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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
876 stopped studies mapped to Malignant Male Reproductive System Neoplasm and descendants · 91% state a reason
Over the 876 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00332280 | Study to Evaluate the Clinical Benefit Response in Cancer Patients With Advanced Disease… | Phase 2 / Phase 3 | terminated | Jun 1, 2006 | Auron Healthcare GmbH | Lack of efficacy. Stopped at first interim evaluation point | Efficacy / futility |
| NCT01478308 | Metformin With Standard Taxotere and Prednisone in the Treatment of Castration Resistant… | Phase 2 | withdrawn | Nov 23, 2011 | New Mexico Cancer Research Alliance | No accrual in initial period, PI decided to close study. | Enrollment / accrual |
| NCT00559481 | Ketoconazole, Dexamethasone, and Hydrocortisone in Treating Patients With Prostate Cancer… | N/A | withdrawn | Nov 16, 2007 | Roswell Park Cancer Institute | Withdrawn due to low accrual | Enrollment / accrual |
| NCT00383487 | A Phase II Trial of Calcitriol and Naproxen in Patients With Recurrent Prostate Cancer | Phase 2 | terminated | Oct 3, 2006 | Stanford University | Extreme toxicity | Safety / toxicity |
| NCT00005039 | Vaccine Therapy in Treating Patients With Advanced Adenocarcinoma of the Prostate… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00042952 | Imatinib Mesylate in Treating Patients With Progressive, Refractory, or Recurrent Stage… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00005067 | Photodynamic Therapy With Lutetium Texaphyrin in Treating Patients With Locally Recurrent… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00512668 | Hormone Therapy and Temsirolimus in Treating Patients With Relapsed Prostate Cancer | Phase 1 | terminated | Aug 8, 2007 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00288444 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | Phase 1 | terminated | Feb 8, 2006 | Emory University | not stated | Not stated |
| NCT01226888 | Changes in Brown Adipose Tissue Activity In Men Receiving Androgen Deprivation Therapy… | — | terminated | Oct 22, 2010 | Massachusetts General Hospital | Slow accrual | Enrollment / accrual |
| NCT00919022 | Androcur Non-interventional Study Among Patients With Carcinoma of the Prostate(ANES) | — | terminated | Jun 11, 2009 | Bayer | not stated | Not stated |
| NCT00714376 | Phase II Study of Docetaxel for Clinically Asymptomatic High Risk Prostate Cancer Patients(TAX1) | Phase 2 | terminated | Jul 14, 2008 | CHU de Quebec-Universite Laval | Prematurely terminated due to financial considerations | Funding |
| NCT00293371 | Docetaxel, Prednisone, and Vatalanib in Treating Patients With Advanced Prostate Cancer | Phase 1 / Phase 2 | terminated | Feb 17, 2006 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00313534 | Nordihydroguaiaretic Acid in Treating Patients With Nonmetastatic Relapsed Prostate Cancer | Phase 1 | terminated | Apr 12, 2006 | University of California, San Francisco | Ran out of drug | Other (stated, no rule matched) |
| NCT00379119 | Effect of Androgen Blockade Therapy on Thymus Function in Older Patients Who Have… | — | terminated | Sep 21, 2006 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00006371 | A Phase II Trial of Early Medical Adrenalectomy for "D0.5" Prostate Cancer | Phase 2 | terminated | Apr 2, 2004 | H. Lee Moffitt Cancer Center and Research Institute | low accrual | Enrollment / accrual |
| NCT00014586 | Bicalutamide Compared With Observation Followed by Bicalutamide Plus Either Goserelin or… | Phase 3 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT01663415 | A Study to Evaluate the Safety and Efficacy of Enzalutamide in Chemotherapy-Naïve,… | Phase 2 | withdrawn | Aug 13, 2012 | Astellas Pharma Global Development, Inc. | A business decision was made to not initiate this study. | Sponsor / business decision |
