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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
848 stopped studies mapped to Malignant Large Intestinal Neoplasm and descendants · 91% state a reason
Over the 848 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00026468 | Exisulind in Preventing Polyps in Patients With Familial Adenomatous Polyposis | Phase 2 / Phase 3 | withdrawn | Jan 27, 2003 | University of Utah | Principle Investigator has left the University. | Investigator |
| NCT00003486 | Antineoplaston Therapy in Treating Patients With Colon Cancer | Phase 2 | withdrawn | Jan 27, 2003 | Burzynski Research Institute | not stated | Not stated |
| NCT00896467 | Psychological and Emotional Impact in Patients Undergoing Treatment For Metastatic Cancer… | — | terminated | May 11, 2009 | Centre Oscar Lambret | not stated | Not stated |
| NCT00932724 | CY-503 for the Treatment of Chemotherapy-refractory Metastatic Colorectal Cancer(CY503C2) | Phase 2 | terminated | Jul 3, 2009 | Cytavis Biopharma GmbH | The sponsor declared the early termination of the study due to poor recruitment of patients. | Enrollment / accrual |
| NCT00049608 | Gemcitabine Combined With Mistletoe in Treating Patients With Advanced Solid Tumors | Phase 1 | terminated | Jan 27, 2003 | National Center for Complementary and Integrative Health (NCCIH) | Principal investigator \[PI\] has left institution. | Investigator |
| NCT00908024 | Combination Study of BMS-754807 and Erbitux® in Subjects With Advanced or Metastatic… | Phase 1 / Phase 2 | terminated | May 25, 2009 | Bristol-Myers Squibb | not stated | Not stated |
| NCT01257035 | Predictive Value of 18F-FAZA in Rectum Cancer(FAZA) | — | terminated | Dec 9, 2010 | Vejle Hospital | The logistics of this trial (incl. supply of tracer) in connection with the patients' treatment… | Drug supply |
| NCT01872104 | Safety and Efficiency of Photodynamic Therapy for Rectal Cancer(PDT-R-01) | Phase 2 / Phase 3 | suspended | Jun 7, 2013 | li xiong | Modifying the clinnicaltrials | Other (stated, no rule matched) |
| NCT01293942 | IXO+A in mCRC With Liver-only Metastases | Phase 2 | withdrawn | Feb 11, 2011 | Ottawa Hospital Research Institute | not stated | Not stated |
| NCT00006001 | SU5416 in Treating Patients With Metastatic or Locally Recurrent Colorectal Cancer | Phase 2 | terminated | May 26, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01032291 | A Study to Assess the Efficacy and Safety of Lenalidomide in Combination With Cetuximab… | Phase 2 | terminated | Dec 15, 2009 | Celgene Corporation | A business decision not to continue with Phase 2b based on non-safety observations during proof of… | Safety / toxicity |
| NCT00012246 | Vaccine Therapy in Treating Patients With Cancer of the Gastrointestinal Tract | Phase 2 | terminated | Jan 27, 2003 | The University of Texas Medical Branch, Galveston | Administratively Terminated | Other (stated, no rule matched) |
| NCT00268463 | Oxaliplatin and Capecitabine With or Without an Hepatic Arterial Infusion With… | Phase 3 | terminated | Dec 22, 2005 | NSABP Foundation Inc | The study was terminated due to low accrual. | Enrollment / accrual |
| NCT01189227 | Combination Chemotherapy Before or After Surgery in Treating Patients With Colorectal… | Phase 3 | terminated | Aug 26, 2010 | NSABP Foundation Inc | The study was terminated due to low accrual. | Enrollment / accrual |
| NCT00006015 | Combination Chemotherapy Plus Trastuzumab in Treating Patients With Advanced, Recurrent,… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | lack of sufficient accrual | Enrollment / accrual |
| NCT00960427 | Studying Biomarkers in Tumor Tissue and Blood Samples From Patients Undergoing… | Phase 1 | withdrawn | Aug 17, 2009 | Barbara Ann Karmanos Cancer Institute | No surgeon available to perfrom gastroscopy | Other (stated, no rule matched) |
| NCT01466504 | Effect of Sorafenib or Regorafenib on P63 Expression and Keratinocyte Differentiation in… | — | terminated | Nov 8, 2011 | Dartmouth-Hitchcock Medical Center | Accrual did not meet expectations. Over nearly 2 years just 4 subjects were treated on study. The… | Enrollment / accrual |
| NCT00004193 | ISIS 2503 in Treating Patients With Metastatic and/or Locally Recurrent Colorectal Cancer | Phase 2 | terminated | Aug 5, 2004 | University of Alabama at Birmingham | not stated | Not stated |
| NCT01329809 | Neoadjuvant Study of Recombinant Vaccinia Virus to Treat Metastatic Colorectal Carcinoma… | Phase 2 | terminated | Apr 6, 2011 | Jennerex Biotherapeutics | not stated | Not stated |
| NCT00016029 | Comparison of Barium Enema, Computed Tomographic Colonography, and Colonoscopy in… | N/A | terminated | Jan 27, 2003 | Duke University | not stated | Not stated |
| NCT00405561 | Study to Evaluate Progression Free Survival in Cancer Patients With Advanced Colorectal… | Phase 2 / Phase 3 | terminated | Nov 30, 2006 | Auron Healthcare GmbH | Lack of efficacy | Efficacy / futility |
| NCT01786538 | Second-line FOLFOX With or Without Regorafenib in mCRC Patients Failed to First-line… | Phase 3 | withdrawn | Feb 8, 2013 | Asan Medical Center | not stated | Not stated |
