Changes in Brown Adipose Tissue Activity In Men Receiving Androgen Deprivation Therapy for Prostate Cancer

Androgen deprivation therapy (ADT) is considered standard of care for prostate cancer. However, changes in the patients metabolism are usually seen as a result of hormone therapy. These changes include increased fat mass, decreased lean mass, weight gain, high blood cholesterol, increased incidence of diabetes, and possibly increased incidence of cardiac events such as heart attack. The researchers of this trial would like to learn if these change in body mass are affected by the presence of brown fat in the body. Brown fat is made up of fat cells that are stored in the body and generate heat to control body temperature. Levels of brown fat are at the highest in newborn babies and decrease over time into adulthood. The researchers of this trial would like to learn more about these changes in metabolism during prostate cancer treatment by studying the changes in brown fat during the first 12 months of hormone therapy.

Sex

Male

Inclusion Criteria:

* Adenocarcinoma of the prostate
* Scheduled to initiate GnRH agonist or antagonist treatment with an intended treatment duration of 12 months or greater
* ECOG Performance status of 0 or 1
* Ability to understand and the willingness to sign a written informed consent
* 65 years of age or younger

Exclusion Criteria:

* Diagnosis of diabetes
* Ongoing corticosteroid use
* GnRH agonist or antagonist treatment within the last 2 years
* Ongoing beta-blocker use
* Body mass index of greater than 30