (Vandetanib; ZACTIMA) Plus the Proteasome… | Phase 1 / Phase 2 | terminated | Jun 18, 2009 | National Cancer Institute (NCI) | Terminated due to slow accrual,primary endpoint reached \& investigator left NIH. | Investigator |
| NCT00926978 | Comparison of Iodine-124 (I-124) and Iodine-131 (I-131) Radiopharmacokinetics in Patients… | N/A | terminated | Jun 24, 2009 | Medstar Health Research Institute | Institutional RDRC dissolved | Other (stated, no rule matched) |
| NCT02947399 | Comparison of I-124 and I-131 Radiopharmacokinetics in DTC Patients With Thyroid Hormone… | N/A | terminated | Oct 27, 2016 | Medstar Health Research Institute | Institutional RDRC dissolved | Other (stated, no rule matched) |
| NCT00804830 | Avastin and Doxorubicin Postoperatively for Patients With Anaplastic Thyroid Cancer | Phase 2 | terminated | Dec 9, 2008 | Region Skane | lack of response | Other (stated, no rule matched) |
| NCT01053546 | Effects of Swallowing Exercises on Patients Undergoing Radiation Treatment for Head and… | N/A | terminated | Jan 21, 2010 | Wake Forest University Health Sciences | slow accrual | Enrollment / accrual |
| NCT01164566 | Esophagoscopy in Evaluating Treatment in Patients With Stage I-IV Head and Neck Cancer… | N/A | terminated | Jul 16, 2010 | Wake Forest University Health Sciences | Inadequate Recruitment | Enrollment / accrual |
| NCT02552550 | Swallowing, Speech and Quality of Life of Patients With Carcinoma of the Oropharynx | — | terminated | Sep 17, 2015 | Centre Hospitalier Universitaire de Saint Etienne | rate of inclusion too low | Other (stated, no rule matched) |
| NCT00126568 | Sorafenib in Treating Patients With Advanced Anaplastic Thyroid Cancer | Phase 2 | terminated | Aug 4, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02628912 | Cardiopulmonary Fitness in Long-Term Survivors of HPV-related Oropharynx Cancers | — | withdrawn | Dec 11, 2015 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT02225496 | Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma | Phase 2 | terminated | Aug 26, 2014 | M.D. Anderson Cancer Center | Another trial in the department directly competes for the the same patient population | Other (stated, no rule matched) |
| NCT02022293 | Atorvastatin in Preventing Nasopharyngeal Carcinoma Patients Receiving Radiotherapy From… | Phase 2 | suspended | Dec 27, 2013 | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | Enrollment target could not be achieved. | Enrollment / accrual |
| NCT02298595 | Cetuximab, Cisplatin and BYL719 for HPV-Associated Oropharyngeal Squamous Cell Carcinoma | Phase 1 / Phase 2 | withdrawn | Nov 24, 2014 | Julie E. Bauman, MD, MPH | not stated | Not stated |
| NCT02068157 | Interstitial Photodynamic Therapy in Treating Patients With Recurrent Head and Neck Cancer | Phase 2 | terminated | Feb 21, 2014 | Roswell Park Cancer Institute | Study no longer has an active IDE | Other (stated, no rule matched) |
| NCT00965003 | MRI Laryngeal Imaging With a Surface Coil | Early Phase 1 | terminated | Aug 25, 2009 | Stanford University | Absence of key personnel to conduct study | Other (stated, no rule matched) |
| NCT02831179 | Veliparib, Capecitabine, and Temozolomide in Patients With Advanced, Metastatic, and… | Phase 1 | withdrawn | Jul 13, 2016 | Vanderbilt-Ingram Cancer Center | Loss of funding support | Funding |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Dec 1, 2020source: clinicaltrials