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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Genitourinary System Neoplasm and descendants · 88% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00995488 | Trial of Combination ABI-007, Carboplatin, and Gemcitabine for First Line Treatment of… | Phase 2 | terminated | Oct 15, 2009 | University of Michigan Rogel Cancer Center | Terminated prematurely due to low accrual. | Enrollment / accrual |
| NCT01368003 | STA-9090 in Castration-Resistant Prostate Cancer With Assessment of Androgen Receptor… | Phase 2 | withdrawn | Jun 7, 2011 | Toni Choueiri, MD | Loss of funding. | Funding |
| NCT01296035 | Panitumumab and Gemcitabine in Relapsed Ovarian Cancer(PanGem) | Phase 2 | terminated | Feb 15, 2011 | Women and Infants Hospital of Rhode Island | Newer technologies available; poor accrual to study. | Enrollment / accrual |
| NCT02109224 | Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With… | Phase 1 | terminated | Apr 9, 2014 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT01071928 | Second-Line Docetaxel + ASA404 for Advanced Urothelial Carcinoma | Phase 2 | withdrawn | Feb 19, 2010 | Hoosier Cancer Research Network | Lack of efficacy of experimental treatment | Efficacy / futility |
| NCT00471120 | Feasibility Study: Accuracy of Biomarker in Detection of Endometrial Cancer | N/A | terminated | May 9, 2007 | Dick Domanik | Study terminated due to protocol deficiencies. | Other (stated, no rule matched) |
| NCT00574483 | Treatment of Advanced Renal Cell Carcinoma With Quinacrine | Phase 2 | withdrawn | Dec 17, 2007 | Cleveland BioLabs | reevaluation of compound development | Other (stated, no rule matched) |
| NCT02022904 | Prostate Cancer Circulating Tumor Cells Based on Epithelial-Mesenchymal Transition Biology | N/A | withdrawn | Dec 30, 2013 | Duke University | not stated | Not stated |
| NCT01744821 | Vitamin D for Women at Increased Risk of Developing Ovarian, Fallopian, or Primary… | N/A | terminated | Dec 7, 2012 | Northwestern University | Inability to recruit study subjects | Enrollment / accrual |
| NCT01561482 | Study of Metformin With Simvastatin for Men With Prostate Carcinoma | Phase 2 | withdrawn | Mar 23, 2012 | Nicholas Mitsiades | Study closed due to slow/low enrollment; no subjects were enrolled. | Enrollment / accrual |
| NCT00809458 | Biomarker Study of Neoadjuvant Vitamin E in Patients With Locally Treatable Prostate… | Phase 3 | terminated | Dec 17, 2008 | New Mexico Cancer Research Alliance | Low rate of accrual. | Enrollment / accrual |
| NCT00233727 | Screen and Treat for Cervical Cancer Prevention(SAT) | Phase 3 | terminated | Oct 6, 2005 | Columbia University | PI left University | Investigator |
| NCT01808534 | Palifosfamide in Treating Patients With Recurrent Germ Cell Tumors | Phase 2 | terminated | Mar 11, 2013 | Indiana University | Due to Low Accrual | Enrollment / accrual |
| NCT01175772 | Maintenance Treatment for Ovarian Carcinoma in Remission by an Antiangiogenic Treatment… | Phase 2 | terminated | Aug 5, 2010 | HaEmek Medical Center, Israel | Due to change in the national policy of medications | Other (stated, no rule matched) |
| NCT00365443 | Broad Spectrum HPV Vaccine Tolerability, Immunogenicity, and Efficacy Study (V502-003) | Phase 2 | withdrawn | Aug 17, 2006 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00176280 | Randomized Phase 2 Trial of Pre-chemotherapy Leukine vs. Leukine-Dexamethasone in… | Phase 2 | withdrawn | Sep 15, 2005 | University of Kentucky | Slow accrual | Enrollment / accrual |
| NCT00323726 | Trends in Incidence and Survivals for Ovarian Germ Cell Tumors: A 27-Year… | — | withdrawn | May 9, 2006 | New Mexico Cancer Research Alliance | The study was limited to IRB Exempt chart review; not an applicable trial. | Other (stated, no rule matched) |