| NCT00626548 | A Phase III Trial of ZD4054 (Zibotentan) (Endothelin A Antagonist) in Non-metastatic…(ENTHUSE M0) | Phase 3 | terminated | Feb 29, 2008 | AstraZeneca | early efficacy review by the Independent Data Monitoring Committee indicated it was unlikely to… | Efficacy / futility |
| NCT00450970 | Expanded Access Study of Satraplatin Plus Prednisone in Patients With Hormone Refractory…(SPERA) | Phase 3 | terminated | Mar 22, 2007 | Agennix | Sponsor decided to discontinue study drug development. | Sponsor / business decision |
| NCT00388804 | External Beam Radiation Therapy (EBRT) With or Without Hormonal Therapy in Prostate Cancer | Phase 3 | terminated | Oct 17, 2006 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00147238 | A Validation Study of MR Lymphangiography Using SPIO, a New Lymphotropic… | N/A | terminated | Sep 7, 2005 | M.D. Anderson Cancer Center | Terminated at request of sponsor. | Other (stated, no rule matched) |
| NCT00901420 | Urodynamic Evaluation in Post-radiation Salvage Prostatectomy Patients | — | terminated | May 13, 2009 | M.D. Anderson Cancer Center | Terminated due to slow accrual. | Enrollment / accrual |
| NCT00811031 | Preoperative Docetaxel for Localized Progressive Castration-resistant Prostate Cancer… | Phase 2 | withdrawn | Dec 18, 2008 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00877617 | Quality of Life in Men With High Risk Localized Prostate Cancer | — | withdrawn | Apr 8, 2009 | M.D. Anderson Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00058266 | Genistein in Treating Patients With Localized Prostate Cancer Who Are Planning to Undergo… | Phase 2 | terminated | Apr 9, 2003 | Northwestern University | Data Monitoring Committee cited poor accrual. | Enrollment / accrual |
| NCT00471718 | ABT-751 in Treating Patients With Metastatic Prostate Cancer That Did Not Respond to… | Phase 1 / Phase 2 | terminated | May 10, 2007 | Vanderbilt-Ingram Cancer Center | pharmaceutical company closed study because the treatment was not effective | Sponsor / business decision |
| NCT01558778 | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem… | N/A | withdrawn | Mar 20, 2012 | Roswell Park Cancer Institute | device not available | Other (stated, no rule matched) |
| NCT00127387 | Enbrel Versus Placebo With Radiation Therapy to Combat Fatigue and Cachexia | Phase 2 / Phase 3 | terminated | Aug 5, 2005 | The University of Texas Health Science Center at San Antonio | PI moved to Oregon | Other (stated, no rule matched) |
| NCT00881725 | A Study of Pre-operative Metformin in Prostate Cancer(ANIMATE) | Phase 2 | terminated | Apr 15, 2009 | University Health Network, Toronto | Slow Accrual | Enrollment / accrual |
| NCT00050297 | YM598 in Patients With Rising PSA After Initial Therapy for Localized Prostate Cancer | Phase 2 | terminated | Dec 4, 2002 | Astellas Pharma Inc | not stated | Not stated |
| NCT00242931 | Flu/TBI in Treating Patients Not Responding to Previous Hormone Therapy | Phase 2 | withdrawn | Oct 21, 2005 | OHSU Knight Cancer Institute | Unable to successfully recruit subjects to this study. | Enrollment / accrual |
| NCT00244920 | Hormone Therapy With or Without Squalamine Lactate in Treating Patients Who Are… | Phase 2 | withdrawn | Oct 27, 2005 | OHSU Knight Cancer Institute | Sponsor withdrew drug. | Other (stated, no rule matched) |
| NCT00073970 | Celecoxib in Treating Patients With Relapsed Prostate Cancer Following Radiation Therapy… | Phase 2 | terminated | Dec 11, 2003 | UNC Lineberger Comprehensive Cancer Center | Study stopped due to increased cardiovascular risks associated with Celebrex | Other (stated, no rule matched) |
