Olfactory Training in Improving Sense of Smell After Radiation Therapy in Patients With Paranasal Sinus or Nasopharyngeal Cancer

Inclusion Criteria:

* Eligible disease(s)/stage(s): nasopharyngeal carcinoma, paranasal sinus cancers/any stage
* Patients with paranasal sinus or nasopharyngeal carcinoma who are about to undergo radiation therapy; patients with paranasal sinus or nasopharyngeal carcinoma who have completed radiation therapy 3-6 months prior to enrollment who then show olfactory loss on a screening test (University of Pennsylvania Smell Identification Test \[UPSIT\] - score of 34 or 33 or lower out of 40, depending on female/male); both those patients undergoing chemotherapy and those who did not will be eligible, and this factor will be assessed as a possible confounder/contributor in a multi-regression analysis
* No race-ethnic restriction
* No life expectancy restriction
* No need for Karnofsky performance status
* Only requirement for organ function is for patients to have competency to consent and participate in the study; in the arm of the study which requires patients to have olfactory dysfunction before enrollment, an UPSIT score will be used to identify these patients
* Ability to understand and the willingness to sign a written informed consent document

Exclusion Criteria:

* No therapy restrictions
* No restrictions on use of other investigational agents
* Co-morbid disease or incurrent illness such as:

  * History of head trauma
  * History of nasal surgery other than biopsy (before cancer was diagnosed)
  * History of sinus surgery other than biopsy (before cancer was diagnosed)
  * Chronic rhinosinusitis with or without polyp
  * Pregnancy
  * Cognitive dysfunction
  * History of brain surgery
  * Psychiatric or neurologic diseases interfering with sense of smell
  * Congenital disorders of olfactory dysfunction
  * Olfactory loss prior to onset of nasopharyngeal carcinoma
* No allergic reactivity has been associated with olfactory training and thus there is no need for any exclusion criteria related to this
* No other agents have any possible potentiation or decreased activity related to olfactory training and thus there is no need for any exclusion criteria related to this
* There are no other agent-specific exclusion criteria
* Pregnant women will be excluded; nursing patients will be included