| NCT00601926 | Bevacizumab in Treating Patients With Unresectable or Metastatic Kidney Cancer | Phase 2 | terminated | Jan 28, 2008 | Paul Monk | Poor patient accrual. Attempts to open at other sites unsuccessful. | Enrollment / accrual |
| NCT01314664 | A Prospective Registry to Assess the Effectiveness and Local Tolerability of Intravesical… | — | terminated | Mar 14, 2011 | Endo USA Inc., a Keenova Therapeutics Company | Business decision, not safety related | Safety / toxicity |
| NCT00581113 | Neural Stem Cell Preserving Brain Radiation Therapy & Stereotactic Radiosurgery in… | Phase 3 | terminated | Dec 27, 2007 | Virginia Commonwealth University | New research priorities | Other (stated, no rule matched) |
| NCT01705652 | Study to Assess the Activity of Nexrutine® in Prostate Cancer Patients(Nexrutine) | Phase 2 | terminated | Oct 12, 2012 | The University of Texas Health Science Center at San Antonio | loss of funding | Funding |
| NCT01880996 | Tai-chi / Qi-gong in Patients With Patients With Gynecological Malignancies | Phase 1 / Phase 2 | withdrawn | Jun 19, 2013 | Sheba Medical Center | The deparment failed to detect patients that were willing to participate in this study | Other (stated, no rule matched) |
| NCT00589550 | PEG-Interferon Alfa-2b and Sorafenib in Treating Patients With Unresectable or Metastatic… | Phase 1 | terminated | Jan 9, 2008 | Thomas Olencki | low accrual | Enrollment / accrual |
| NCT00921258 | Active Control of Prostatic Cancer With Criteria of Latence(SURACAP) | — | terminated | Jun 16, 2009 | Clinique Mutualiste Chirurgicale de la Loire | Financial problem (not enough budget to continue the study) | Funding |
| NCT01242748 | A Degarelix Trial in Patients With Prostate Cancer | Phase 3 | terminated | Nov 17, 2010 | Ferring Pharmaceuticals | Inadequate recruitment resulting in a too low patient number for collection of long term efficacy… | Efficacy / futility |
| NCT01374789 | PURO Panitumumab in Combination With Gemcitabine/Cisplatin in Advanced Urothelial Cancer(PURO) | Phase 2 | terminated | Jun 16, 2011 | WiSP Wissenschaftlicher Service Pharma GmbH | The study was terminated due to insufficient recruitment. | Enrollment / accrual |
| NCT01520441 | BOTOX in Men With Prostate Cancer With Lower Urinary Tract Symptoms(LUTS)/Benign… | Early Phase 1 | withdrawn | Jan 30, 2012 | The University of Texas Health Science Center, Houston | not stated | Not stated |
| NCT02424513 | A Study of Positron Emission Tomography (PET) With [89]Zr-Df-IAb2M in Patients With… | Phase 2 | withdrawn | Apr 23, 2015 | ImaginAb, Inc. | Clinical trial was postponed as a result of restructured business priorities. | Sponsor / business decision |
| NCT00053235 | Research Study in Patients With Advanced Ovarian Epithelial Cancer | — | withdrawn | Jan 28, 2003 | Gynecologic Oncology Group | not stated | Not stated |
| NCT00118066 | Calcitriol in Preventing Prostate Cancer in Patients With Prostatic Intraepithelial… | Phase 2 | terminated | Jul 11, 2005 | Rutgers, The State University of New Jersey | Slow accruaL, lack of scientific progress | Enrollment / accrual |
| NCT00824928 | Salvage Cryotherapy in Recurrent Prostate Cancer(SCORE) | — | terminated | Jan 19, 2009 | University of Colorado, Denver | Study was ended due to low enrollment | Enrollment / accrual |
| NCT01200797 | SJG-136 in Treating Patients With Epithelial Ovarian, Primary Peritoneal, or Fallopian… | Phase 2 | terminated | Sep 14, 2010 | National Cancer Institute (NCI) | Slow accrual was the reason for study termination. | Enrollment / accrual |
