Clinical trial · Interventional
Celecoxib in Treating Patients With Relapsed Prostate Cancer Following Radiation Therapy or Radical Prostatectomy
A Trial Of COX-2 Inhibitors In PSA Recurrence After Definitive Radiation Or Radical Prostatectomy For Prostate Cancer
NCT00073970CI-TRIAL-00006966terminatedPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Study stopped due to increased cardiovascular risks associated with Celebrex
Summary
Brief summary (as posted)
RATIONALE: Celecoxib may stop the growth of cancer by stopping blood flow to the tumor and by blocking the enzymes necessary for tumor cell growth. PURPOSE: Phase II trial to study the effectiveness of celecoxib in treating patients who have relapsed prostate cancer following radiation therapy or radical prostatectomy.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Prostate Cancer | Malignant Prostate Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| celecoxib | Drug | Celecoxib | ALIAS |
Design
Arms and outcomes
Arms (0)
[]Primary outcomes (1)
- measure
- Effect of COX-2 inhibitors on PSA level
- timeFrame
- 9 months
- description
- To study the effect of COX-2 inhibitors on PSA level in patients who have only biochemical relapse after definitive radiation therapy or surgery for prostate cancer. In particular, to study the effect of celecoxib on PSA levels and PSA doubling times as compared to 1) historical controls (known and well-described median PSA doubling times of 9 months), and 2) pre-treatment PSA values and doubling times.
Secondary outcomes (1)
- measure
- Disease progression rate
- timeFrame
- 5 years
- description
- Progression will be defined as evidence of biochemical relapse (increase in serum PSA levels on 3 successive determinations, provided that the increase is at least 5 ng/ml from baseline) or clinical objective progression or relapse - i.e. the development of new lesions by digital rectal exam (DRE) or enlargement of existing lesion, or the development of symptoms of clinical progression (specifically bony pain) which is confirmed by radiological imaging studies
Eligibility
Eligibility (as posted)
- Sex
- Male
- Minimum age
- 18 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Diagnosis of clinically localized adenocarcinoma of the prostate * T1 or T2 disease * Received prior primary treatment with definitive radiotherapy (at least 5,500 cGy) OR radical prostatectomy * Biochemical relapse within 5 years after prior primary therapy, defined as 1 of the following: * Detectable and rising prostate-specific antigen (PSA) after surgery (at least 2 values above the residual cancer detection limit of the assay) * PSA at least 2 values above 1 ng/mL OR at least 3 rising values at any level after radiotherapy * PSA no greater than 10 ng/mL PATIENT CHARACTERISTICS: Age * Not specified Performance status * ECOG 0-2 Life expectancy * Not specified Hematopoietic * Not specified Hepatic * ALT no greater than 2.5 times upper limit of normal Renal * Creatinine normal Other * No allergy to cyclooxygenase-2 inhibitors, aspirin, nonsteroidal anti-inflammatory drugs, or sulfa drugs * No untreated peptic ulcer disease PRIOR CONCURRENT THERAPY: Biologic therapy * Not specified Chemotherapy * No prior chemotherapy Endocrine therapy * More than 6 months since prior adjuvant or neoadjuvant hormonal therapy * Duration of prior adjuvant or neoadjuvant hormonal therapy must have been no more than 6 months Radiotherapy * See Disease Characteristics * Prior salvage radiotherapy after prostatectomy allowed Surgery * See Disease Characteristics
References
Publications (0)
Data not yet available
No reference posted for this study.