| NCT00313456 | A Phase I Study of the Oral Platinum Agent Satraplatin in Combination With Weekly… | Phase 1 | terminated | Apr 12, 2006 | Agennix | Sponsor decided to discontinue study drug development | Sponsor / business decision |
| NCT00294437 | ZOMETA® (Zoledronic Acid) for Prevention of Bone Metastases | Phase 3 | terminated | Feb 22, 2006 | Central European Cooperative Oncology Group | underfunding | Other (stated, no rule matched) |
| NCT00911027 | SonoVue Guided Prostate Biopsy | Phase 3 | terminated | Jun 1, 2009 | Bracco Diagnostics, Inc | Failure to meet primary objective | Other (stated, no rule matched) |
| NCT00005827 | Genistein in Treating Patients With Stage II, Stage III, or Stage IV Prostate Cancer | Phase 1 | withdrawn | Apr 20, 2004 | UNC Lineberger Comprehensive Cancer Center | not stated | Not stated |
| NCT00820287 | Identification of Predictive Markers for Testis Cancer in a Population of Men With High… | N/A | terminated | Jan 12, 2009 | Centre Hospitalier Universitaire de Nice | not stated | Not stated |
| NCT00480623 | A Phase I Trial of Satraplatin Plus Radiation Therapy for Prostate Cancer Patients With… | Phase 1 | terminated | May 31, 2007 | Agennix | Sponsor decided to discontinue study drug development | Sponsor / business decision |
| NCT01340599 | Defined Green Tea Catechin Extract in Treating Patients With Localized Prostate Cancer… | Phase 2 | terminated | Apr 22, 2011 | Case Comprehensive Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00773318 | SPECT-CT Guided Lymphatic Mapping and Sentinel Lymphadenectomy (LM/SL) in Prostate Cancer | N/A | terminated | Oct 16, 2008 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | 1 patient has been enrolled. No complications reported. The research team decided to terminate the… | Enrollment / accrual |
| NCT00989105 | Technetium Tc 99m Demobesin-4 for Imaging Procedures in Patients With Prostate Cancer | Phase 1 | terminated | Oct 2, 2009 | Cancer Research UK | not stated | Not stated |
| NCT01132599 | Comparing PET-CT Using C-11 Choline and 18F-Fluoromethylcholine in Patients With… | Phase 2 | withdrawn | May 28, 2010 | Cancer Research UK | not stated | Not stated |
| NCT00585741 | Pilot Study of 18F-FLT PET | N/A | terminated | Jan 3, 2008 | University of Wisconsin, Madison | not stated | Not stated |
| NCT00736164 | Selenomethionine in Treating Patients Undergoing Surgery or Internal Radiation Therapy… | Phase 2 | withdrawn | Aug 15, 2008 | Roswell Park Cancer Institute | No accrual | Enrollment / accrual |
| NCT01132404 | Study in Men With Prostate Cancer to Assess the Safety, Pharmacokinetics and… | Phase 1 / Phase 2 | terminated | May 28, 2010 | Millennium Pharmaceuticals, Inc. | Developing new formulation of study drug. New study to open next year under a new protocol. | Other (stated, no rule matched) |
| NCT01510288 | Phase 1 Trial of Ipilimumab and GVAX in Patients With Metastatic Castration-resistant… | Phase 1 | terminated | Jan 16, 2012 | Amsterdam UMC, location VUmc | The study was terminated because Cell Genesys stopped all activities for GVAX. | Other (stated, no rule matched) |
| NCT00122252 | Biological Imaging for Optimising Clinical Target Volume (CTV) and Gross Tumour Volume… | — | terminated | Jul 22, 2005 | Alberta Health services | Study abandoned. | Other (stated, no rule matched) |
| NCT01153113 | Human Telomerase Reverse Transcriptase Messenger RNA (hTERT mRNA) Transfected Dendritic… | Phase 1 / Phase 2 | withdrawn | Jun 29, 2010 | University of Florida | IND has been withdrawn and the study is closed. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Mar 20, 2013source: clinicaltrials