| NCT01198535 | Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer | Phase 1 | terminated | Sep 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01401829 | Psychosocial Benefits of Exercise in Endometrial Cancer Survivors | Phase 1 | terminated | Jul 25, 2011 | University of Alabama at Birmingham | Terminated due to lack of funding required to continue the study. | Funding |
| NCT01769911 | Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With… | N/A | withdrawn | Jan 17, 2013 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT02235324 | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in… | Phase 2 | withdrawn | Sep 9, 2014 | University of Southern California | Lack of funding | Funding |
| NCT01507740 | Profile of Soluble and Cellular Biomarkers and of Functional Imaging During… | — | terminated | Jan 11, 2012 | Medical University Innsbruck | Study was stopped 04.10.2014 prematurly after recruitment of HCC and RCC patients. NSCLC (2 of 10… | Enrollment / accrual |
| NCT00785694 | Recurrence of Bladder Cancer After Transurethral Resection With Hexvix | Phase 4 | withdrawn | Nov 5, 2008 | GE Healthcare | Rejected ethics approval in UK and Holland | Other (stated, no rule matched) |
| NCT00176293 | Randomized Phase II Trial of Doxil With or Without Dexamethasone for Metastatic Hormone… | Phase 2 | terminated | Sep 15, 2005 | University of Kentucky | Slow accrual | Enrollment / accrual |
| NCT02420587 | AMG 208 Tumor Microenvironment in Metastatic Castration Resistant Prostate Cancer (mCRPC) | Phase 2 | withdrawn | Apr 20, 2015 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00003880 | Paclitaxel Plus Carboplatin With or Without SCH-58500 in Treating Patients With Newly… | Phase 2 / Phase 3 | terminated | Apr 23, 2004 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00217464 | Fulvestrant in Treating Patients With Recurrent Prostate Cancer | Phase 2 | terminated | Sep 22, 2005 | Roswell Park Cancer Institute | Closed for futility | Efficacy / futility |
| NCT02095847 | High-Resolution Microendoscopy to Guide Hysteroscopic Tumor Resection | Phase 2 | withdrawn | Mar 26, 2014 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01274572 | Blood for Immune Response to Provenge® in HRPC | — | withdrawn | Jan 11, 2011 | Mary Crowley Medical Research Center | Drug became available with insurance reimbursement | Other (stated, no rule matched) |
| NCT01226290 | Fibroid Ablation Study(FAST-EU) | N/A | terminated | Oct 22, 2010 | Gynesonics | Investigational device changes; adequate enrollment achieved | Enrollment / accrual |
| NCT00930345 | Biological, Pathological and Imagery Markers in the First-line Treatment of Metastatic…(PREINSUT) | Phase 4 | terminated | Jun 30, 2009 | Assistance Publique - Hôpitaux de Paris | not stated | Not stated |
| NCT01267266 | Saracatinib in Treating Patients With Prostate Cancer | Phase 2 | terminated | Dec 28, 2010 | National Cancer Institute (NCI) | Per protocol, study was terminated due to low rate of randomized patients. | Other (stated, no rule matched) |
| NCT01732432 | Endometriosis and Frequency of Endometriosis-associated Ovarian Carcinomas (EAOC)(EAOC) | — | withdrawn | Nov 22, 2012 | University Hospital, Basel, Switzerland | not stated | Not stated |
| NCT01547676 | Clamped or Unclamped Surgery in Treating Patients With Kidney Cancer | N/A | terminated | Mar 8, 2012 | University of Southern California | P.I. decided to terminate study due to multiple unresolved issues | Other (stated, no rule matched) |
| NCT00736216 | Knowledge and Perceptions About Human Papillomavirus and Cervical Cancer Risk Among Young… | — | withdrawn | Aug 15, 2008 | Case Comprehensive Cancer Center | PI left the institution | Investigator |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Sep 11, 2015source: clinicaltrials