| NCT00937482 | Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases… | Phase 1 | terminated | Jul 13, 2009 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00608595 | Celecoxib in Treating Patients With Early-Stage Rectal Cancer | N/A | terminated | Feb 6, 2008 | Vanderbilt-Ingram Cancer Center | low accrual | Enrollment / accrual |
| NCT00959946 | Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic… | Phase 1 / Phase 2 | terminated | Aug 17, 2009 | Pfizer | not stated | Not stated |
| NCT00531115 | Phase II Study to Evaluate Safety and Efficacy of Cetuximab in Combination With XELOX for… | Phase 2 | terminated | Sep 18, 2007 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) | According to the study design, in the first step the number of responses was lower than the number… | Other (stated, no rule matched) |
| NCT00681876 | Phase II Study of Avastin + Erbitux + Irinotecan as 2nd Line Treatment of Colorectal… | Phase 2 | terminated | May 21, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00755534 | Irinotecan/Cetuximab Followed by XELOX/Cetuximab vs the Reverse Sequence in Metastatic CRC | Phase 2 | terminated | Sep 19, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00002796 | Phase I-II Study of Fluorouracil in Combination With Phenylbutyrate in Advanced… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087334 | Capecitabine, Oxaliplatin, and Gefitinib in Treating Patients With Metastatic Colorectal… | Phase 1 / Phase 2 | terminated | Jul 12, 2004 | Roswell Park Cancer Institute | Withdrawn due to poor/low accrual | Enrollment / accrual |
| NCT00070122 | Combination Chemotherapy and Bevacizumab in Treating Patients With Locally Advanced,… | Phase 3 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00070265 | Neoadjuvant and Adjuvant Capecitabine and Oxaliplatin in Treating Patients With… | Phase 2 | terminated | Oct 7, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01619696 | Prospective Pilot Study of Multimodal Radiological Evaluation Feasibility During… | Phase 2 | terminated | Jun 14, 2012 | University Hospital, Toulouse | Insufficient recruitment | Enrollment / accrual |
| NCT00052585 | Gefitinib and Combination Chemotherapy in Treating Patients With Advanced or Recurrent… | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087256 | Celecoxib in Preventing Polyps in Patients Who Have Undergone Surgery for Stage I Colon… | Phase 3 | terminated | Jul 12, 2004 | NSABP Foundation Inc | For scientific, logistic, and administrative reasons. | Other (stated, no rule matched) |
| NCT00118105 | S0408: Capecitabine, Oxaliplatin, and Bevacizumab in Pts Undergoing Surgery for Liver… | Phase 2 | withdrawn | Jul 11, 2005 | SWOG Cancer Research Network | Budget Constraints | Funding |
| NCT00766220 | Yttrium Microspheres With Cetuximab Plus Irinotecan for Patients With Advanced Colorectal… | Phase 2 | withdrawn | Oct 3, 2008 | M.D. Anderson Cancer Center | Slow Accrual and withdrawn/exclusion of 2 participants. | Enrollment / accrual |
| NCT00288444 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | Phase 1 | terminated | Feb 8, 2006 | Emory University | not stated | Not stated |
| NCT00387348 | Escitalopram in Treating Depression in Patients With Advanced Lung or Gastrointestinal… | Phase 3 | terminated | Oct 13, 2006 | Massachusetts General Hospital | DSMB stopped study because placebo arm had more adverse events | Safety / toxicity |
| NCT00043004 | Chemotherapy and Bevacizumab With or Without Radiofrequency Ablation in Treating… | Phase 2 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00068744 | Radiation Therapy, Mitomycin, and Either Fluorouracil or Cisplatin in Treating Patients… | Phase 2 / Phase 3 | terminated | Sep 11, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00025532 | Radiolabeled Monoclonal Antibody Therapy in Treating Patients With Gastrointestinal Cancer | Phase 1 | withdrawn | Nov 21, 2003 | University of California, San Francisco | not stated | Not stated |
| NCT00828620 | Positron Emission Tomography - Computed Tomography (PET-CT) Cetuximab Project | — | terminated | Jan 26, 2009 | Universitaire Ziekenhuizen KU Leuven | Lack of recruitment | Enrollment / accrual |
| NCT00062023 | Comparison of Sulindac, Aspirin, and Ursodiol in Preventing Colorectal Cancer | Phase 2 | terminated | Jun 6, 2003 | M.D. Anderson Cancer Center | Study closed by the NCI. | Other (stated, no rule matched) |
| NCT00070434 | S0304 Induct Chemo Then Chemo-RT in Pts w/Locally Advanced Adenocarcinoma of the Rectum | Phase 2 | withdrawn | Oct 7, 2003 | SWOG Cancer Research Network | poor accrual | Enrollment / accrual |
| NCT01056809 | Treatment Strategies for Primarily Generalized Colorectal Cancer(PGC) | N/A | terminated | Jan 26, 2010 | Vrinnevi Hospital | Too slow recruitment | Enrollment / accrual |
| NCT01031056 | Collection of Biospecimen & Clinical Information in Patients w/ Gastrointestinal Cancers | — | withdrawn | Dec 14, 2009 | Stanford University | Change in research focus | Other (stated, no rule matched) |
| NCT00006269 | Octreotide in the Prevention of Diarrhea in Patients Receiving Irinotecan for Metastatic… | Phase 3 | terminated | May 24, 2004 | Novartis | not stated | Not stated |
| NCT00824161 | Phase II Study of TAS-109 to Treat Advanced Colorectal Cancer | Phase 2 | terminated | Jan 16, 2009 | Taiho Pharmaceutical Co., Ltd. | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Jul 24, 2013source: clinicaltrials