Clinical trial · Interventional
MRI Laryngeal Imaging With a Surface Coil
High Resolution MRI in the Evaluation of Laryngeal Neoplasia
NCT00965003CI-TRIAL-00029775terminatedEarly Phase 1ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Absence of key personnel to conduct study
Summary
Brief summary (as posted)
To determine if high resolution MRI can detect early invasion of cartilage by laryngeal carcinoma, and to determine if high resolution MRI may be superior to conventional MRI imaging or CT imaging to detect cartilage invasion.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Head and Neck Cancers | Malignant Head and Neck Neoplasm | ALIAS | 0.90 |
| Laryngeal Neoplasms | Laryngeal Neoplasm | ONTOLOGY_EXACT | 0.98 |
| Larynx Cancer | Malignant Laryngeal Neoplasm | CURATED_BROADER | 0.80 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| MRI scan | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- type
- EXPERIMENTAL
- label
- MRI scan with surface coil
- description
- Patients with known laryngeal cancer, with suspected cartilage involvement by conventional computed tomography scanning, who undergo high resolution magnetic resonance imaging enhanced with a surface coil placed over the larynx.
- interventionNames
- Procedure: MRI scan
Primary outcomes (1)
- measure
- Tumor stage as determined by HRMRI.
- timeFrame
- 24 to 48 hours
- description
- Radiologic tumor stage
Secondary outcomes (2)
- measure
- Estimate the precision of HRMRI in discriminating between edema and tumor in patients with prior radiotherapy or chemotherapy.
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Patients with benign or malignant neoplasm of the larynx. * Patients who have undergone prior surgery, radiation therapy, or chemotherapy for cancer of the laryngopharynx will be eligible to participate. * Patients 18 years of age and older at time of evaluation, male and female, all ethnicities. * Ability to understand and the willingness to sign a written informed consent document. Exclusion Criteria: * Pregnancy * Claustrophobia. * Anatomic parameters which preclude scanning, such as limited range of neck motion, or inability to remain flat for at least 15 minutes. * Patients with implanted devices (eg, defibrillator, pacemaker) that are a known contraindication to magnetic resonance imaging. * Allergy to gadolinium contrast.
References
Publications (0)
Data not yet available
No reference posted for this study.